As Filed with the Securities and Exchange Commission on August 23, 2002.
                                                      Registration No. 333-96739


                       Securities and Exchange Commission
                             Washington, D.C. 20549

                          Pre-Effective Amendment No. 1
                                       to
                                    Form S-3

                             Registration Statement
                                      Under
                           The Securities Act of 1933


                              Antares Pharma, Inc.
             (Exact Name of Registrant as Specified in its Charter)

                      Minnesota                         41-1350192
             (State or Other Jurisdiction           (I.R.S. Employer
           of Incorporation or Organization)     Identification Number)


                             707 Eagleview Boulevard
                                    Suite 414
                                 Exton, PA 19341
                                 (610) 458-6200
   (Address, Including Zip Code, and Telephone Number, Including Area Code, of
                    Registrant's Principal Executive Offices)


                            Roger G. Harrison, Ph.D.
                             Chief Executive Officer
                              Antares Pharma, Inc.
                             707 Eagleview Boulevard
                                    Suite 414
                                 Exton, PA 19341
                                 (610) 458-6200
 (Name, Address, Including Zip Code, and Telephone Number, Including Area Code,
                              of Agent for Service)

APPROXIMATE DATE OF COMMENCEMENT OF PROPOSED SALE TO THE PUBLIC: From time to
time after this registration statement becomes effective.

If the only securities being registered on this Form are being offered pursuant
to dividend or interest reinvestment plans, please check the following box. [_]

If any of the securities being registered on this Form are to be offered on a
delayed or continuous basis pursuant to Rule 415 under the Securities Act of
1933, other than securities offered only in connection with dividend or interest
reinvestment plans, check the following box. [X]

If this Form is filed to register additional securities for an offering pursuant
to Rule 462(b) under the Securities Act, please check the following box and list
the Securities Act registration statement number of the earlier effective
registration statement for the same offering. [_]__________

If this Form is a post-effective amendment filed pursuant to Rule 462(c) under
the Securities Act, check the following box and list the Securities Act
registration statement number of the earlier effective registration statement
for the same offering. [_]__________

If delivery of the prospectus is expected to be made pursuant to Rule 434,
please check the following box. [_]


The Registrant hereby amends this Registration Statement on such date or dates
as may be necessary to delay its effective date until the Registrant files a
further amendment which specifically states that this Registration Statement
shall thereafter become effective in accordance with Section 8(a) of the
Securities Act of 1933, as amended, or until this Registration Statement shall
become effective on such date as the Securities and Exchange Commission, acting
pursuant to such Section 8(a), may determine.

================================================================================



********************************************************************************
The information in this prospectus is not complete and may be changed. The
selling securityholders may not sell these securities until the registration
statement filed with the Securities and Exchange Commission is effective.
This prospective is not an offer to sell these securities and it is not
soliciting an offer to buy these securities in any state where the offer or sale
is not permitted.
********************************************************************************

                  SUBJECT TO COMPLETION, DATED AUGUST 23, 2002

                             PRELIMINARY PROSPECTUS

                               1,600,000 SHARES OF

                              ANTARES PHARMA, INC.

                                  COMMON STOCK


     This prospectus relates to the offering of 1,600,000 shares of our common
stock which may be sold from time to time by the selling shareholders named in
this prospectus. These shares of common stock are issuable to the selling
shareholders upon conversion of secured convertible debentures. The debentures
are convertible at a per share price which is the lower of $2.50 or 75% of the
average of the three lowest intraday trading prices of our common stock, as
reported on the Nasdaq SmallCap Market, during the 20 trading days prior to the
conversion date.

     The shares of our common stock are being registered to permit the selling
shareholders to sell the shares from time to time in the public market. The
shareholders may sell the shares in negotiated transactions or otherwise, at
market prices prevailing at the time of sale or at negotiated prices. The timing
and amount of any sale are within the sole discretion of the selling
shareholders. In addition, the shares may be offered from time to time through
ordinary brokerage transactions, directly to market makers of our shares or
through any other means described in the section entitled "Plan of Distribution"
beginning on page 18.

     We will not receive any of the proceeds from the sale of the shares
although we have paid the expenses of preparing this prospectus and the related
registration expenses.

     Our common stock is quoted on the Nasdaq SmallCap Market under the symbol
"ANTR." The last reported sales price of our common stock on the Nasdaq SmallCap
Market on August 21, 2002 was $1.96 per share. The three lowest intraday
trading prices of our common stock during the 20 trading days ending on August
21, 2002 were $1.76, $2.00 and $2.11.


BEFORE PURCHASING ANY OF THE SHARES COVERED BY THIS PROSPECTUS, YOU SHOULD
CAREFULLY READ AND CONSIDER THE RISK FACTORS AND UNCERTAINTIES DISCUSSED IN THE
SECTION ENTITLED "RISK FACTORS" BEGINNING ON PAGE 3. YOU SHOULD BE PREPARED TO
ACCEPT ANY AND ALL OF THE RISKS ASSOCIATED WITH PURCHASING THE SHARES, INCLUDING
A LOSS OF YOUR INVESTMENT.

                            -------------------------

NEITHER THE SECURITIES AND EXCHANGE COMMISSION NOR ANY STATE SECURITIES
REGULATORS HAS APPROVED OR DISAPPROVED OF THESE SECURITIES OR DETERMINED IF THIS
PROSPECTUS IS TRUTHFUL OR COMPLETE. ANY REPRESENTATION TO THE CONTRARY IS A
CRIMINAL OFFENSE.


                 The date of this prospectus is ________, 2002.



                                TABLE OF CONTENTS

Forward Looking Statements ..............................................   i

Incorporation by Reference ..............................................   i

Recent Developments Regarding Issuance of Securities ....................  ii

Summary .................................................................   1

Risk Factors ............................................................   3

Use of Proceeds .........................................................  15

Selling Shareholders ....................................................  16

Certain Information About the Selling Shareholders ......................  17

Plan of Distribution ....................................................  18

Legal Matters ...........................................................  20

Experts .................................................................  20

Indemnification .........................................................  21

Where You Can Find More Information .....................................  21




                           FORWARD LOOKING STATEMENTS

     This prospectus and the documents incorporated by reference herein contain
forward-looking statements within the meaning of the securities laws. These
forward-looking statements are subject to a number of risks and uncertainties,
many of which are beyond our control. All statements other than statements of
historical facts included or incorporated by reference in this prospectus
regarding our strategy, future operations, financial position, estimated
revenues, projected costs, prospects, plans and objectives of management are
forward-looking statements. When used in this prospectus, the words "will,"
"believe," "anticipate," "intend," "estimate," "expect," "project" and similar
expressions are intended to identify forward-looking statements, although not
all forward-looking statements contain such identifying words. All
forward-looking statements speak only as of the date of this prospectus. Neither
we nor the selling shareholders undertake any obligation to update or revise
publicly any forward-looking statements, whether as a result of new information,
future events or otherwise. Although we believe that our plans, intentions and
expectations reflected in or suggested by the forward-looking statements that we
make in this prospectus are reasonable, we can give no assurance that such
plans, intentions or expectations will be achieved. The cautionary statements
qualify all forward-looking statements attributable to us or persons acting on
our behalf.


                           INCORPORATION BY REFERENCE

     The SEC allows us to "incorporate by reference" the information we file
with them, which means that we can disclose important information to you by
referring you to those documents. The information incorporated by reference is
an important part of this prospectus, and information that we file later with
the SEC will automatically update and supersede this information. We incorporate
by reference into this prospectus and refer you to the documents listed below:

     o    our Annual Report on Form 10-K for the fiscal year ended December 31,
          2001, filed with the SEC on April 15, 2002;
     o    our Quarterly Report on Form 10-Q for the quarter ended March 31,
          2002, filed with the SEC on May 13, 2002;
     o    our Current Report on Form 8-K filed with the SEC on June 28, 2002,
          announcing the conversion of $2 million principal amount of debt plus
          accrued interest payable to Jacques Gonella into 509,137 shares of
          common stock;
     o    our Current Report on Form 8-K filed with the SEC on July 17, 2002,
          announcing the completion of the sale of our 10% convertible
          debentures;
     o    our Quarterly Report on Form 10-Q for the quarter ended June 30, 2002,
          filed with the SEC on August 14, 2002;
     o    the description of our common stock contained in our registration
          statement on Form S-1/A, filed on August 15, 1996, including any
          amendment or report filed for the purpose of updating the description;
          and
     o    any future filings we will make with the SEC under Sections 13(a),
          13(c), 14 or 15(d) of the Exchange Act after the date of this
          registration statement and prior to the filing of a post-effective
          amendment that indicates that all shares offered have been sold or
          which deregisters all shares then remaining unsold.

     This prospectus is part of a registration statement on Form S-3 filed with
the SEC under the Securities Act. This prospectus does not contain all of the
information set forth in the registration statement. You should read the
registration statement for further information about our company and the common
stock.

                                       i



You may request, orally or in writing, a copy of these filings. We will provide
the copies of these filings to you at no cost. Please direct your requests to:

                              Antares Pharma, Inc.
                             707 Eagleview Boulevard
                                    Suite 414
                            Exton, Pennsylvania 19341
                            Attn: Lawrence Christian
                                 (610) 458-6200

You may also find information about us at our website:
http://www.antarespharma.com. You should rely only on the information
incorporated by reference or provided in this prospectus or any prospectus
supplement. We have not authorized anyone else to provide you with different
information. You should not assume that the information in this prospectus or
any prospectus supplement is accurate as of any date other than the date on the
front page of those documents.


              RECENT DEVELOPMENTS REGARDING ISSUANCE OF SECURITIES

     Because our common stock is listed on the Nasdaq SmallCap Market, we are
subject to the NASD Nasdaq Marketplace Rules. Rule 4350(i)(1)(D) requires that
we obtain shareholder approval for any issuance of our common stock at a price
below the market price where the amount of stock being issued exceeds 20% or
more of the common stock or 20% or more of the voting power outstanding before
the issuance. This registration statement is being filed to register the shares
of common stock issuable upon conversion of convertible debentures we recently
sold in a private placement. We held a special meeting of our shareholders on
August 23, 2002. At the special meeting, we received shareholder approval to
issue common stock in excess of 19.99% of our currently outstanding shares of
common stock upon conversion of the debentures.

                                       ii



                                     SUMMARY

Introduction

     The following summary does not contain all of the information that may be
important to you. You should read the entire prospectus, including the financial
statements and other information incorporated by reference in this prospectus,
before making an investment decision.

     The terms "company," "Antares," "registrant," "we," "us," and "our" in this
prospectus refer to Antares Pharma, Inc.

The Company and our Business

     We were incorporated in Minnesota on January 31, 1979 under the name Derata
Corporation. We changed our name to Medi-Ject Corporation on November 16, 1992.
On January 31, 2001, we completed a business combination to acquire the three
operating subsidiaries of Permatec Holding AG, headquartered in Basel,
Switzerland. Prior to the closing of the business combination, we did not have
sufficient funds to continue our operations, and we had determined that it was
necessary to, among other things, either raise more capital or merge with
another biopharmaceutical company. Medi-Ject was a company focused on delivery
of drugs across the skin using needle free technology, and Permatec specialized
in delivery of drugs across the skin using transdermal patch and gel
technologies. Given that both groups were focused on delivery of drugs across
the skin, but with a focus on different sectors, we believed that a business
combination would be attractive to both pharmaceutical partners and to our
shareholders.

     The business combination transaction with the Permatec subsidiaries was
accounted for as a reverse merger because upon the closing of the transaction,
Permatec owned in excess of 67% of the outstanding shares of our common stock.
The historical financial statements of Permatec thus became those of the
company. Upon consummation of the transaction, the acquired Permatec
subsidiaries were renamed Antares Pharma AG, Antares Pharma IPL AG and Antares
Pharma NV, and we changed our name to Antares Pharma, Inc. The following
discussion of our business includes our operations following the transaction
with Permatec.

     We develop, manufacture and market medical devices, called jet injectors,
that allow people to self-inject drugs without using a needle. These jet
injectors utilize a small spring-action device and attached disposable plastic
syringes to hold the drug. A liquid drug is drawn up into the syringe through a
small hole at the end. When the syringe is held against the body and the spring
is released, a piston drives the fluid stream into the tissues beneath the skin.
A person may re-arm the device and repeat the process or attach a new sterile
syringe between injections. Recently we have developed a variation of our jet
injector by adding a very small hidden needle to a pre-filled, single-use
injector.

     With the Permatec combination, we are also committed to other methods of
drug delivery, including trandsdermal patches and topical gel formulations. We
intend for these other drug delivery methods to become a material part of our
business moving forward.

     We plan to operate in the specialized drug delivery sector of the
pharmaceutical industry. Companies in this sector generally bring technology and
know-how in the area of drug formulation (in our case, injection devices) to
pharmaceutical manufacturers through licensing and development agreements. Our
principal customer is the pharmaceutical manufacturer. We have negotiated and
executed licensing relationships in the growth hormone segment (needle-free
devices in Europe and Asia), the hormone replacement segment (transdermal
delivery of estradiol in South America) and topical


                                       1



hormone gels segment (several development programs in place worldwide). In
addition, we continue to market needle-free devices for the home administration
of insulin in the U.S. and international markets as we seek a distribution
relationship with an insulin manufacturer.

     Our principal executive office is located at 707 Eagleview Boulevard, Suite
414, Exton, Pennsylvania 19341, and our telephone number at that office is (610)
458-6200. We have wholly-owned subsidiaries in Switzerland (Antares Pharma AG
and Antares Pharma IPL AG) and the Netherlands Antilles (Antares Pharma NV). Our
United States research and manufacturing facility is located in Minneapolis,
Minnesota.


                                       2



                                  RISK FACTORS

     You should consider carefully the following information about risks,
together with the other information contained in this prospectus and in the
documents referred to below in "Where You Can Find More Information," before you
decide whether to buy our common stock. Additional risks and uncertainties not
known to us or that we now believe to be unimportant could also impair our
business. If any of the following risks actually occur, our business, results of
operations and financial condition could suffer significantly. As a result, the
market price of our common stock could decline and you could lose all of your
investment.

                          Risks Related to Our Business

We will require additional capital to continue operations beyond approximately
October 2002

     Following our receipt of a $2 million loan from our majority shareholder,
Jacques Gonella (which was converted into shares of our common stock on June 20,
2002), and our receipt of the proceeds of the sale of an aggregate of $2 million
of our 10% convertible debentures, of which we have received $1,400,000 to date,
our cash position will be insufficient to fund working capital requirements
beyond approximately October 2002 and will not be sufficient for us to reach
profitability. We expect our working capital needs over the next twelve months
to approximate $10.0 million. This amount consists of approximately $7.0 million
for research and development, $500,000 for business development, $1.2 million
for marketing and sales, $600,000 for regulatory and quality assurance and $5.7
million for general and administrative expenses, all of which is offset by
approximately $5.1 million of projected license fees and net product margins. We
are currently seeking funds through additional equity or debt offerings, equity
investments by our strategic partners/customers and divestment of non-core
technologies. There can be no assurance that sufficient additional equity or
debt financing will be available. If we cannot obtain financing when needed, or
obtain it on favorable terms, we may be required to curtail development of new
drug technologies or expansion of manufacturing capacity or cease operations
altogether.

We have incurred significant losses to date, and for our last fiscal year we
received an opinion from our accountants expressing doubt on our ability to
continue as a going concern

     The report of our independent accountants in our 10-K for the fiscal year
ended December 31, 2001, contains an explanatory paragraph expressing
substantial doubt about our ability to continue as a going concern as a result
of recurring losses and negative cash flows from operations. We had negative
working capital of ($2,439,577), ($11,712) and ($2,016,280) at December 31, 2000
and 2001, and June 30, 2002, respectively. We incurred net losses of
($3,967,366), ($5,260,387), ($9,499,101) and ($4,113,524) in 1999, 2000 and
2001, and in the six months ended June 30, 2002, respectively. In addition, we
have accumulated aggregate net losses from the inception of business through
June 30, 2002, of approximately $33,570,557.

     The costs for research and product development of our drug delivery
technologies along with marketing and selling expenses and general and
administrative expenses have been the principal causes of our losses. We expect
to report a net loss for the year ending December 31, 2002, as marketing and
development costs related to bringing future generations of products to market
continue. Long-term capital requirements will depend on numerous factors,
including the status of collaborative arrangements, the progress of research and
development programs and the receipt of revenues from sales of products. Our
ability to achieve and/or sustain profitable operations depends on a number of
factors, many of which are beyond our control. These factors include the
following:


                                       3



     o    the demand for our technologies;
     o    our ability to manufacture products efficiently and with the required
          quality;
     o    our ability to increase manufacturing capacity;
     o    the level of product and price competition;
     o    our ability to develop additional commercial applications for our
          products;
     o    our ability to obtain regulatory approvals;
     o    our ability to control costs; and
     o    general economic conditions.

We depend on a limited number of customers for the majority of our revenue, and
the loss of any one of these customers could substantially reduce our revenue


     During the first seven months of 2002, we derived 86% of our revenue from
the following three customers:

     o    Ferring Pharmaceutical NV (57%)
     o    BioSante Pharmaceuticals, Inc. (25%)
     o    Solvay Pharmaceuticals B.V. (4%)

     The loss of any one of these customers could cause revenues to decrease
significantly, resulting in, or increasing, our losses from operations. If we
cannot broaden our customer base, we will continue to depend on a few customers
for the majority of our revenues. We may be unable to negotiate favorable
business terms with customers that represent a significant portion of our
revenues. If that occurs, our revenues and gross profits may be insufficient to
allow us to achieve and/or sustain profitability.

We have limited manufacturing experience and may experience manufacturing
difficulties related to the use of new materials and procedures, which could
increase our production costs and, ultimately, decrease our profits

     Our past assembly, testing and manufacturing experience for certain of our
technologies has involved the assembly of products from machined stainless steel
and composite components in limited quantities. Our planned future drug delivery
technologies necessitate significant changes and additions to our manufacturing
and assembly process to accommodate new components. These systems must be
manufactured in compliance with regulatory requirements, in a timely manner and
in sufficient quantities while maintaining quality and acceptable manufacturing
costs. In addition, our plans call for significantly increased levels of
production and a shift to performing more manufacturing functions internally
rather than relying on third-party suppliers, which will require us to
eventually expand beyond our current facilities. In the course of these changes
and additions to our manufacturing and production methods, we may encounter
difficulties, including problems involving yields, quality control and
assurance, product reliability, manufacturing costs, existing and new equipment,
component supplies and shortages of personnel, any of which could result in
significant delays in production. There can be no assurance that we will be able
to successfully produce and manufacture our drug delivery technology. Any
failure to do so would negatively impact our business, financial condition and
results of operations.

Our technologies have achieved only limited acceptance by patients and
physicians, which could have a negative effect on our revenue

     Our revenues depend on ultimate patient and physician acceptance of our
needle-free injectors, gels, patches and our other potential drug delivery
technologies as an alternative to more traditional forms


                                       4




of drug delivery including injections using a needle, tablets and liquid
formulas. To date, these delivery technologies have achieved only limited
acceptance from such parties. If our drug delivery technologies are not accepted
in the marketplace, the pharmaceutical company partners may be unable to
successfully market and sell our products, which would limit our ability to
generate revenues and to achieve and/or sustain profitability. The degree of
acceptance of our drug delivery systems depends on a number of factors. These
factors include the following:

     o    demonstrated clinical efficacy and safety;
     o    cost-effectiveness;
     o    convenience and ease of administration of injectors, transdermal gels
          and patches;
     o    advantages over alternative drug delivery systems; and
     o    marketing and distribution support.

     Physicians may refuse to prescribe products incorporating our drug delivery
technologies if the physicians believe that the active ingredient is better
administered to a patient using alternative drug delivery technologies or the
physicians believe that the delivery method will result in patient
noncompliance. Factors such as allergic reactions, patient perceptions that a
gel is inconvenient and cosmetic considerations about patches may cause patients
to reject our drug delivery technologies.

     In addition, we expect that the pharmaceutical company partners will price
products incorporating their drug delivery technologies slightly higher than
conventional methods, which may impair their acceptance. Because only a limited
number of products incorporating our drug delivery technologies are commercially
available, we cannot yet assess the level of market acceptance of our drug
delivery technologies.

Our success depends on the market acceptance of alternative drug delivery
technologies, and the failure to obtain such acceptance could substantially
reduce our revenue

     Our success will, in large part, depend upon increasing market acceptance
of our drug delivery technologies as an alternative to traditional delivery
systems. During the time period since initial commercial introduction, our
products have had only limited success competing with traditional drug delivery
systems for a variety of reasons, including the size, cost and complexity of use
and maintenance of our drug delivery technologies and the relatively small
number of drugs that have been self-administered. In order to increase market
acceptance, we believe that we must successfully develop improvements in the
design and functionality of future drug delivery technology that will reduce
cost and increase appeal to users, thereby making these technologies desirable
despite their premium cost over traditional drug delivery systems. Projected
improvements in functionality and design may not adequately address the actual
or perceived complexity of using our drug delivery technologies or adequately
reduce cost. In addition, we believe that our future success depends upon our
ability to enter into additional collaborative agreements with drug and medical
device manufacturers, as discussed below. There can be no assurance that we will
be successful in these efforts or that our drug delivery technologies will ever
gain sufficient market acceptance to achieve and/or sustain profitable
operations.

     Although transdermal patches are a well-accepted method of drug delivery,
many other companies compete in this sector. Because the cost of manufacturing
equipment for transdermal patches is high, most manufacturing is done by a
limited number of contract manufacturers. Therefore, our costs will remain high
and our pricing options will be limited. We may develop a superior patch, but we
may not be able to price it competitively, or our margins may not justify
maintaining the business if our market share is low. Patches are not central to
our business strategy and may suffer from lack of attention. There can be no
assurance that we will be successful in the transdermal patch market.


                                       5



     Because transdermal gels are a newer, less understood method of drug
delivery, our potential consumers, the pharmaceutical manufacturers, have little
experience with manufacturing costs or pricing parameters. Our assumption of
higher value may not be shared by the consumer. To date, transdermal gels have
gained successful entry into only a limited number of markets. There can be no
assurance that transdermal gels will ever gain sufficient market acceptance in
those or other markets to achieve and/or sustain profitable operations.

     Although the injectable gel research field is active, there is essentially
no data regarding consumer acceptance. Regulatory compliance and approvals can
take a substantial amount of time due to clinical evaluations that are required
for this type of method but not for other drug delivery methods. There can be no
assurance that injectable gels will ever obtain the necessary regulatory
approvals or gain sufficient market acceptance to achieve and/or sustain
profitable operations.

A recent FDA study questioned the safety of hormone replacement therapy for
menopausal women, and our female hormone replacement therapy business may suffer
as a result

     In July 2002, the Federal Drug Administration halted a study being
conducted on oral female hormone replacement therapy (HRT) because the study
showed an increased risk of breast cancer, heart disease and blood clots in
women taking HRT. The study looked at only one brand of oral HRT, and there is
no information on whether other brands with different levels of hormones would
carry the same risks. Because the FDA's findings are very recent, we cannot
assess what impact, if any, they will have on the HRT market as a whole, or on
our own HRT product line. Additionally, there is no information at this point
regarding whether the transdermal gels and patches that we market for HRT will
be shown to carry the same risks as those found in the study.

We rely on third parties to supply components for our products, and any failure
to retain relationships with these third parties could negatively impact our
ability to manufacture our products

     Certain of our technologies contain a number of customized components
manufactured by various third parties. Regulatory requirements applicable to
medical device and transdermal patch manufacturing can make substitution of
suppliers costly and time-consuming. In the event that we could not obtain
adequate quantities of these customized components from our suppliers, there can
be no assurance that we would be able to access alternative sources of such
components within a reasonable period of time, on acceptable terms or at all.
The unavailability of adequate quantities, the inability to develop alternative
sources, a reduction or interruption in supply or a significant increase in the
price of components could have a material adverse effect on our ability to
manufacture and market our products.

We may be unable to successfully expand into new areas of drug delivery
technology, which could substantially reduce our revenue and negatively impact
our business as a whole

     We intend to continue to enhance our current technologies and pursue
additional proprietary drug delivery technologies. Even if enhanced or
additional technologies appear promising during various stages of development,
we may not be able to develop commercial applications for them because

     o    the potential technologies may fail clinical studies;
     o    we may not find a pharmaceutical company to adopt the technologies;
     o    it may be difficult to apply the technologies on a commercial scale;
     o    the technologies may be uneconomical to market; or
     o    we may not receive necessary regulatory approvals for the potential
          technologies.


                                       6




We have not yet completed research and development work or obtained regulatory
approval for any technologies for use with any drugs other than insulin, human
growth hormone and estradiol. There can be no assurance that any newly developed
technologies will ultimately be successful or that unforeseen difficulties will
not occur in research and development, clinical testing, regulatory submissions
and approval, product manufacturing and commercial scale up, marketing, or
product distribution related to any such improved technologies or new uses. Any
such occurrence could materially delay the commercialization of such improved
technologies or new uses or prevent their market introduction entirely.



As health insurance companies and other third-party payors increasingly
challenge the products and services for which they will provide coverage, our
individual consumers may be unable to afford to use our products, which could
substantially reduce our revenues

     Our injector device products are currently sold in the European Community
(EC) and in the United States for use with human growth hormone or insulin. In
the United States the injector products are only available for use with insulin.
A transdermal patch containing estradiol for hormone replacement therapy is sold
in Chile. Although it is impossible for us to identify the amount of sales of
our products that our customers will submit for payment to third-party insurers,
at least some of these sales may be dependent in part on the availability of
adequate reimbursement from these third-party healthcare payors. Currently,
insurance companies and other third-party payors reimburse the cost of certain
technologies on a case-by-case basis and may refuse reimbursement if they do not
perceive benefits to the technologies' use in a particular case. Third-party
payors are increasingly challenging the pricing of medical products and
services, and there can be no assurance that such third-party payors will not in
the future increasingly reject claims for coverage of the cost of certain of our
technologies. Insurance and third party payor practice vary from country to
country, and changes in practices could negatively affect our business if the
cost burden for our technologies were shifted more to the patient. Therefore,
there can be no assurance that adequate levels of reimbursement will be
available to enable us to achieve or maintain market acceptance of our
technologies or maintain price levels sufficient to realize profitable
operations. There is also a possibility of increased government control or
influence over a broad range of healthcare expenditures in the future. Any such
trend could negatively impact the market for our drug delivery technologies.


The loss of any existing licensing agreements or the failure to enter into new
licensing agreements could substantially affect our revenue

     We believe that the introduction and broad acceptance of our drug delivery
technologies is in part dependent upon the success of our current and any future
development and licensing arrangements with pharmaceutical and medical device
companies covering the development, manufacture, use and marketing of drug
delivery technologies with specific parenteral drug therapies. We anticipate
that under these arrangements the pharmaceutical or medical device company will
assist in the development of systems for such drug therapies and collect or
sponsor the collection of the appropriate data for submission for regulatory
approval of the use of the drug delivery technology with the licensed drug
therapy. The pharmaceutical or medical device company also will be responsible
for distribution and marketing of the technologies for these drug therapies
either worldwide or in specific territories. We are currently a party to a
number of such agreements. There can be no assurance that we will be successful
in executing additional agreements with pharmaceutical or medical device
companies or that existing or future agreements will result in increased sales
of our drug delivery technologies. If we do not enter into additional agreements
in the future, or if our current or future agreements do not result in
successful marketing of our products, our business, results of operations and
financial condition could be adversely affected, and our revenues and gross
profits may be insufficient to allow us to achieve and/or sustain profitability.
As a result of these arrangements, we are dependent upon the development, data
collection and marketing efforts of such pharmaceutical and medical device
companies. The amount and timing of


                                       7




resources such pharmaceutical and medical device companies devote to these
efforts are not within our control, and such pharmaceutical and medical device
companies could make material decisions regarding these efforts that could
adversely affect our future financial condition and results of operations. In
addition, factors that adversely impact the introduction and level of sales of
any drug covered by such licensing arrangements, including competition within
the pharmaceutical and medical device industries, the timing of regulatory or
other approvals and intellectual property litigation, may also negatively affect
sales of our drug delivery technology.

     Additional risks that we face related to our collaborative agreements
include the following:

     o    other pharmaceutical and biotechnology companies may not consider our
          technology the most appropriate to provide the additional benefit such
          companies require in order for them to justify investment in our
          technology, and as a result we may be unable to enter into
          collaborative agreements to develop additional products using drug
          delivery technologies;
     o    any existing or future collaborative agreements may not result in
          additional commercial products;
     o    additional commercial products that we may develop may not be
          successful;
     o    although none of our collaborative agreements have been terminated for
          failure to meet milestones, we may not be able to meet future
          milestones established in our agreements (such milestones generally
          being structured around satisfactory completion of certain phases of
          clinical development, regulatory approvals and commercialization of
          our product) and thus, would not receive the fees; and
     o    we may not be able to develop successful new drug delivery
          technologies that will be attractive to potential pharmaceutical
          company partners.

The failure of any of our third party licensees to develop, obtain regulatory
approvals for, market, distribute and sell our products could substantially
reduce our revenue

     Pharmaceutical company partners help us develop, obtain regulatory
approvals for, manufacture and sell our products. If one or more of these
pharmaceutical company partners fail to pursue the development or marketing of
the products as planned, our revenues and gross profits may not reach
expectations or may decline. We may not be able to control the timing and other
aspects of the development of products because pharmaceutical company partners
may have priorities that differ from ours. Therefore, commercialization of
products under development may be delayed unexpectedly. Further, we may
incorporate certain of our drug delivery technologies into the oral dosage forms
of products marketed and sold by pharmaceutical company partners. We do not have
a direct marketing channel to consumers for drug delivery technologies.
Therefore, the success of the marketing organizations of the pharmaceutical
company partners, as well as the level of priority assigned to the marketing of
the products by these entities, which may differ from our priorities, will
determine the success of the products incorporating our technologies.

Because the barriers to entry in our product market are low, we face increasing
competition which could force us to reduce our prices and, consequently,
decrease our planned profits

     Our current competition comes primarily from traditional hypodermic needles
and syringes that are used for the vast majority of injections administered
today and from transdermal patch and gel products marketed by others. Currently,
competition in the needle-free injection market is limited to small companies
with limited financial and other resources, but the barriers to entry are
currently low, and additional competitors may enter the needle-free injection
systems market, including companies with substantially greater resources and
experience than us. There can be no assurance that we will be able to


                                       8



compete effectively against our current or potential competitors in the drug
delivery market, or that such competitors will not succeed in developing or
marketing products that will be more accepted in such market. Competition in
this market could also force us to reduce the prices of our technologies below
currently planned levels, which could adversely affect our revenues and future
profitability.


We have applied for, and have received, several patents, and we may be unable to
protect our intellectual property, which would negatively affect our ability to
compete

     Our success depends, in part, on our ability to obtain and enforce patents
for our products, processes and technologies and to preserve our trade secrets
and other proprietary information. If we cannot do so, our competitors may
exploit our innovations and deprive us of the ability to realize revenues and
profits from our developments.

     Currently, we have been granted 23 patents in the United States and 23
patents in other countries. We have also made application for a total of 44
patents, both in the United States and other countries. Any patent applications
we may have made or may make relating to our potential products, processes and
technologies may not result in patents being issued. Our current patents may not
be valid or enforceable and may not protect us against competitors that
challenge our patents, obtain patents that may have an adverse effect on our
ability to conduct business or are able to circumvent our patents. Further, we
may not have the necessary financial resources to enforce our patents.

     To protect our trade secrets and proprietary technologies and processes, we
rely, in part, on confidentiality agreements with employees, consultants and
advisors. These agreements may not provide adequate protection for our trade
secrets and other proprietary information in the event of any unauthorized use
or disclosure, or if others lawfully develop the information.

Others may bring infringement claims against us, which could be time-consuming
and expensive to defend


     Third parties may claim that the manufacture, use or sale of our drug
delivery technologies infringe their patent rights. If such claims are asserted,
we may have to seek licenses, defend infringement actions or challenge the
validity of those patents in court. If we cannot obtain required licenses, are
found liable for infringement or are not able to have these patents declared
invalid, we may be liable for significant monetary damages, encounter
significant delays in bringing products to market or be precluded from
participating in the manufacture, use or sale of products or methods of drug
delivery covered by the patents of others. We may not have identified, or be
able to identify in the future, United States or foreign patents that pose a
risk of potential infringement claims.

     Additionally, the drugs to which our drug delivery technologies are applied
are generally the property of the pharmaceutical companies. Those drugs may be
the subject of patents or patent applications and other forms of protection
owned by the pharmaceutical companies or third parties. If those patents or
other forms of protection expire, become ineffective or are subject to the
control of third parties, sales of the drugs by the collaborating pharmaceutical
company may be restricted or may cease. Our revenues, in that event, may
decline.

We may incur significant costs seeking approval for our products, which could
delay the realization of revenue and, ultimately, decrease our revenues from
such products

     The design, development, testing, manufacturing and marketing of
pharmaceutical compounds, medical nutrition and diagnostic products and medical
devices are subject to regulation by governmental authorities, including the FDA
and comparable regulatory authorities in other countries. The approval


                                       9



process is generally lengthy, expensive and subject to unanticipated delays.
Currently, we, along with our partners, are actively pursuing marketing approval
for a number of products from regulatory authorities in other countries and
anticipate seeking regulatory approval from the FDA for products developed
pursuant to the agreement with BioSante. Our revenue and profit will depend, in
part, on the successful introduction and marketing of some or all of such
products by us or our partners. There can be no assurance as to when or whether
such approvals from regulatory authorities will be received.

     Applicants for FDA approval often must submit extensive clinical data and
supporting information to the FDA. Varying interpretations of the data obtained
from pre-clinical and clinical testing could delay, limit or prevent regulatory
approval of a drug product. Changes in FDA approval policy during the
development period, or changes in regulatory review for each submitted new drug
application also may cause delays or rejection of an approval. Even if the FDA
approves a product, the approval may limit the uses or "indications" for which a
product may be marketed, or may require further studies. The FDA also can
withdraw product clearances and approvals for failure to comply with regulatory
requirements or if unforeseen problems follow initial marketing.

     In other jurisdictions, we, and the pharmaceutical companies with whom we
are developing technologies, must obtain required regulatory approvals from
regulatory agencies and comply with extensive regulations regarding safety and
quality. If approvals to market the products are delayed, if we fail to receive
these approvals, or if we lose previously received approvals, our revenues would
be reduced. We may not be able to obtain all necessary regulatory approvals. We
may be required to incur significant costs in obtaining or maintaining
regulatory approvals.

Our business could be harmed if we fail to comply with regulatory requirements
and, as a result, are subject to sanctions

     If we, or pharmaceutical companies with whom we are developing
technologies, fail to comply with applicable regulatory requirements, we, and
the pharmaceutical companies, may be subject to sanctions, including the
following:

     o    warning letters;
     o    fines;
     o    product seizures or recalls;
     o    injunctions;
     o    refusals to permit products to be imported into or exported out of the
          applicable regulatory jurisdiction;
     o    total or partial suspension of production;
     o    withdrawals of previously approved marketing applications; or
     o    criminal prosecutions.

Our revenues may be limited if the marketing claims asserted about our products
are not approved

     Once a drug product is approved by the FDA, the Division of Drug Marketing,
Advertising and Communication, the FDA's marketing surveillance department
within the Center for Drugs, must approve marketing claims asserted by our
pharmaceutical company partners. If a pharmaceutical company partner fails to
obtain from the Division of Drug Marketing acceptable marketing claims for a
product incorporating our drug technologies, our revenues from that product may
be limited. Marketing claims are the basis for a product's labeling, advertising
and promotion. The claims the pharmaceutical company partners are asserting
about our drug delivery technologies, or the drug product itself, may not be
approved by the Division of Drug Marketing.


                                       10




Product liability claims related to participation in clinical trials or the use
or misuse of our products could prove to be costly to defend and could harm our
business reputation

     The testing, manufacturing and marketing of products utilizing our drug
delivery technologies may expose us to potential product liability and other
claims resulting from their use. If any such claims against us are successful,
we may be required to make significant compensation payments. Any
indemnification that we have obtained, or may obtain, from contract research
organizations or pharmaceutical companies conducting human clinical trials on
our behalf may not protect us from product liability claims or from the costs of
related litigation. Similarly, any indemnification we have obtained, or may
obtain, from pharmaceutical companies with whom we are developing drug delivery
technologies may not protect us from product liability claims from the consumers
of those products or from the costs of related litigation. If we are subject to
a product liability claim, our product liability insurance may not reimburse us,
or may not be sufficient to reimburse us, for any expenses or losses that may
have been suffered. A successful product liability claim against us, if not
covered by, or if in excess of the product liability insurance, may require us
to make significant compensation payments, which would be reflected as expenses
on our statement of operations. As the result either of adverse claim experience
or of medical device or insurance industry trends, we may in the future have
difficulty in obtaining product liability insurance or be forced to pay very
high premiums, and there can be no assurance that insurance coverage will
continue to be available on commercially reasonable terms or at all.

Our business could suffer if our competitors develop a superior drug delivery
technology, and we are unable to effectively compete with that technology

     Our success depends, in part, upon maintaining a competitive position in
the development of products and technologies in a rapidly evolving field. If we
cannot maintain competitive products and technologies, our current and potential
pharmaceutical company partners may choose to adopt the drug delivery
technologies of our competitors. Drug delivery companies that compete with our
technologies include Bioject Medical Technologies, Inc., Weston Medical Group
plc, Equidyne Corporation, Bentley Pharmaceuticals, Inc., Cellegy
Pharmaceuticals, Inc., Laboratoires Besins-Iscovesco, MacroChem Corporation,
NexMed, Inc. and Novavax, Inc., along with other companies. We also compete
generally with other drug delivery, biotechnology and pharmaceutical companies
engaged in the development of alternative drug delivery technologies or new drug
research and testing. Many of these competitors have substantially greater
financial, technological, manufacturing, marketing, managerial and research and
development resources and experience than we do, and, therefore, represent
significant competition.

     In general, injection is used only with drugs for which other drug delivery
methods are not possible, in particular with biopharmaceutical proteins (drugs
derived from living organisms, such as insulin and human growth hormone) that
cannot currently be delivered orally, transdermally (through the skin) or
pulmonarily (through the lungs). Transdermal patches and gels are also used for
drugs that cannot be delivered orally. Many companies, both large and small, are
engaged in research and development efforts on novel techniques aimed at
delivering such drugs through the skin, either without needle injection or by
patch and gel. The successful development and commercial introduction of such a
non-injection technique would likely have a material adverse effect on our
business, financial condition, results of operations and general prospects.

     Competitors may succeed in developing competing technologies or obtaining
governmental approval for products before we do. Competitors' products may gain
market acceptance more rapidly than our products. Developments by competitors
may render our products, or potential products, noncompetitive or obsolete.


                                       11



We expect our quarterly revenues and operating results to fluctuate for a number
of reasons, which could cause our stock price to fluctuate

     Our operating results may vary significantly from quarter to quarter, in
part because of changes in consumer buying patterns, aggressive competition, the
timing of the recognition of licensing or development fee payments and the
timing of, and costs related to, any future technology or new drug use
introductions. Our operating results for any particular quarter are not
necessarily indicative of any future results. The uncertainties associated with
the introduction of any new technology or drug use and with general market
trends may limit management's ability to forecast short-term results of
operations accurately. Fluctuations caused by variations in quarterly operating
results or our failure to meet analysts' projections or public expectations as
to results may adversely affect the market price of our Common Stock.

Our business may suffer if we lose certain key officers or employees

     The success of our business is materially dependent upon the continued
services of certain of our key officers and employees. The loss of such key
personnel could have a material adverse effect on our business, operating
results or financial condition. We plan on hiring personnel to work in the areas
of regulatory/clinical, device production and administrative support.
Competition for such personnel is intense, and there can be no assurance that we
will be successful in attracting and retaining key personnel in the future.

We are involved in many international markets, and this subjects us to
additional business risks

     We have offices and a research facility in Basel, Switzerland, and we also
license and distribute our products in the European Community and the United
States. These geographic localities provide economically and politically stable
environments in which to operate. However, in the future, we intend to introduce
products through partnerships in other countries. As we expand our geographic
market, we fill face additional ongoing complexity to our business and may
encounter the following additional risks:

     o    increased complexity and costs of managing international operations;
     o    protectionist laws and business practices that favor local companies;
     o    dependence on local vendors;
     o    multiple, conflicting and changing governmental laws and regulations;
     o    difficulties in enforcing our legal rights;
     o    reduced or limited protections of intellectual property rights; and
     o    political and economic instability.

A significant portion of our international revenues is denominated in foreign
currencies. An increase in the value of the U.S. dollar relative to these
currencies may make our products more expensive and, thus, less competitive in
foreign markets.


                                       12



Future Terrorist Attacks Could Substantially Harm Our Business

     On September 11, 2001, the United States was the target of terrorist
attacks of unprecedented scope. The U.S. government and media agencies were also
subject to subsequent acts of terrorism through the distribution of anthrax
through the mail. Such attacks and the U.S. government's ongoing response may
lead to further acts of terrorism, bio-terrorism and financial and economic
instability. The precise effects of these attacks, future attacks or the U.S.
government's response to the same are difficult to determine, but they could
have an adverse effect on our business, profitability and financial condition.


                        Risks Related to our Common Stock

Our stock price has been, and is likely to continue to be, volatile, which may
result in a loss to our shareholders

     The market price for our common stock has been volatile. As of August 21,
2002, the 52-week low and high sales prices of our common stock reported by the
Nasdaq SmallCap market ranged from $1.59 per share to $5.00 per share. The
trading prices of our common stock could be subject to wide fluctuations in
response to events or factors, many of which are beyond our control. These could
include, without limitation (i) quarter to quarter variations in our operating
results, (ii) announcements by us or our competitors regarding the results of
regulatory approval filings, clinical trials or testing, (iii) developments or
disputes concerning proprietary rights, (iv) technological innovations or new
commercial products, (v) material changes in our collaborative arrangements and
(vi) general conditions in the medical technology industry. Moreover, the stock
market has experienced extreme price and volume fluctuations, which have
particularly affected the market prices of many medical technology and device
companies and which have often been unrelated to the operating performance of
such companies.

All decisions affecting our company are under the control of a single
shareholder who owns a majority of the voting power of our common stock, and
this could lower the price of our common stock

     As a result of our reverse business combination with Permatec in January
2001, Permatec Holding AG and its controlling shareholder, Dr. Jacques Gonella
own a majority of (currently 63.8%) the outstanding shares of our common stock.
Because of Permatec's and Dr. Gonella's control of the Company, investors will
be unable to affect or change the management or the direction of the Company. As
a result, some investors may be unwilling to purchase our common stock. If the
demand for our common stock is reduced because of Permatec's and Dr. Gonella's
control of the Company, the price of our common stock could be materially
depressed.

     Because Permatec and Dr. Gonella own more than 50% of the combined voting
power of our stock, they will be able to generally determine the outcome of all
corporate actions requiring shareholder approval. As a result, Permatec and Dr.
Gonella will be in a position to control all matters affecting our Company,
including decisions as to our corporate direction and policies; future issuances
of our common stock or other securities; our incurrence of debt; amendments to
our articles of incorporation and bylaws; payment of dividends on our common
stock; and acquisitions, sales of our assets, mergers or similar transactions,
including transactions involving a change of control.

Sales of our common stock by our officers and directors may lower the market
price of our common stock

     As of August 23, 2002, our officers and directors beneficially owned an
aggregate of 6,772,234 shares (or 66.5%) of our common stock, including stock
options exercisable within 60 days. If our officers and directors, or other
shareholders, sell a substantial amount of our common stock, it could


                                       13



cause the market price of our common stock to decrease and could hamper our
ability to raise capital through the sale of our equity securities.

Sales of our common stock by the holders of the convertible debentures may lower
the market price of our common stock

     As of August 23, 2002, $1,400,000 principal amount of secured convertible
debentures were issued and outstanding. Investors have agreed to fund an
additional $600,000 of principal amount of convertible debentures upon this
registration statement becoming effective. The debentures are convertible into
such number of shares of common stock as is determined by dividing the principal
amount thereof by the then current conversion price. The per share conversion
price for the debentures is the lower of $2.50 or 75% of the average of the
three lowest intraday trading prices, as reported on the Nasdaq SmallCap Market,
during the twenty trading days prior to the conversion date. If converted on
August 22, 2002, the conversion price would have been $1.47, and the
outstanding debentures would have been convertible into approximately 952,381
shares of common stock, but this number of shares could prove to be
significantly greater in the event of a decrease in the trading price of our
common stock. If the aggregate $2 million principal amount of debentures were
outstanding at August 22, 2002, they would be currently convertible into
1,360,544 shares of our common stock, which could also prove to be significantly
greater in the event of a decrease in the trading price of our common stock.
Purchasers of common stock could therefore experience substantial dilution of
their investment upon conversion of the debentures. In addition, as the per
share conversion price of the debentures into common stock is substantially
lower than the current market price of our common stock, we will be recording an
accounting charge for the beneficial in-the-money conversion feature of the
debentures. This charge will be material to our financial statements and could
equal the principal amount of the converted debentures. The debentures are not
registered and may be sold only if registered under the Securities Act of 1933,
as amended, or sold in accordance with an applicable exemption from
registration, such as Rule 144. The shares of common stock into which the
debentures may be converted are being registered pursuant to this registration
statement.

     As of August 23, 2002, 1,600,000 shares of common stock were reserved for
issuance upon conversion of the debentures. As of August 23, 2002, there were
9,790,325 shares of common stock outstanding. Of these outstanding shares,
3,022,802 shares were freely tradable without restriction under the Securities
Act of 1933, as amended, unless held by affiliates.

We do not expect to pay dividends in the foreseeable future

     We intend to retain all earnings in the foreseeable future for our
continued growth and, thus, do not expect to declare or pay any cash dividends
in the foreseeable future.

Anti-takeover effects of certain by-law provisions and Minnesota law could
discourage, delay or prevent a change in control

     Our articles of incorporation and bylaws along with Minnesota law could
discourage, delay or prevent persons from acquiring or attempting to acquire us.
Our articles of incorporation authorize our board of directors, without action
by our shareholders, to designate and issue preferred stock in one or more
series, with such rights, preferences and privileges as the board of directors
shall determine. In addition, our bylaws grant our board of directors the
authority to adopt, amend or repeal all or any of our bylaws, subject to the
power of the shareholders to change or repeal the bylaws. In addition, our
bylaws limit who may call meetings of our shareholders.


                                       14



     As a public corporation, we are prohibited by the Minnesota Business
Corporation Act, except under certain specified circumstances, from engaging in
any merger, significant sale of stock or assets or business combination with any
shareholder or group of shareholders who own at least 10% of our common stock.


                                 USE OF PROCEEDS

     We will not receive any proceeds from the sale of the shares of our common
stock by the selling shareholders.


                                       15



                              SELLING SHAREHOLDERS

     In connection with a Securities Purchase Agreement dated July 12, 2002, the
selling shareholders purchased, and agreed to purchase, 10% Convertible
Debentures in the aggregate amount of $2,000,000. At the same time, we entered
into a Registration Rights Agreement under which we agreed to register the stock
issuable upon conversion of the debentures. Under the terms of the Registration
Rights Agreement, we agreed to file a registration statement for the conversion
stock within 15 days of the closing of the transaction. We have filed a
registration statement on Form S-3, of which this prospectus is a part, to
register the shares of common stock issuable upon conversion of the debentures
for resale by the selling shareholders to meet this obligation.

     Based on information provided by the selling shareholders, the following
table lists the selling shareholders and other information regarding their
beneficial ownership of the shares of our common stock. The following table sets
forth (i) the number of shares of common stock beneficially owned by each
selling shareholder at August 23, 2002; (ii) the number of shares of common
stock to be offered for resale by each selling shareholder; and (iii) the number
and percentage of outstanding shares of common stock to be held by each selling
shareholder after completion of the offering (assumes the sale of all shares
offered pursuant to this prospectus).



                                        Number of
                                        shares of
                                       Common Stock     Number of
                                       beneficially     shares of         Shares Owned after Completion of
                                         owned at      Common Stock                 Offering (1)
                                         August 23,       to be
   Name                                   2002 (1)      Offered (1)          Number          Percentage
                                                                                 
   AJW Partners, LLC (2)                   110,000        110,000               0                0%
   AJW Offshore, Ltd. (3)                  180,000        180,000               0                0%
   AJW Qualified Partners, LLC (4)         110,000        110,000               0                0%
   Xmark Fund, LP (5)                       93,320         93,320               0                0%
   Xmark Fund, Ltd. (6)                    306,680        306,680               0                0%
   SDS Merchant Fund, LP (7)               400,000        400,000               0                0%
   OTATO Limited Partnership (8)           400,000        400,000               0                0%


----------

(1)  Beneficial ownership is determined in accordance with the rules of the
     Securities and Exchange Commission and generally includes voting or
     investment power with respect to securities. Each entity named in the table
     has sole voting and investment power, exercised by the individuals
     indicated in the following footnotes, with respect to all shares of stock
     listed as owned by such entity.
(2)  AJW Partners, LLC is a private investment fund that is owned by its
     investors and managed by SMS Group, LLC. SMS Group, LLC, of which Corey S.
     Ribotsky is the fund manager, has voting and investment control over the
     shares owned by AJW Partners, LLC.
(3)  AJW Offshore, Ltd. (formerly AJW/New Millennium Offshore, Ltd.) is a
     private investment fund that is managed by First Street Manager II, LLC.
     First Street Manager II, LLC, of which Corey S. Ribotsky is the fund
     manager, has voting and investment control over the shares owned by AJW
     Offshore, Ltd.


                                       16



(4)  AJW Qualified Partners, LLC (formerly Pegasus Capital Partners, LLC) is a
     private investment fund that is owned by its investors and managed by AJW
     Manager, LLC, of which Corey S. Ribotsky and Lloyd A. Groveman are the fund
     managers. AJW Manager, LLC has voting and investment control over the
     shares owned by AJW Qualified Partners, LLC.
(5)  Xmark Fund, L.P., a Delaware limited partnership, is a private investment
     fund that is owned by its investors and managed by its general partner,
     Brown Simpson Capital, L.L.C., a Delaware limited liability company. Brown
     Simpson Capital, L.L.C., of which Mitchell D. Kaye is the managing member,
     has voting and investment control over the shares owned by Xmark Fund, L.P.
(6)  Xmark Fund, Ltd., a Cayman Islands corporation, is a private investment
     fund that is owned by its investors and managed by Brown Simpson Asset
     Management, LLC, a Delaware limited liability company. Brown Simpson Asset
     Management, LLC, of which Mitchell D. Kaye is the managing member, has
     voting and investment control over the shares owned by Xmark Fund, Ltd.
(7)  SDS Merchant Fund, L.P. is a limited partnership of which SDS Capital
     Partners, LLC is the general partner. Steve Darby is the managing member of
     SDS Capital Partners, LLC, and exercises voting and investment control over
     the shares owned by SDS Merchant Fund, L.P.
(8)  OTATO Limited Partnership is a limited partnership for which OTA Grand
     Cayman, Inc., a Delaware corporation, is the general partner. By reason of
     such relationship, OTA Grand Cayman, Inc. may be deemed to share voting the
     dispositive power over the shares of common stock beneficially owned by
     OTATO Limited Partnership. As of August 1, 2002, Messrs. Frederick Berdon
     and Paul Masters, registered representatives of a registered broker-dealer
     at which OTATO Limited Partnership maintains a brokerage account, have
     discretionary authority to trade the shares included in the table. By
     reason of such discretionary authority, these individuals may be deemed to
     share dispositive power over the shares of stock beneficially owned by
     OTATO Limited Partnership.


               CERTAIN INFORMATION ABOUT THE SELLING SHAREHOLDERS

     The number of shares set forth in the table for the selling shareholders
represents a good faith estimate of the number of shares of common stock to be
offered by the selling shareholders. The debentures are convertible at a price
which is the lesser of $2.50 or 75% of the average of the three lowest intraday
trading prices of our common stock, as reported on the Nasdaq SmallCap Market,
for the twenty trading days prior to the conversion date. The actual number of
shares of common stock issuable upon conversion of the debentures is
indeterminate, is subject to adjustment and could be materially less or more
than such estimated number depending on factors which cannot be predicted by us
at this time including, among other factors, the future market price of the
common stock. Under the terms of our Registration Rights Agreement with the
selling shareholders listed herein, we are obligated to register 200% of the
number of shares which may be issued upon conversion of the convertible
debentures held by the selling shareholders. In addition, the actual number of
shares of common stock offered in this prospectus, and included in the
registration statement of which this prospectus is a part, includes such
additional number of shares of common stock as may be issued or issuable upon
conversion of the debentures by reason of any stock split, stock dividend or
similar transaction involving the common stock, in accordance with Rule 416
under the Securities Act of 1933, as amended. Under the terms of the debentures,
if the debentures had actually been converted on August 22, 2002, the conversion
price would have been $1.47.

     Under the terms of the debentures, the debentures are convertible by any
holder only to the extent that the number of shares of common stock issuable
pursuant to such securities, together with the number of shares of common stock
owned by such holder and its affiliates (but not including shares of common
stock underlying unconverted shares of debentures) would not exceed 4.9% of the
then outstanding common stock as determined in accordance with Section 13(d) of
the Exchange Act.


                                       17



                              PLAN OF DISTRIBUTION

     We are registering the resale of certain shares of common stock into which
the debentures are convertible on behalf of the selling shareholders. The
selling shareholders may offer and resell such shares from time to time, either
in increments or in a single transaction. They may also decide not to sell all
the shares they are allowed to resell under this prospectus. The selling
shareholders will act independently of us in making decisions with respect to
the timing, manner and size of each sale.

Donees; Pledgees and Transferees

     The term "selling shareholder" includes donees, i.e., persons who receive
shares from the selling shareholders after the date of this prospectus by gift.
The term also includes pledgees, i.e., persons who upon contractual default by
the selling shareholders may seize shares which the selling shareholders pledged
to such person, and other transferees or successors-in-interest.

Types of Sale Transactions

     The selling shareholders may sell the shares in one or more types of
transactions (which may include block transactions):

     o    on the Nasdaq SmallCap Market or any national securities exchange or
          other U.S. inter-dealer system of a registered national securities
          association on which the common stock may be listed or quoted at the
          time of sale;
     o    in the over-the-counter market;
     o    in negotiated transactions;
     o    through option transactions, whether the options are listed on an
          options exchange or otherwise;
     o    through settlement of short sales; or
     o    any combination of such methods of sale.

     The selling shareholders may enter into hedging transactions with third
parties, which may in turn engage in short sales of the common stock into which
the debentures are convertible in the course of hedging the position they
assume. The selling shareholders may also enter into short positions or other
derivative transactions relating to the common stock into which the debentures
are convertible, or interests in the common stock, and deliver the common stock,
or interests in the common stock, to close out their short or other positions or
otherwise settle short sales or other transactions, or loan or pledge the common
stock into which the debentures are convertible, or interests in the common
stock, to third parties that in turn may dispose of these securities.

     The shares may be sold at market prices prevailing at the time of sale, or
at negotiated prices. Such transactions may or may not involve underwriters,
brokers or dealers. The selling shareholders have informed us that they have not
entered into any agreements, understandings or arrangements with any
underwriters or broker-dealers regarding the sale of the shares. They have also
informed us that no one is acting as underwriter or coordinating broker in
connection with the proposed sale of shares. The selling shareholders shall have
the sole and absolute discretion not to accept any purchase offer or make any
sale of shares if they deem the purchase price to be unsatisfactory at any
particular time.


                                       18



Costs and Commissions

     We will not receive any proceeds from the sale of the stock by the selling
shareholders and will bear all costs, fees and expenses incident to our
obligation to register the shares of common stock issuable upon conversion of
the debentures under the terms of the registration rights agreement. The selling
shareholders will pay all brokerage commissions and similar selling expenses, if
any, attributable to the sale of the shares.

Sales to or through Underwriters and Broker-Dealers

     The selling shareholders may conduct such transactions either by selling
shares directly to purchasers, or by selling shares to, or through underwriters
or broker-dealers. Such underwriters or broker-dealers may act either as an
agent of the selling shareholders, or as a principal for their own account. Such
underwriters or broker-dealers may receive compensation in the form of
discounts, concessions, or commissions from the selling shareholders and/or the
purchasers of the shares. This compensation might also exceed customary
commissions.

Deemed Underwriting Compensation

     The selling shareholders and any third parties that act in connection with
the sale of shares may be deemed to be "underwriters" within the meaning of
Section 2(a)(11) of the Securities Act. Any discounts, commissions, concessions
or profits they earn on the disposition of the shares of common stock may be
deemed to be underwriting discounts or commissions under the Securities Act. The
selling shareholders have purchased the shares of our common stock in the
ordinary course of his business, and at the time the selling shareholders
purchased the shares of common stock, they were not a party to any agreement or
other understanding to distribute the shares, directly or indirectly.

Indemnification

     We have agreed to indemnify the selling shareholders against certain
liabilities, including liabilities arising under the Securities Act or to
contribute to payments the selling shareholders may be required to make in
respect of such liabilities. The selling shareholders may agree to indemnify any
underwriter, agent or broker-dealer that participates in transactions involving
sales of shares against certain liabilities, including liabilities under the
Securities Act.

Prospectus Delivery Requirements

     Because they may be deemed to be underwriters, the selling shareholders
must deliver this prospectus and any supplements to this prospectus in the
manner required by the Securities Act. This might include delivery through the
facilities of the Nasdaq SmallCap Market in accordance with Rule 153 of the
Securities Act. In addition, the selling shareholders' sales in the market may
be subject to the antimanipulative provisions of Regulation M under the
Securities Exchange Act of 1934, as amended, or the Exchange Act. These
provisions may restrict certain activities of, and limit the timing of purchases
and sales of any of the shares by, the selling shareholders or any other such
person. Furthermore, under Regulation M, persons engaged in a distribution of
securities are prohibited form simultaneously engaging in market making and
certain other activities with respect to such securities for a specified period
of time prior to the commencement of such distributions, subject to specified
exceptions or exemptions. Such limitations may affect the marketability of the
shares.


                                       19



State Requirements

     Some states require that any shares sold in that state may only be sold
through registered or licensed brokers or dealers. In addition, some states
require that the shares have been registered or qualified for sale in that
state, or that an exemption exists from the registration or qualification
requirement and that the exemption or qualification requirements have been
complied with.

Sales under Rule 144

     The selling shareholders may also resell all or a portion of their shares
in open market transactions in reliance upon Rule 144 under the Securities Act.
To do so, they must meet the criteria and conform to the requirements of Rule
144.

Distribution Arrangements

     If a selling shareholder notifies us that any material arrangement has been
entered into with an underwriter, broker-dealer or agent for the sale of shares
through a

     o    block trade;
     o    special offering;
     o    exchange distribution or secondary distribution, or
     o    purchase by an underwriter or broker-dealer,

we will then file, if required, a supplement to this prospectus under Rule
424(b) under the Securities Act.

     The supplement will disclose the following:

     o    the name of the selling shareholder and of the participating
     o    underwriter(s) or broker-dealer(s),
     o    the number of shares involved;
     o    the price at which such shares are sold;
     o    the commissions paid or discounts or concessions allowed to such
          underwriter(s) or broker-dealer(s), where applicable;
     o    that such underwriter(s) or broker-dealer(s) did not conduct any
          investigation to verify the information in this prospectus; and
     o    any other facts material to the transaction.


                                  LEGAL MATTERS

     For the purpose of this offering, Leonard, Street and Deinard Professional
Association, Minneapolis, Minnesota is giving an opinion of the validity of the
issuance of the securities offered in this prospectus.


                                     EXPERTS

     The consolidated financial statements and schedule of Antares Pharma, Inc.
as of December 31, 2000 and 2001 and for each of the years in the three-year
period ended December 31, 2001 have been incorporated by reference herein and in
the registration statement in reliance upon the reports of KPMG LLP, independent
certified public accountants, incorporated by reference herein, and upon the
authority of said firm as experts in accounting and auditing.


                                       20



     The audit report covering the December 31, 2001, consolidated financial
statements contains an explanatory paragraph that states that the Company's
negative working capital, recurring losses and negative cash flows from
operations raise substantial doubt about the entity's ability to continue as a
going concern. The consolidated financial statements do not include any
adjustments that might result from the outcome of that uncertainty.

     The audit report covering the December 31, 2001, consolidated financial
statements refers to a change to the cumulative deferral method of revenue
recognition for licensing arrangements in 2000.


                                 INDEMNIFICATION

     Minnesota Statutes Section 302A.521 provides that a corporation shall
indemnify any person made or threatened to be made a party to a proceeding by
reason of the former or present official capacity of such person against
judgments, penalties, fines (including, without limitation, excise taxes
assessed against such person with respect to any employee benefit plan),
settlements and reasonable expenses, including attorneys' fees and
disbursements, incurred by such person in connection with the proceeding, if,
with respect to the acts or omissions of such person complained of in the
proceeding, such person

     o    has not been indemnified therefor by another organization or employee
          benefit plan;
     o    acted in good faith;
     o    received no improper personal benefit and Section 302A.255 (with
          respect to director conflicts of interest), if applicable, has been
          satisfied;
     o    in the case of a criminal proceeding, had no reasonable cause to
          believe the conduct was unlawful; and
     o    reasonably believed that the conduct was in the best interests of the
          corporation in the case of acts or omissions in such person's official
          capacity for the corporation or reasonably believed that the conduct
          was not opposed to the best interests of the corporation in the case
          of acts or omissions in such person's official capacity for other
          affiliated organizations.

     Article 7 of our Third Amended and Restated Articles of Incorporation
provides that we will indemnify directors to the fullest extent permitted by the
Minnesota Business Corporation Act as now enacted or hereafter amended.

     We also maintain an insurance policy to assist in funding indemnification
of directors and officers for certain liabilities.

     Insofar as indemnification for liabilities arising under the Securities Act
may be permitted to directors, officers or persons controlling our company
pursuant to the foregoing provisions, we have been informed that in the opinion
of the SEC such indemnification is against public policy as expressed in the
Securities Act and is therefore unenforceable.


                       WHERE YOU CAN FIND MORE INFORMATION

     We file annual, quarterly and current reports, proxy statements and other
information with the SEC. Our filings are available to the public over the
internet at the SEC's web site at http://www.sec.gov. You may also read and copy
any document we file at the SEC's Public Reference Rooms in Washington, D.C.,
New York, New York, and Chicago, Illinois. A Public Reference Room is located at
450 Fifth Street, N.W., Washington, D.C. 20549. Please call the SEC at
1-800-SEC-0330 for additional information on the Public Reference Rooms.


                                       21



PART II

INFORMATION NOT REQUIRED IN PROSPECTUS

ITEM 14. OTHER EXPENSES OF ISSUANCE AND DISTRIBUTION

     The following table sets forth the costs and expenses, other than
underwriting discounts and commissions, payable by us in connection with the
sale of common stock being registered. All amounts, except the SEC registration
fee, are estimates.

SEC Registration Fee ...........................    $611.00
Legal Fees and Expenses ........................   5,000.00
Accounting Fees and Expenses ...................  25,000.00
Miscellaneous ..................................     889.00
                                                 ----------
  Total ........................................ $31,500.00
                                                 ==========


ITEM 15. INDEMNIFICATION OF DIRECTORS AND OFFICERS

     Minnesota Statutes Section 302A.521 provides that a corporation shall
indemnify any person made or threatened to be made a party to a proceeding by
reason of the former or present official capacity of such person against
judgments, penalties, fines (including, without limitation, excise taxes
assessed against such person with respect to any employee benefit plan),
settlements and reasonable expenses, including attorneys' fees and
disbursements, incurred by such person in connection with the proceeding, if,
with respect to the acts or omissions of such person complained of in the
proceeding, such person:

     o    has not been indemnified therefor by another organization or employee
          benefit plan;
     o    acted in good faith;
     o    received no improper personal benefit and Section 302A.255 (with
          respect to director conflicts of interest), if applicable, has been
          satisfied;
     o    in the case of a criminal proceeding, had no reasonable cause to
          believe the conduct was unlawful; and
     o    reasonably believed that the conduct was in the best interests of the
          corporation in the case of acts or omissions in such person's official
          capacity for the corporation or reasonably believed that the conduct
          was not opposed to the best interests of the corporation in the case
          of acts or omissions in such person's official capacity for other
          affiliated organizations.

     Article 7 of our Third Amended and Restated Articles of Incorporation
provides that we will indemnify directors to the fullest extent permitted by the
Minnesota Business Corporation Act as now enacted or hereafter amended.

     We also maintain an insurance policy to assist in funding indemnification
of directors and officers for certain liabilities.


                                       II-1




ITEM 16. EXHIBITS

EXHIBIT
NUMBER                                DOCUMENT
------                                --------
4.1*           Form of our Common Stock Certificate.
5.1+           Opinion of Leonard, Street and Deinard Professional Association.
10.29#         Securities Purchase Agreement, dated July 12, 2002, between
               Antares Pharma, Inc. and AJW Partners, LLC; AJW/New Millennium
               Offshore, Ltd.; Pegasus Capital Partners, LLC; XMark Fund, L.P.;
               XMark Fund, Ltd.; SDS Merchant Fund, LP; and OTATO Limited
               Partnership.
10.30#         Registration Rights Agreement, dated July 12, 2002, between
               Antares Pharma, Inc. and AJW Partners, LLC; AJW/New Millennium
               Offshore, Ltd.; Pegasus Capital Partners, LLC; XMark Fund, L.P.;
               XMark Fund, Ltd.; SDS Merchant Fund, LP; and OTATO Limited
               Partnership.
10.31#         Security Agreement, dated July 12, 2002, between Antares Pharma,
               Inc. and AJW Partners, LLC; AJW/New Millennium Offshore, Ltd.;
               Pegasus Capital Partners, LLC; XMark Fund, L.P.; XMark Fund,
               Ltd.; SDS Merchant Fund, LP; and OTATO Limited Partnership.
10.32#         Form of Secured Convertible Debenture, dated July 12, 2002.
23.1           Consent of KPMG LLP, Independent Certified Public Accountants.
23.2+          Consent of Leonard, Street and Deinard Professional Association
               (included in Exhibit 5.1).
24.1+          Power of Attorney (See page II-4).

*    Previously filed as an exhibit to our Form S-3, filed with the SEC on May
     31, 2001, and incorporated herein by reference.
#    Previously filed as an exhibit to our Form 8-K, filed with the SEC on July
     17, 2002, and incorporated herein by reference.
+    Previously filed as an exhibit to our Form S-3, filed with the SEC on July
     19, 2002,and incorporated herein by reference.

ITEM 17. UNDERTAKINGS

     (a) The undersigned registrant hereby undertakes:

     (1)  To file, during any period in which offers or sales are being made, a
          post-effective amendment to this registration statement

          (i) to include any prospectus required by Section 10(a)(3) of the
          Securities Act of 1933;

          (ii) to reflect in the prospectus any facts or events arising after
          the effective date of the registration statement (or the most recent
          post-effective amendment thereof) which, individually or in the
          aggregate, represent a fundamental change in the information set forth
          in the registration statement. Notwithstanding the foregoing, any
          increase or decrease in volume of securities offered (if the total
          dollar value of securities offered would not exceed that which was
          registered) and any deviation from the low or high end of the
          estimated maximum offering


                                       II-2



          range may be reflected in the form of prospectus filed with the
          Commission pursuant to Rule 424(b) if, in the aggregate, changes in
          volume and price represent no more than a 20 percent change in the
          maximum aggregate offering price set forth in the "Calculation of
          Registration Fee" table in the effective registration statement;

          (iii) to include any material information with respect to the plan of
          distribution not previously disclosed in the registration statement or
          any material change to such information in the registration statement.

     (2)  That, for the purpose of determining any liability under the
          Securities Act, each such post-effective amendment shall be deemed to
          be a new registration statement relating to the securities offered
          therein, and the offering of such securities at that time shall be
          deemed to be the initial bona fide offering thereof.

     (3)  To remove from registration by means of a post-effective amendment any
          of the securities being registered which remain unsold at the
          termination of the offering.

     (b) The undersigned registrant hereby undertakes that, for purposes of
determining any liability under the Securities Act, each filing of the
registrant's annual report pursuant to Section 13(a) or Section 15(d) of the
Exchange Act and, where applicable, each filing of an employee benefit plan's
annual report pursuant to Section 15(d) of the Exchange Act that is incorporated
by reference in the registration statement shall be deemed to be a new
registration statement relating to the securities offered therein, and the
offering of such securities at that time shall be deemed to be the initial bona
fide offering thereof.

     (c) Insofar as indemnification for liabilities arising under the Securities
Act may be permitted to directors, officers and controlling persons of the
registrant pursuant to the foregoing provisions, or otherwise, the registrant
has been advised that in the opinion of the SEC such indemnification is against
public policy as expressed in the Securities Act and is, therefore
unenforceable. In the event that a claim for indemnification against such
liabilities (other than the payment by the registrant of expenses incurred or
paid by a director, officer or controlling person of the registrant in the
successful defense of any action, suit or proceeding) is asserted by such
director, officer or controlling person in connection with the securities being
registered, the registrant will, unless in the opinion of its counsel the matter
has been settled by controlling precedent, submit to a court of appropriate
jurisdiction the question whether such indemnification by it is against public
policy as expressed in the Securities Act and will be governed by the final
adjudication of such issue.


                                       II-3



                                   SIGNATURES

     Pursuant to the requirements of the Securities Act of 1933, the registrant
certifies that it has reasonable grounds to believe that it meets all of the
requirements for filing on Form S-3 and has duly caused this registration
statement to be signed on its behalf by the undersigned, thereunto duly
authorized, in the city of Exton, Pennsylvania, on August 23, 2002.

                                      ANTARES PHARMA, INC.

                                      By: /s/ Roger G. Harrison, Ph.D.
                                          --------------------------------------
                                          Roger G. Harrison, Ph.D.
                                          Chief Executive Officer





        Signature                                           Title                                  Date
        ---------                                           -----                                  ----
                                                                                         
/s/ Roger G. Harrison, Ph.D.                 Chief Executive Officer and Director              August 23, 2002
-------------------------------              (principal executive officer)
Roger G. Harrison, Ph.D.

/s/ Lawrence M. Christian                    Vice President of Finance,                        August 23, 2002
-------------------------------              Chief Financial Officer and Secretary
Lawrence M. Christian                        (principal financial and accounting officer)

           *                                 Director, Chairman of the Board                   August 23, 2002
-------------------------------
Dr. Jacques Gonella

           *                                 Director, Vice Chairman of the Board              August 23, 2002
-------------------------------
Franklin Pass, M.D.

           *                                 Director                                          August 23, 2002
-------------------------------
James Clark

           *                                 Director                                          August 23, 2002
-------------------------------
Prof. Ubaldo Conte

           *                                 Director                                          August 23, 2002
-------------------------------
Dr. Philippe Dro

           *                                 Director                                          August 23, 2002
-------------------------------
Kenneth Evenstad

           *                                 Director                                          August 23, 2002
-------------------------------
Dr. Thomas Rinderknecht

           *                                 Director                                          August 23, 2002
-------------------------------
John Gogol

           *                                 Director                                          August 23, 2002
-------------------------------
Jacques Rejeange

*By: /s/ Roger G. Harrison, Ph.D.                                                              August 23, 2002
     ----------------------------
         Attorney-in-Fact




                                       II-4




                                INDEX TO EXHIBITS

EXHIBIT
NUMBER                                      DOCUMENT

4.1*           Form of our Common Stock Certificate.
5.1+           Opinion of Leonard, Street and Deinard Professional Association.
10.29#         Securities Purchase Agreement, dated July 12, 2002, between
               Antares Pharma, Inc. and AJW Partners, LLC; AJW/New Millennium
               Offshore, Ltd.; Pegasus Capital Partners, LLC; XMark Fund, L.P.;
               XMark Fund, Ltd.; SDS Merchant Fund, LP; and OTATO Limited
               Partnership.
10.30#         Registration Rights Agreement, dated July 12, 2002, between
               Antares Pharma, Inc. and AJW Partners, LLC; AJW/New Millennium
               Offshore, Ltd.; Pegasus Capital Partners, LLC; XMark Fund, L.P.;
               XMark Fund, Ltd.; SDS Merchant Fund, LP; and OTATO Limited
               Partnership.
10.31#         Security Agreement, dated July 12, 2002, between Antares Pharma,
               Inc. and AJW Partners, LLC; AJW/New Millennium Offshore, Ltd.;
               Pegasus Capital Partners, LLC; XMark Fund, L.P.; XMark Fund,
               Ltd.; SDS Merchant Fund, LP; and OTATO Limited Partnership.
10.32#         Form of Secured Convertible Debenture, dated July 12, 2002.
23.1           Consent of KPMG LLP, Independent Certified Public Accountants.
23.2+          Consent of Leonard, Street and Deinard Professional Association
               (included in Exhibit 5.1).
24.1+          Power of Attorney (See page II-4).

----------
*    Previously filed as an exhibit to our Form S-3, filed with the SEC on May
     31, 2001, and incorporated herein by reference.
#    Previously filed as an exhibit to our Form 8-K, filed with the SEC on July
     17, 2002, and incorporated herein by reference.
+    Previously filed as an exhibit to our Form S-3, filed with the SEC on July
     19, 2002, and incorporated herein by reference.