As Filed with the Securities and Exchange Commission on March 21, 2003

                                                Registration No. 333-

================================================================================

                       Securities and Exchange Commission
                             Washington, D.C. 20549

                            ------------------------

                                    Form S-3
                             Registration Statement
                                      Under
                           The Securities Act of 1933

                            ------------------------

                              Antares Pharma, Inc.
             (Exact Name of Registrant as Specified in its Charter)

              Minnesota                               41-1350192
    (State or Other Jurisdiction                   (I.R.S. Employer
 of Incorporation or Organization)              Identification Number)

                             707 Eagleview Boulevard
                                    Suite 414
                                 Exton, PA 19341
                                 (610) 458-6200
               (Address, Including Zip Code, and Telephone Number,
       Including Area Code, of Registrant's Principal Executive Offices)

                            ------------------------

                            Roger G. Harrison, Ph.D.
                             Chief Executive Officer
                              Antares Pharma, Inc.
                             707 Eagleview Boulevard
                                    Suite 414
                                 Exton, PA 19341
                                 (610) 458-6200
                     (Name, Address, Including Zip Code, and
          Telephone Number, Including Area Code, of Agent for Service)

                            ------------------------

APPROXIMATE DATE OF COMMENCEMENT OF PROPOSED SALE TO THE PUBLIC: From time to
time after this registration statement becomes effective.

If the only securities being registered on this Form are being offered pursuant
to dividend or interest reinvestment plans, please check the following box. [ ]

If any of the securities being registered on this Form are to be offered on a
delayed or continuous basis pursuant to Rule 415 under the Securities Act of
1933, other than securities offered only in connection with dividend or interest
reinvestment plans, check the following box. [X]



If this Form is filed to register additional securities for an offering pursuant
to Rule 462(b) under the Securities Act, please check the following box and list
the Securities Act registration statement number of the earlier effective
registration statement for the same offering. [ ] __________

If this Form is a post-effective amendment filed pursuant to Rule 462(c) under
the Securities Act, check the following box and list the Securities Act
registration statement number of the earlier effective registration statement
for the same offering. [ ] __________

If delivery of the prospectus is expected to be made pursuant to Rule 434,
please check the following box. [ ]

                         CALCULATION OF REGISTRATION FEE
================================================================================
   TITLE OF                           PROPOSED       PROPOSED
  EACH CLASS                          MAXIMUM        MAXIMUM
OF SECURITIES                         OFFERING       AGGREGATE    AMOUNT OF
    TO BE           AMOUNT TO BE      PRICE PER      OFFERING    REGISTRATION
  REGISTERED       REGISTERED (1)     SHARE (2)       PRICE          FEE
--------------------------------------------------------------------------------
Common Stock,
par value $.01
per share            4,511,518          $0.53     $2,391,105.00     $220
================================================================================

(1) Includes shares of common stock which may be offered pursuant to this
registration statement, which shares are issuable upon conversion of secured
convertible debentures and exercise of warrants. The number of shares of common
stock registered hereunder represents a good faith estimate by the Company of
the number of shares of common stock issuable upon conversion of the debentures
and exercise of the warrants. This registration statement shall also cover any
additional shares of common stock which become issuable by reason of any stock
dividend, stock split, recapitalization or other similar transaction which
results in an increase in the number of the outstanding shares of common stock
in accordance with Rule 416.

(2) This estimate is made pursuant to Rule 457(c) of the Securities Act of 1933,
as amended, solely for purposes of determining the registration fee. The above
calculation is based on the average of the high and low sales price of the
Registrant's common stock on the Nasdaq SmallCap Market on Thursday, March 19,
2003.

The Registrant hereby amends this Registration Statement on such date or dates
as may be necessary to delay its effective date until the Registrant files a
further amendment which specifically states that this Registration Statement
shall thereafter become effective in accordance with Section 8(a) of the
Securities Act of 1933, as amended, or until this Registration Statement shall
become effective on such date as the Securities and Exchange Commission, acting
pursuant to such Section 8(a), may determine.

================================================================================



********************************************************************************
The information in this prospectus is not complete and may be changed. The
selling securityholders may not sell these securities until the registration
statement filed with the Securities and Exchange Commission is effective. This
prospectus is not an offer to sell these securities and it is not soliciting an
offer to buy these securities in any state where the offer or sale is not
permitted.
********************************************************************************

                   SUBJECT TO COMPLETION, DATED MARCH 21, 2003

                             PRELIMINARY PROSPECTUS

                               4,511,518 SHARES OF

                              ANTARES PHARMA, INC.

                                  COMMON STOCK

         This prospectus relates to the offering of 4,511,518 shares of our
common stock which may be sold from time to time by the selling shareholders
named in this prospectus.

         The shares of our common stock are being registered to permit the
selling shareholders to sell the shares from time to time in the public market.
The shareholders may sell the shares in negotiated transactions or otherwise, at
market prices prevailing at the time of sale or at negotiated prices. The timing
and amount of any sale are within the sole discretion of the selling
shareholders. In addition, the shares may be offered from time to time through
ordinary brokerage transactions, directly to market makers of our shares or
through any other means described in the section entitled "Plan of Distribution"
beginning on page 21.

We will not receive any of the proceeds from the sale of the shares although we
have paid the the expenses of preparing this prospectus and the related
registration expenses. Securities and Our common stock is quoted on the Nasdaq
SmallCap Market under the symbol "ANTR." The last Exchange reported sales price
of our common stock on the Nasdaq SmallCap Market on March 19, 2003 was $0.53
per Commission share.

        BEFORE PURCHASING ANY OF THE SHARES COVERED BY THIS PROSPECTUS,
          YOU SHOULD CAREFULLY READ AND CONSIDER THE RISK FACTORS AND
         UNCERTAINTIES DISCUSSED IN THE SECTION ENTITLED "RISK FACTORS"
       BEGINNING ON PAGE 3. YOU SHOULD BE PREPARED TO ACCEPT ANY AND ALL
        OF THE RISKS ASSOCIATED WITH PURCHASING THE SHARES, INCLUDING A
                            LOSS OF YOUR INVESTMENT.

                            -------------------------

          NEITHER THE SECURITIES AND EXCHANGE COMMISSION NOR ANY STATE
           SECURITIES REGULATORS HAS APPROVED OR DISAPPROVED OF THESE
           SECURITIES OR DETERMINED IF THIS PROSPECTUS IS TRUTHFUL OR
           COMPLETE. ANY REPRESENTATION TO THE CONTRARY IS A CRIMINAL
                                    OFFENSE.

                 The date of this prospectus is ______ __, 2003



                           FORWARD LOOKING STATEMENTS

         This prospectus and the documents incorporated by reference herein
contain forward-looking statements within the meaning of the securities laws.
These forward-looking statements are subject to a number of risks and
uncertainties, many of which are beyond our control. All statements other than
statements of historical facts included or incorporated by reference in this
prospectus regarding our strategy, future operations, financial position,
estimated revenues, projected costs, prospects, plans and objectives of
management are forward-looking statements. When used in this prospectus, the
words "will," "believe," "anticipate," "intend," "estimate," "expect," "project"
and similar expressions are intended to identify forward-looking statements,
although not all forward-looking statements contain such identifying words. All
forward-looking statements speak only as of the date of this prospectus. Neither
we nor the selling shareholders undertake any obligation to update or revise
publicly any forward-looking statements, whether as a result of new information,
future events or otherwise. Although we believe that our plans, intentions and
expectations reflected in or suggested by the forward-looking statements that we
make in this prospectus are reasonable, we can give no assurance that such
plans, intentions or expectations will be achieved. The cautionary statements
qualify all forward-looking statements attributable to us or persons acting on
our behalf.

                           INCORPORATION BY REFERENCE

         The SEC allows us to "incorporate by reference" the information we file
with them, which means that we can disclose important information to you by
referring you to those documents. The information incorporated by reference is
an important part of this prospectus, and information that we file later with
the SEC will automatically update and supersede this information. We incorporate
by reference into this prospectus and refer you to the documents listed below:

         o        our Annual Report on Form 10-K for the fiscal year ended
                  December 31, 2002, filed with the SEC on March 21, 2003;

         o        the description of our common stock contained in our
                  registration statement on Form S-1/A, filed on August 15,
                  1996, including any amendment or report filed for the purpose
                  of updating the description; and

         o        any future filings we will make with the SEC under Sections
                  13(a), 13(c), 14 or 15(d) of the Exchange Act after the date
                  of this registration statement and prior to the filing of a
                  post-effective amendment that indicates that all shares
                  offered have been sold or which deregisters all shares then
                  remaining unsold.

         This prospectus is part of a registration statement on Form S-3 filed
with the SEC under the Securities Act. This prospectus does not contain all of
the information set forth in the registration statement. You should read the
registration statement for further information about our company and the common
stock.


                                       i



         You may request, orally or in writing, a copy of these filings. We will
provide the copies of these filings to you at no cost. Please direct your
requests to:

                              Antares Pharma, Inc.
                             707 Eagleview Boulevard
                                    Suite 414
                            Exton, Pennsylvania 19341
                            Attn: Lawrence Christian
                                 (610) 458-6200

You may also find information about us at our website:
http://www.antarespharma.com. You should rely only on the information
incorporated by reference or provided in this prospectus or any prospectus
supplement. We have not authorized anyone else to provide you with different
information. You should not assume that the information in this prospectus or
any prospectus supplement is accurate as of any date other than the date on the
front page of those documents.

              RECENT DEVELOPMENTS REGARDING ISSUANCE OF SECURITIES

         Because our common stock is listed on the Nasdaq SmallCap Market, we
are subject to the NASD Nasdaq Marketplace Rules. Marketplace Rule 4350(i)(1)(D)
requires that we obtain shareholder approval for any issuance of our common
stock at a price below the market price where the amount of stock being issued
exceeds 20% or more of the common stock or 20% or more of the voting power
outstanding before the issuance. This registration statement is being filed to
register the shares of common stock issuable upon the conversion of convertible
debentures and the exercise of warrants we recently issued. We intend to call a
special meeting of our shareholders in April 2003 to request shareholder
approval for the issuance of the shares of our common stock upon conversion of
the debentures and exercise of the warrants.


                                       ii



                                TABLE OF CONTENTS

Forward Looking Statements ............................................    i

Incorporation by Reference ............................................    i

Recent Developments Regarding Issuance of Securities ..................   ii

Summary ...............................................................    1

Risk Factors ..........................................................    3

Use of Proceeds .......................................................   17

Selling Shareholders ..................................................   17

Certain Information About the Selling Shareholders ....................   21

Plan of Distribution ..................................................   21

Legal Matters .........................................................   24

Experts ...............................................................   24

Indemnification .......................................................   25

Where You Can Find More Information ...................................   26



                                      iii



                                     SUMMARY

Introduction

         The following summary does not contain all of the information that may
be important to you. You should read the entire prospectus, including the
financial statements and other information incorporated by reference in this
prospectus, before making an investment decision.

         The terms "company," "Antares," "registrant," "we," "us," and "our" in
this prospectus refer to Antares Pharma, Inc.

The Company and our Business

         We were incorporated in Minnesota on January 31, 1979 under the name
Derata Corporation. We changed our name to Medi-Ject Corporation on November 16,
1992. On January 31, 2001, we completed a business combination to acquire the
three operating subsidiaries of Permatec Holding AG, headquartered in Basel,
Switzerland. Prior to the closing of the business combination, we did not have
sufficient funds to continue our operations, and we had determined that it was
necessary to, among other things, either raise more capital or merge with
another biopharmaceutical company. Medi-Ject was a company focused on delivery
of drugs across the skin using needle free technology, and Permatec specialized
in delivery of drugs across the skin using transdermal patch and gel
technologies. Given that both groups were focused on delivery of drugs across
the skin, but with a focus on different sectors, we believed that a business
combination would be attractive to both pharmaceutical partners and to our
shareholders.

         The business combination transaction with the Permatec subsidiaries was
accounted for as a reverse merger because upon the closing of the transaction,
Permatec owned in excess of 67% of the outstanding shares of our common stock.
The historical financial statements of Permatec thus became those of the
company. Upon consummation of the transaction, the acquired Permatec
subsidiaries were renamed Antares Pharma AG, Antares Pharma IPL AG and Antares
Pharma NV, and we changed our name to Antares Pharma, Inc. The following
discussion of our business includes our operations following the transaction
with Permatec.

         We develop, manufacture and market medical devices, called jet
injectors, that allow people to self-inject drugs without using a needle. These
jet injectors utilize a small spring-action device and attached disposable
plastic syringes to hold the drug. A liquid drug is drawn up into the syringe
through a small hole at the end. When the syringe is held against the body and
the spring is released, a piston drives the fluid stream into the tissues
beneath the skin. A person may re-arm the device and repeat the process or
attach a new sterile syringe between injections. Recently we have developed a
variation of our jet injector by adding a very small hidden needle to a
pre-filled, single-use injector. With the Permatec combination, we are also
involved in other methods of drug delivery, including trandsdermal patches and
topical gel formulations.

         We operate in the specialized drug delivery sector of the
pharmaceutical industry. Companies in this sector generally bring technology and
know-how in the area of drug



formulation (in our case, injection devices) to pharmaceutical manufacturers
through licensing and development agreements. Our principal customers are
pharmaceutical manufacturers. We have negotiated and executed licensing
relationships in the growth hormone segment (needle-free devices in Europe and
Asia), the hormone replacement segment (transdermal delivery of estradiol in
South America) and topical hormone gels segment (several development programs in
place worldwide). In addition, we continue to market needle-free devices for the
home administration of insulin in the U.S. and international markets as we seek
a distribution relationship with an insulin manufacturer.

         Our principal executive office is located at 707 Eagleview Boulevard,
Suite 414, Exton, Pennsylvania 19341, and our telephone number at that office is
(610) 458-6200. We have wholly-owned subsidiaries in Switzerland (Antares Pharma
AG and Antares Pharma IPL AG) and the Netherlands Antilles (Antares Pharma NV).
Our United States research and manufacturing facility is located in Minneapolis,
Minnesota.


                                       -2-



                                  RISK FACTORS

         You should consider carefully the following information about risks,
together with the other information contained in this prospectus and in the
documents referred to below in "Where You Can Find More Information," before you
decide whether to buy our common stock. Additional risks and uncertainties not
known to us or that we now believe to be not material could also impair our
business. If any of the following risks actually occur, our business, results of
operations and financial condition could suffer significantly. As a result, the
market price of our common stock could decline and you could lose all of your
investment.

                          Risks Related to Our Business

We only have sufficient cash to continue operations for two to three weeks

         Our cash position is currently only sufficient to fund working capital
requirements for the next two to three weeks. Moreover, we have no immediate
access to additional capital. While we received a total of EURO1,500,000
(approximately $1,600,000) from Ferring BV in connection with our license
agreement, those funds will not last beyond March 2003. We expect our working
capital needs over the next 12 months to approximate $9.7 million. This amount
consists of approximately $3.4 million for research and development, $500,000
for business development, $300,000 for marketing and sales, $400,000 for
regulatory and quality assurance and $5.1 million for general and administrative
expenses, which is partially offset by approximately $8.0 million of projected
license fees and net product margins. As a result, we continue to seek funds
through additional equity or debt offerings, equity investments by our strategic
partners/customers and divestment of certain non-core technologies. There can be
no assurance that sufficient additional equity or debt financing will be
available. If we cannot obtain financing when needed, or obtain it on favorable
terms, we may be required to curtail development of new drug technologies,
further reduce operating costs through staff reductions or cease operations
altogether. Additionally, even if we are able to raise additional capital and
continue our operations, if our Swiss subsidiaries do not generate sufficient
cash flow on their own or the U.S. parent company is unable to provide funds to
them, and these Swiss subsidiaries are therefore deemed technically insolvent,
Swiss laws may require us to place the balance sheet of the Swiss subsidiaries
into the Swiss courts. Such an action is often a precursor to a bankruptcy
filing, and may be deemed an event of default under our debentures.

         Because of insufficient cash flows, we were also several days late in
satisfying our U.S. operations payroll obligations for January 31, 2003. There
can be no assurance that we will raise additional funds or receive sufficient
monthly revenue payments to prevent this from occurring again.

If we default on the terms of the debentures we recently issued, the debenture
holders will be able to foreclose on their lien on our assets for the amount of
indebtedness we owe them

         We currently have an aggregate of $1,613,255 outstanding principal
amount of our 8% Senior Secured Convertible Debentures and Amended and Restated
8% Senior Secured Convertible Debentures. These debentures earn interest at a
rate of 8% per annum and mature on March 31, 2004. Interest is payable
quarterly, and the debenture holders have the option of receiving the interest
payments in cash or in shares of our common stock. In the event these debentures
are not converted prior to March 31, 2004, we will be required to repay the
principal and any accrued but previously unpaid interest. We do not currently
have the ability to repay the principal on these debentures, nor do we have any
assurance that we will have adequate funds to


                                       -3-



repay them when they mature. We granted to the holders of the debentures a
security interest in substantially all of our assets. Therefore, if we default
on the terms of the debentures, the debenture holders will be able to take title
to a substantial portion of our assets, up to the amount of indebtedness we owe
them.

We have incurred significant losses to date, and for our last fiscal year we
received an opinion from our accountants expressing substantial doubt about our
ability to continue as a going concern

         The report of our independent accountants in our Annual Report on Form
10-K for the fiscal year ended December 31, 2002, contains an explanatory
paragraph expressing substantial doubt about our ability to continue as a going
concern as a result of recurring losses and negative cash flows from operations.
We had negative working capital of ($11,712) and ($4,188,234) at December 31,
2001 and 2002, respectively. We incurred net losses of ($5,260,387),
($9,499,101) and ($11,608,765) in the fiscal years ended 2000, 2001 and 2002,
respectively. In addition, we have accumulated aggregate net losses from the
inception of business through December 31, 2002, of ($41,165,798).

         The costs for research and product development of our drug delivery
technologies along with marketing and selling expenses and general and
administrative expenses have been the principal causes of our losses. We
reported a net loss for the year ended December 31, 2002, as marketing and
development costs related to bringing future generations of products to market
continue. Long-term capital requirements will depend on numerous factors,
including, but not limited to, the status of collaborative arrangements, the
progress of research and development programs and the receipt of revenues from
sales of products. Our ability to achieve and/or sustain profitable operations
depends on a number of factors, many of which are beyond our control. These
factors include, but are not limited to, the following:

         o        the demand for our technologies from current and future
                  biotechnology and pharmaceutical partners;
         o        our ability to manufacture products efficiently and with the
                  required quality;
         o        our ability to increase manufacturing capacity to allow for
                  new product introductions;
         o        the level of product competition and of price competition;
         o        our ability to develop additional commercial applications for
                  our products;
         o        our ability to obtain regulatory approvals;
         o        our ability to control costs; and
         o        general economic conditions.

We depend on a limited number of customers for the majority of our revenue, and
the loss of any one of these customers could substantially reduce our revenue

         During fiscal 2002, we derived approximately 79% of our revenue from
the following two customers:


                                       -4-



         o        Ferring Pharmaceutical NV (approximately 49%)
         o        BioSante Pharmaceuticals, Inc. (approximately 30%)

The loss of either of these customers would cause revenues to decrease
significantly, increase our continuing losses from operations and, ultimately,
could require us to cease operating. If we cannot broaden our customer base, we
will continue to depend on a few customers for the majority of our revenues. We
may be unable to negotiate favorable business terms with customers that
represent a significant portion of our revenues. If that occurs, our revenues
and gross profits may be insufficient to allow us to achieve and/or sustain
profitability or continue operations.

If we or our third-party manufacturer are unable to supply Ferring BV with our
devices pursuant to our current license agreement with Ferring, Ferring would
own a fully paid up license for certain of our intellectual property

         Pursuant to our license agreement with Ferring BV, we licensed certain
of our intellectual property related to our needle-free injection devices,
including granting a license allowing Ferring to manufacture our devices on its
own for use with its human growth hormone product. This license becomes
effective if we are unable to continue to supply product to Ferring under our
current supply agreement. In accordance with the license agreement, we entered
into a manufacturing agreement with a third party to manufacture our devices for
Ferring. If we or this third party are unable to meet our obligations to supply
Ferring with our devices, Ferring would own a fully paid up license to
manufacture our devices and to use and exploit our intellectual property in
connection with Ferring's human growth hormone product. In such event, we would
no longer receive royalty revenues from Ferring, and we would no longer be able
to license such technology to other parties for use in the field of human growth
hormone therapy.

We have limited manufacturing experience and may experience manufacturing
difficulties related to the use of new materials and procedures, which could
increase our production costs and, ultimately, decrease our profits

         Our past assembly, testing and manufacturing experience for certain of
our technologies has involved the assembly of products from machined stainless
steel and composite components in limited quantities. Our planned future drug
delivery technologies necessitate significant changes and additions to our
manufacturing and assembly process to accommodate new components. These systems
must be manufactured in compliance with regulatory requirements, in a timely
manner and in sufficient quantities while maintaining quality and acceptable
manufacturing costs. In the course of these changes and additions to our
manufacturing and production methods, we may encounter difficulties, including
problems involving yields, quality control and assurance, product reliability,
manufacturing costs, existing and new equipment, component supplies and
shortages of personnel, any of which could result in significant delays in
production. Additionally, we recently entered into a manufacturing agreement
under which a third party will assemble certain component parts of our MJ6B and
MJ7 devices. There can be no assurance that this third party manufacturer will
be able to meet these regulatory requirements or our own quality control
standards. Therefore, there can be no assurance that we will be able to


                                       -5-



successfully produce and manufacture our drug delivery technology. Any failure
to do so would negatively impact our business, financial condition and results
of operations.

Our products have achieved only limited acceptance by patients and physicians,
which continues to have a negative effect on our revenue

         Our business ultimately depends on ultimate patient and physician
acceptance of our needle-free injectors, gels and our other drug delivery
technologies as an alternative to more traditional forms of drug delivery,
including injections using a needle and transdermal patch products. To date, our
device technologies have achieved only limited acceptance from such parties.
Transdermal gels from other companies appear to be gaining increasing
acceptance, but there is no guarantee that this will also be seen with our gel
products when they are commercialized. If our drug delivery technologies are not
accepted in the marketplace, we may be unable to successfully attract additional
marketing partners or directly market and sell our products, which would limit
our ability to generate revenues and to achieve and/or sustain profitability.
The degree of acceptance of our drug delivery systems depends on a number of
factors. These factors include, but are not limited to, the following:

         o        demonstrated clinical efficacy, safety and enhanced patient
                  compliance;
         o        cost-effectiveness;
         o        convenience and ease of use of injectors and transdermal gels;
         o        advantages over alternative drug delivery systems or similar
                  products from other companies; and
         o        marketing and distribution support.

Physicians may refuse to prescribe products incorporating our drug delivery
technologies if they believe that the active ingredient is better administered
to a patient using alternative drug delivery technologies, that the time
required to explain use of the technologies to the patient would not be offset
by advantages, or they believe that the delivery method will result in patient
noncompliance. Factors such as patient perceptions that a gel is inconvenient to
apply or that devices do not reproducibly deliver the drug may cause patients to
reject our drug delivery technologies. Because only a limited number of products
incorporating our drug delivery technologies are commercially available, we
cannot yet fully assess the level of market acceptance of our drug delivery
technologies.

If transdermal gels do not achieve market acceptance, we may be unable to
achieve sufficient profits from this technology.

         Because transdermal gels are a newer, less understood method of drug
delivery, our potential consumers have little experience with manufacturing
costs or pricing parameters. Our assumption of higher value may not be shared by
the consumer. To date, transdermal gels have gained successful entry into only a
limited number of markets. There can be no assurance that transdermal gels will
ever gain sufficient market acceptance in those or other markets to achieve
and/or sustain profitable operations.


                                       -6-



Our injectable depot gel technology may not achieve consumer acceptance and, as
a result, may not result in revenues for our company.

         Although the injectable depot gel research field is active, few
products have reached the market. There is no data indicating that the specific
depot gel formulations we are researching will be accepted. Regulatory
compliance and approvals can take a substantial amount of time due to clinical
evaluations that are required for this type of drug delivery method. There can
be no assurance that injectable gels will ever obtain the necessary regulatory
approvals or gain sufficient market acceptance to achieve and/or sustain
profitable operations.

A recent FDA study questioned the safety of hormone replacement therapy for
menopausal women, and our female hormone replacement therapy business may suffer
as a result

         In July 2002, the Federal Drug Administration halted a long-term study
being conducted on oral female hormone replacement therapy (HRT) using a
combination of estradiol and progestin because the study showed an increased
risk of breast cancer, heart disease and blood clots in women taking HRT. The
studies using estradiol alone were not halted. The halted study looked at only
one brand of oral combined HRT, and there is no information on whether other
brands with different levels of hormones would carry the same risks. In January
2003, the FDA announced that it would be requiring new warnings on the labels
for HRT products, and it advised patients to consult with their doctors about
whether to use continuous combined HRT and to limit the period of use to help
manage post-menopausal vasomotor symptoms, not to manage osteoporosis or other
possible longer-term indications. These results and recommendations have had an
impact on the use of HRT, but we cannot predict whether sales will remain at
this reduced level, or whether our own transdermal HRT contracts will continue
as more information on the effects of HRT is released. Additionally, there is no
information at this point regarding whether the transdermal gels and patches
that we market for HRT will be shown to carry the same risks as those found in
the study.

We rely on third parties to supply components for our products, and any failure
to retain relationships with these third parties could negatively impact our
ability to manufacture our products

         Certain of our technologies contain a number of customized components
manufactured by various third parties. Regulatory requirements applicable to
medical device and transdermal patch manufacturing can make substitution of
suppliers costly and time-consuming. In the event that we could not obtain
adequate quantities of these customized components from our suppliers, there can
be no assurance that we would be able to access alternative sources of such
components within a reasonable period of time, on acceptable terms or at all.
The unavailability of adequate quantities, the inability to develop alternative
sources, a reduction or interruption in supply or a significant increase in the
price of components could have a material adverse effect on our ability to
manufacture and market our products.


                                       -7-



We may be unable to successfully expand into new areas of drug delivery
technology, which could substantially reduce our revenue and negatively impact
our business as a whole

         We intend to continue to enhance our current technologies. Even if
enhanced technologies appear promising during various stages of development, we
may not be able to develop commercial applications for them because

         o        the potential technologies may fail clinical studies;
         o        we may not find a pharmaceutical company to adopt the
                  technologies;
         o        it may be difficult to apply the technologies on a commercial
                  scale;
         o        the technologies may not be economical to market; or
         o        we may not receive necessary regulatory approvals for the
                  potential technologies.

We have not yet completed research and development work or obtained regulatory
approval for any technologies for use with any drugs other than insulin, human
growth hormone and estradiol. There can be no assurance that any newly developed
technologies will ultimately be successful or that unforeseen difficulties will
not occur in research and development, clinical testing, regulatory submissions
and approval, product manufacturing and commercial scale up, marketing, or
product distribution related to any such improved technologies or new uses. Any
such occurrence could materially delay the commercialization of such improved
technologies or new uses or prevent their market introduction entirely.

As health insurance companies and other third-party payors increasingly
challenge the products and services for which they will provide coverage, our
individual consumers may be unable to afford to use our products, which could
substantially reduce our revenues

         Our injector device products are currently sold in the European
Community (EC) and in the United States for use with human growth hormone or
insulin. In the case of human growth hormone, our products are provided to users
at no cost by the drug manufacturer. In the United States the injector products
are only available for use with insulin.

         Although it is impossible for us to identify the amount of sales of our
products that our customers will submit for payment to third-party insurers, at
least some of these sales may be dependent in part on the availability of
adequate reimbursement from these third-party healthcare payors. Currently,
insurance companies and other third-party payors reimburse the cost of certain
technologies on a case-by-case basis and may refuse reimbursement if they do not
perceive benefits to the technologies' use in a particular case. Third-party
payors are increasingly challenging the pricing of medical products and
services, and there can be no assurance that such third-party payors will not in
the future increasingly reject claims for coverage of the cost of certain of our
technologies. Insurance and third party payor practice vary from country to
country, and changes in practices could negatively affect our business if the
cost burden for our technologies were shifted more to the patient. Therefore,
there can be no assurance that adequate levels of reimbursement will be
available to enable us to achieve or maintain market acceptance of our
technologies or maintain price levels sufficient to realize profitable
operations. There is also a possibility of increased government control or
influence over a broad range of healthcare


                                       -8-



expenditures in the future. Any such trend could negatively impact the market
for our drug delivery technologies.

The loss of any existing licensing agreements or the failure to enter into new
licensing agreements could substantially affect our revenue

         Our business plans require us to enter into license agreements with
pharmaceutical and biotechnology companies covering the development,
manufacture, use and marketing of drug delivery technologies with specific drug
therapies. Under these arrangements, the partner company is to assist us in the
development of systems for such drug therapies and collect or sponsor the
collection of the appropriate data for submission for regulatory approval of the
use of the drug delivery technology with the licensed drug therapy. Our
licensees will also be responsible for distribution and marketing of the
technologies for these drug therapies either worldwide or in specific
territories. We are currently a party to a number of such agreements, all of
which are currently in varying stages of development. Although none of our
collaborative agreements have been terminated for failure to meet milestones, we
may not be able to meet future milestones established in our agreements (such
milestones generally being structured around satisfactory completion of certain
phases of clinical development, regulatory approvals and commercialization of
our product) and thus, would not receive the fees expected from such
arrangements. Moreover, there can be no assurance that we will be successful in
executing additional collaborative agreements or that existing or future
agreements will result in increased sales of our drug delivery technologies. In
such event, our business, results of operations and financial condition could be
adversely affected, and our revenues and gross profits may be insufficient to
allow us to achieve and/or sustain profitability. As a result of our
collaborative agreements, we are dependent upon the development, data collection
and marketing efforts of our licensees. The amount and timing of resources such
licensees devote to these efforts are not within our control, and such licensees
could make material decisions regarding these efforts that could adversely
affect our future financial condition and results of operations. In addition,
factors that adversely impact the introduction and level of sales of any drug
covered by such licensing arrangements, including competition within the
pharmaceutical and medical device industries, the timing of regulatory or other
approvals and intellectual property litigation, may also negatively affect sales
of our drug delivery technology.

The failure of any of our third-party licensees to develop, obtain regulatory
approvals for, market, distribute and sell our products could substantially
reduce our revenue

         Pharmaceutical company partners help us develop, obtain regulatory
approvals for, manufacture and sell our products. If one or more of these
pharmaceutical company partners fail to pursue the development or marketing of
the products as planned, our revenues and gross profits may not reach
expectations or may decline. We may not be able to control the timing and other
aspects of the development of products because pharmaceutical company partners
may have priorities that differ from ours. Therefore, commercialization of
products under development may be delayed unexpectedly. We do not intend to have
a direct marketing channel to consumers for our drug delivery technologies
except through current distributor agreements in the United States for our
insulin delivery device. Therefore, the success of the marketing organizations
of the pharmaceutical company partners, as well as the level of priority
assigned to


                                       -9-



the marketing of the products by these entities, which may differ from our
priorities, will determine the success of the products incorporating our
technologies. Competition in this market could also force us to reduce the
prices of our technologies below currently planned levels, which could adversely
affect our revenues and future profitability.

We face increasing competition, and our business could suffer if we are unable
to effectively compete with our competitor's technology

         Additional competitors in the needle-free injector market, some with
greater resources and experience than us, may enter the market, as there is an
increasing recognition of a need for less invasive methods of injecting drugs.
Similarly, several companies are competing in the transdermal gel market. Our
success depends, in part, upon maintaining a competitive position in the
development of products and technologies in a rapidly evolving field. If we
cannot maintain competitive products and technologies, our current and potential
pharmaceutical company partners may choose to adopt the drug delivery
technologies of our competitors. Drug delivery companies that compete with our
technologies include Bioject Medical Technologies, Inc., Equidyne Corporation,
Bentley Pharmaceuticals, Inc., Cellegy Pharmaceuticals, Inc., Laboratoires
Besins-Iscovesco, MacroChem Corporation, NexMed, Inc. and Novavax, Inc., along
with other companies. We also compete generally with other drug delivery,
biotechnology and pharmaceutical companies engaged in the development of
alternative drug delivery technologies or new drug research and testing. Many of
these competitors have substantially greater financial, technological,
manufacturing, marketing, managerial and research and development resources and
experience than we do, and, therefore, represent significant competition.

         In general, injection is used only with drugs for which other drug
delivery methods are not possible, in particular with biopharmaceutical proteins
(drugs derived from living organisms, such as insulin and human growth hormone)
that cannot currently be delivered orally, transdermally (through the skin) or
pulmonarily (through the lungs). Transdermal patches and gels are also used for
drugs that cannot be delivered orally or where oral delivery has other
limitations (such as high first pass drug metabolism). Many companies, both
large and small, are engaged in research and development efforts on less
invasive methods of delivering drugs that cannot be taken orally. The successful
development and commercial introduction of such a non-injection technique would
likely have a material adverse effect on our business, financial condition,
results of operations and general prospects.

         Competitors may succeed in developing competing technologies or
obtaining governmental approval for products before we do. Competitors' products
may gain market acceptance more rapidly than our products, or may be priced more
favorably than our products. Developments by competitors may render our
products, or potential products, noncompetitive or obsolete.


                                       -10-



If we are unable to raise additional capital to continue operating, we may be
unable to realize the value we have attributed to our goodwill, patents and
intellectual property

         Currently, our most valuable assets on our balance sheet are our
goodwill from the acquisition of Mediject of $1,095,355, patents and
intellectual property of $2,157,174 related to our devices and transdermal gels.
We have valued these assets in accordance with generally accepted accounting
principles. If we are not able to raise additional capital to continue our
operations, we may be unable to continue licensing these patents, and would not
receive any additional revenue from them. Additionally, we may be required to
sell our patents and intellectual property to a third party. In such event, the
purchase price we receive for our patents and intellectual property may be
substantially lower than the value we have attributed to them in our financial
statements.

We have applied for, and have received, several patents, and we may be unable to
protect our intellectual property, which would negatively affect our ability to
compete

         Our success depends, in part, on our ability to obtain and enforce
patents for our products, processes and technologies and to preserve our trade
secrets and other proprietary information. If we cannot do so, our competitors
may exploit our innovations and deprive us of the ability to realize revenues
and profits from our developments.

         Currently, we have been granted 25 patents in the United States and 30
patents in other countries. We have also made application for a total of 90
patents, both in the United States and other countries. Any patent applications
we may have made or may make relating to our potential products, processes and
technologies may not result in patents being issued. Our current patents may not
be valid or enforceable and may not protect us against competitors that
challenge our patents, obtain patents that may have an adverse effect on our
ability to conduct business or are able to circumvent our patents. Further, we
may not have the necessary financial resources to enforce our patents.

         To protect our trade secrets and proprietary technologies and
processes, we rely, in part, on confidentiality agreements with employees,
consultants and advisors. These agreements may not provide adequate protection
for our trade secrets and other proprietary information in the event of any
unauthorized use or disclosure, or if others lawfully develop the information.

Others may bring infringement claims against us, which could be time-consuming
and expensive to defend

         Third parties may claim that the manufacture, use or sale of our drug
delivery technologies infringe their patent rights. If such claims are asserted,
we may have to seek licenses, defend infringement actions or challenge the
validity of those patents in court. If we cannot obtain required licenses, are
found liable for infringement or are not able to have these patents declared
invalid, we may be liable for significant monetary damages, encounter
significant delays in bringing products to market or be precluded from
participating in the manufacture, use or sale of products or methods of drug
delivery covered by the patents of others. We may not have identified, or be
able to identify in the future, United States or foreign patents that pose a
risk of potential infringement claims.


                                       -11-



         Additionally, the drugs to which our drug delivery technologies are
applied are generally the property of the pharmaceutical companies. Those drugs
may be the subject of patents or patent applications and other forms of
protection owned by the pharmaceutical companies or third parties. If those
patents or other forms of protection expire, become ineffective or are subject
to the control of third parties, sales of the drugs by the collaborating
pharmaceutical company may be restricted or may cease. Our revenues, in that
event, may decline.

We may incur significant costs seeking approval for our products, which could
delay the realization of revenue and, ultimately, decrease our revenues from
such products

         The design, development, testing, manufacturing and marketing of
pharmaceutical compounds, medical nutrition and diagnostic products and medical
devices are subject to regulation by governmental authorities, including the FDA
and comparable regulatory authorities in other countries. The approval process
is generally lengthy, expensive and subject to unanticipated delays. Currently,
we, along with our partners, are actively pursuing marketing approval for a
number of products from regulatory authorities in other countries and anticipate
seeking regulatory approval from the FDA for products developed pursuant to our
agreement with BioSante. Our revenue and profit will depend, in part, on the
successful introduction and marketing of some or all of such products by our
partners or us. There can be no assurance as to when or whether such approvals
from regulatory authorities will be received.

         Applicants for FDA approval often must submit extensive clinical data
and supporting information to the FDA. Varying interpretations of the data
obtained from pre-clinical and clinical testing could delay, limit or prevent
regulatory approval of a drug product. Changes in FDA approval policy during the
development period, or changes in regulatory review for each submitted new drug
application also may cause delays or rejection of an approval. Even if the FDA
approves a product, the approval may limit the uses or "indications" for which a
product may be marketed, or may require further studies. The FDA also can
withdraw product clearances and approvals for failure to comply with regulatory
requirements or if unforeseen problems follow initial marketing.

         In other jurisdictions, we, and the pharmaceutical companies with whom
we are developing technologies, must obtain required regulatory approvals from
regulatory agencies and comply with extensive regulations regarding safety and
quality. If approvals to market the products are delayed, if we fail to receive
these approvals, or if we lose previously received approvals, our revenues would
be reduced. We may not be able to obtain all necessary regulatory approvals. We
may be required to incur significant costs in obtaining or maintaining
regulatory approvals.

Our business could be harmed if we fail to comply with regulatory requirements
and, as a result, are subject to sanctions

         If we, or pharmaceutical companies with whom we are developing
technologies, fail to comply with applicable regulatory requirements, the
pharmaceutical companies, and we, may be subject to sanctions, including the
following:


                                       -12-



         o        warning letters;
         o        fines;
         o        product seizures or recalls;
         o        injunctions;
         o        refusals to permit products to be imported into or exported
                  out of the applicable regulatory jurisdiction;
         o        total or partial suspension of production;
         o        withdrawals of previously approved marketing applications; or
         o        criminal prosecutions.

Our revenues may be limited if the marketing claims asserted about our products
are not approved

         Once a drug product is approved by the FDA, the Division of Drug
Marketing, Advertising and Communication, the FDA's marketing surveillance
department within the Center for Drugs, must approve marketing claims asserted
by our pharmaceutical company partners. If a pharmaceutical company partner
fails to obtain from the Division of Drug Marketing acceptable marketing claims
for a product incorporating our drug technologies, our revenues from that
product may be limited. Marketing claims are the basis for a product's labeling,
advertising and promotion. The claims the pharmaceutical company partners are
asserting about our drug delivery technologies, or the drug product itself, may
not be approved by the Division of Drug Marketing.

Product liability claims related to participation in clinical trials or the use
or misuse of our products could prove to be costly to defend and could harm our
business reputation

         The testing, manufacturing and marketing of products utilizing our drug
delivery technologies may expose us to potential product liability and other
claims resulting from their use. If any such claims against us are successful,
we may be required to make significant compensation payments. Any
indemnification that we have obtained, or may obtain, from contract research
organizations or pharmaceutical companies conducting human clinical trials on
our behalf may not protect us from product liability claims or from the costs of
related litigation. Similarly, any indemnification we have obtained, or may
obtain, from pharmaceutical companies with whom we are developing drug delivery
technologies may not protect us from product liability claims from the consumers
of those products or from the costs of related litigation. If we are subject to
a product liability claim, our product liability insurance may not reimburse us,
or may not be sufficient to reimburse us, for any expenses or losses that may
have been suffered. A successful product liability claim against us, if not
covered by, or if in excess of the product liability insurance, may require us
to make significant compensation payments, which would be reflected as expenses
on our statement of operations. As the result either of adverse claim experience
or of medical device or insurance industry trends, we may in the future have
difficulty in obtaining product liability insurance or be forced to pay very
high premiums, and there can be no assurance that insurance coverage will
continue to be available on commercially reasonable terms or at all.


                                       -13-



Our business may suffer if we lose certain key officers or employees

         The success of our business is materially dependent upon the continued
services of certain of our key officers and employees. The loss of such key
personnel could have a material adverse effect on our business, operating
results or financial condition. There can be no assurance that we will be
successful in retaining key personnel.

We are involved in many international markets, and this subjects us to
additional business risks

         We have offices and a research facility in Basel, Switzerland, and we
also license and distribute our products in the European Community and the
United States. These geographic localities provide economically and politically
stable environments in which to operate. However, in the future, we intend to
introduce products through partnerships in other countries. As we expand our
geographic market, we fill face additional ongoing complexity to our business
and may encounter the following additional risks:

         o        increased complexity and costs of managing international
                  operations;
         o        protectionist laws and business practices that favor local
                  companies;
         o        dependence on local vendors;
         o        multiple, conflicting and changing governmental laws and
                  regulations;
         o        difficulties in enforcing our legal rights;
         o        reduced or limited protections of intellectual property
                  rights; and
         o        political and economic instability.

         A significant portion of our international revenues is denominated in
foreign currencies. An increase in the value of the U.S. dollar relative to
these currencies may make our products more expensive and, thus, less
competitive in foreign markets.

Future Terrorist Attacks Could Substantially Harm Our Business

         On September 11, 2001, the United States was the target of terrorist
attacks of unprecedented scope. The U.S. government and media agencies were also
subject to subsequent acts of terrorism through the distribution of anthrax
through the mail. Such attacks and the U.S. government's ongoing response may
lead to further acts of terrorism, bio-terrorism and financial and economic
instability. The precise effects of these attacks, future attacks or the U.S.
government's response to the same are difficult to determine, but they could
have an adverse effect on our business, profitability and financial condition.


                                       -14-



                        Risks Related to our Common Stock

We recently received a notice from Nasdaq regarding our failure to comply with
Nasdaq's listing standards, and our stock will be delisted by Nasdaq if our
stock price does not significantly improve by the end of May 2003 or if our net
equity does not meet Nasdaq's continued listing standards

         Our stock is currently traded on the Nasdaq SmallCap Market. Under
Nasdaq's listing maintenance standards, if the closing bid price of a company's
common stock remains under $1.00 per share for 30 consecutive trading days,
Nasdaq will issue a deficiency notice to that company. On November 29, 2002, we
received such a notice from Nasdaq. Pursuant to Nasdaq's notice, we have 180
days, or until May 28, 2003, for our closing bid price to reach $1.00 per share
for a minimum of ten consecutive trading days, or our stock will be delisted.

         In order to avoid a delisting of our common stock, we may be required
to take various measures including effecting a reverse split of our common price
for our common stock. The history of similar stock split combinations for a
company in like circumstances is often not positive. There is no assurance that
the market price per share of our common stock following a reverse stock split
will either exceed or remain in excess of the $1.00 minimum bid price as
required by Nasdaq. Furthermore, the liquidity of our common stock could be
adversely affected by the reduced number of shares that would be outstanding
after a reverse stock split.

         Even if we are able to improve our stock price to regain compliance,
the Nasdaq rules also state that for continued inclusion, we must meet one of
three financial tests, which are having stockholders' equity of $2.5 million,
market value of listed securities of $35 million or net income from operations
of $500,000. As of March 19, 2003, we do not meet any of the above requirements.
In the event we do not improve our stock price to regain compliance, Nasdaq will
determine whether we meet the initial listing criteria for the SmallCap market,
which generally include financial requirements more stringent than those listed
above for continued inclusion on Nasdaq. If we meet the initial listing
criteria, Nasdaq will grant us an additional 180 days to demonstrate compliance.
However, as of March 19, 2003, we do not meet any of these requirements.

         If our stock is delisted and thus no longer eligible for quotation on
the Nasdaq SmallCap Market, it may trade in the over-the-counter market, which
is viewed by most investors as a less desirable and less liquid marketplace. The
loss of our listing on the Nasdaq SmallCap Market would also complicate
compliance with state blue-sky laws. Furthermore, our ability to raise
additional capital would be severely impaired. As a result of these factors, the
value of the common stock would decline significantly. Finally, the failure of
our stock to be listed on the Nasdaq SmallCap Market would constitute a breach
of the covenants we made pursuant to the sale of our 8% debentures, and,
therefore, would constitute an event of default under the debentures and allow
the debenture holders to declare the debentures immediately due and payable. In
such event, we would be required to pay to the debenture holders 130% of the
outstanding principal.


                                       -15-



All decisions affecting our company are under the control of a single
shareholder who currently owns a majority of the voting power of our common
stock, and this could lower the price of our common stock

         As a result of our reverse business combination with Permatec in
January 2001, Permatec Holding AG and its controlling shareholder, Dr. Jacques
Gonella own a majority of (currently approximately 53%) the outstanding shares
of our common stock. Because of Permatec's and Dr. Gonella's control of the
Company, investors will be unable to affect or change the management or the
direction of the Company. As a result, some investors may be unwilling to
purchase our common stock. If the demand for our common stock is reduced because
of Permatec's and Dr. Gonella's control of the Company, the price of our common
stock could be materially depressed.

         Additionally, as a result of our recent debt restructuring, we issued
convertible debentures and warrants to Xmark Fund, Ltd., Xmark Fund, L.P. and
SDS Merchant Fund, LP. These debentures and warrants could ultimately be
converted into or exercised for an aggregate of 6,159,011 shares of our common
stock. In such event, these funds would own in excess of 34% of our common
stock.

         Because the parties described above either currently own or could
potentially own a large portion of our stock, they will be able to generally
determine the outcome of all corporate actions requiring shareholder approval.
As a result, these parties will be in a position to control all matters
affecting our company, including decisions as to our corporate direction and
policies; future issuances of our common stock or other securities; our
incurrence of debt; amendments to our articles of incorporation and bylaws;
payment of dividends on our common stock; and acquisitions, sales of our assets,
mergers or similar transactions, including transactions involving a change of
control.

Sales of our common stock by our officers and directors may lower the market
price of our common stock

         As of March 19, 2003, our officers and directors beneficially owned an
aggregate of 6,821,942 shares (or approximately 55%) of our common stock,
including stock options exercisable within 60 days. If our officers and
directors, or other shareholders, sell a substantial amount of our common stock,
it could cause the market price of our common stock to decrease and could hamper
our ability to raise capital through the sale of our equity securities.

Sales of our common stock by the holders of the 8% debentures and warrant
holders may lower the market price of our common stock

         As of March 19, 2003, $1,613,255 principal amount of 8% debentures were
issued and outstanding. Based on the current conversion price of $.50 per share,
the debentures are convertible into an aggregate of 3,226,511 shares of common
stock. The holders of the 8% debentures also hold warrants exercisable for up to
2,932,500 shares of our common stock. Purchasers of common stock could therefore
experience substantial dilution of their investment upon conversion of the
debentures or exercise of the warrants. The debentures and warrants are not
registered and may be sold only if registered under the Securities Act of 1933,
as amended,


                                       -16-



or sold in accordance with an applicable exemption from registration, such as
Rule 144. Certain of the shares of common stock into which the debentures may be
converted are currently registered and may be sold without restriction. The
remaining shares of common stock into which the debentures and warrants may be
converted or exercised are being registered pursuant to this registration
statement.

         As of March 19, 2003, 6,159,011 shares of common stock were reserved
for issuance upon conversion of the debentures and exercise of the warrants. As
of March 19, 2003, there were 11,887,506 shares of common stock outstanding. Of
these outstanding shares, 5,054,483 shares were freely tradable without
restriction under the Securities Act of 1933, as amended, unless held by
affiliates.

We do not expect to pay dividends in the foreseeable future

         We intend to retain all earnings in the foreseeable future for our
continued growth and, thus, do not expect to declare or pay any cash dividends
in the foreseeable future.

Anti-takeover effects of certain by-law provisions and Minnesota law could
discourage, delay or prevent a change in control

         Our articles of incorporation and bylaws along with Minnesota law could
discourage, delay or prevent persons from acquiring or attempting to acquire us.
Our articles of incorporation authorize our board of directors, without action
by our shareholders, to designate and issue preferred stock in one or more
series, with such rights, preferences and privileges as the board of directors
shall determine. In addition, our bylaws grant our board of directors the
authority to adopt, amend or repeal all or any of our bylaws, subject to the
power of the shareholders to change or repeal the bylaws. In addition, our
bylaws limit who may call meetings of our shareholders.

         As a public corporation, we are prohibited by the Minnesota Business
Corporation Act, except under certain specified circumstances, from engaging in
any merger, significant sale of stock or assets or business combination with any
shareholder or group of shareholders who own at least 10% of our common stock.

                                 USE OF PROCEEDS

         We will not receive any proceeds from the sale of the shares of our
common stock by the selling shareholders.

                              SELLING SHAREHOLDERS

         In connection with a Securities Purchase Agreement dated July 12, 2002,
we sold our 10% Secured Convertible Debentures to four primary investors. On
January 24, 2003 and January 31, 2003, we borrowed an aggregate of $621,025 from
Xmark Fund, LP and Xmark Fund, Ltd. to repurchase the 10% debentures held by AJW
Partners, LLC, AJW Offshore, Ltd., AJW Qualified Partners, LLC and OTATO Limited
Partnership. The repurchase price included


                                       -17-



accrued interest and a premium paid to these investors. In connection with the
repurchase, we also issued to the AJW funds warrants to purchase 79,200 shares
of our common stock. On February 7, 2003, pursuant to a Debenture and Warrant
Purchase Agreement, in exchange for the surrender and cancellation of the
promissory notes we issued the Xmark funds when we borrowed these funds, we
issued to the Xmark funds 8% Senior Secured Convertible Debentures in the same
principal amount as the promissory notes.

         Pursuant to a separate Debenture and Warrant Purchase Agreement dated
the same date, we also issued Amended and Restated 8% Senior Secured Debentures
in the aggregate principal amount of $992,230 to the Xmark funds and SDS
Merchant Fund, LP, another of the original four primary holders of the 10%
debentures, in exchange for the surrender by them of the remaining 10%
debentures. All of the 8% debentures are convertible into shares of our common
stock at a per share price of $.50. We also issued to the Xmark funds and to SDS
warrants to purchase an aggregate of 2,932,500 shares of our common stock at an
exercise price of $.55 per share.

         At the time of the July 12, 2002 transaction, we registered the shares
of our common stock issuable upon conversion of the 10% debentures. On February
18, 2003, we filed a supplemental prospectus to that registration statement to
reflect the repurchase of a portion of the debentures and the issuance of the
Amended and Restated 8% debentures. In connection with the issuance of the 8%
debentures in exchange for the surrender of the promissory notes by the Xmark
funds, and the issuance of the warrants to the Xmark funds and SDS, we entered
into a Registration Rights Agreement under which we agreed to register the stock
issuable upon conversion of the 8% debentures and the stock issuable upon
exercise of the warrants. We have filed a registration statement on Form S-3, of
which this prospectus is a part, to register the shares of common stock issuable
upon conversion of the debentures and exercise of the warrants for resale by the
selling shareholders to meet this obligation.

         Based on information provided by the selling shareholders, the
following table lists the selling shareholders and other information regarding
their beneficial ownership of the shares of our common stock. The following
table sets forth (i) the number of shares of common stock beneficially owned by
each selling shareholder at March 19, 2003, assuming full conversion of the 8%
debentures, full exercise of the warrants and full conversion of the Amended and
Restated 8% Secured Convertible Debentures (which shares are registered pursuant
to the effective registration statement (Registration No. 33-96739)); (ii) the
number of shares of common stock to be offered for resale by each selling
shareholder pursuant to this prospectus; and (iii) the number and percentage of
outstanding shares of common stock to be held by each selling shareholder after
completion of the offering (assumes the sale of all shares offered pursuant to
this prospectus and pursuant to the effective registration statement
(Registration No. 33-96739) covering the resale of certain shares of common
stock issuable upon conversion of the debentures).


                                       -18-





                               Number of shares                            Shares Owned after
                               of Common Stock                                Completion of
                              beneficially owned    Number of shares        Offering (1)
                                 at March 19,        of Common Stock     -----------------------
Name                               2003 (1)         to be Offered (1)     Number      Percentage
----                          ------------------    -----------------     ------      ----------
                                                                             
AJW Partners, LLC (2)               79,200                79,200            0              0%
AJW Offshore, Ltd. (3)                                                      0              0%
AJW Qualified Partners, LLC                                                 0              0%
  (4)

Xmark Fund, L.P. (5)             1,139,759               903,360            0              0%
                                                                            0              0%
Xmark Fund, Ltd. (6)             3,397,725             2,620,839
SDS Merchant Fund, LP (7)        1,629,338               725,373            0              0%
OTATO Limited Partnership
  (8)                              182,746               182,746            0              0%
                                 6,428,768             4,511,518

---------
(1)      Beneficial ownership is determined in accordance with the rules of the
         Securities and Exchange Commission and generally includes voting or
         investment power with respect to securities. Each entity named in the
         table has sole voting and investment power, exercised by the
         individuals indicated in the following footnotes, with respect to all
         shares of stock listed as owned by such entity.

(2)      AJW Partners, LLC is a private investment fund that is owned by its
         investors and managed by SMS Group, LLC. SMS Group, LLC, of which Corey
         S. Ribotsky is the fund manager, has voting and investment control over
         the shares owned by AJW Partners, LLC. The number of shares listed for
         AJW Partners, LLC represents shares issuable upon conversion of the
         warrant issued to AJW Partners, LLC in connection with the Company's
         repurchase of its 10% debentures.

(3)      AJW Offshore, Ltd. (formerly AJW/New Millennium Offshore, Ltd.) is a
         private investment fund that is managed by First Street Manager II,
         LLC. First Street Manager II, LLC, of which Corey S. Ribotsky is the
         fund manager, has voting and investment control over the shares owned
         by AJW Offshore, Ltd.

(4)      AJW Qualified Partners, LLC (formerly Pegasus Capital Partners, LLC) is
         a private investment fund that is owned by its investors and managed by
         AJW Manager, LLC, of which Corey S. Ribotsky and Lloyd A. Groveman are
         the fund managers. AJW Manager, LLC has voting and investment control
         over the shares owned by AJW Qualified Partners, LLC.


                                       -19-



(5)      Xmark Fund, L.P., a Delaware limited partnership, is a private
         investment fund that is owned by its investors and managed by its
         general partner, Brown Simpson Capital, L.L.C., a Delaware limited
         liability company. Brown Simpson Capital, L.L.C., of which Mitchell D.
         Kaye is the managing member, has voting and investment control over the
         shares owned by Xmark Fund, L.P. The number of shares beneficially
         owned by Xmark Fund, L.P. represents 569,325 shares issuable upon
         exercise of its warrant, 334,035 shares issuable upon conversion of its
         8% debentures (7,500 of which are issuable upon conversion of its
         Amended and Restated 8% debentures, which shares were not included on
         the previous registration statement and prospectus, as supplemented),
         and 236,399 shares issuable upon conversion of the Amended and Restated
         8% Secured Convertible Debentures (which shares are registered for
         resale pursuant to the effective registration statement (Registration
         No. 33-96739)).

(6)      Xmark Fund, Ltd., a Cayman Islands corporation, is a private investment
         fund that is owned by its investors and managed by Brown Simpson Asset
         Management, LLC, a Delaware limited liability company. Brown Simpson
         Asset Management, LLC, of which Mitchell D. Kaye is the managing
         member, has voting and investment control over the shares owned by
         Xmark Fund, Ltd. The number of shares beneficially owned by Xmark Fund,
         Ltd. represents 1,680,675 shares issuable upon exercise of its warrant,
         940,164 shares issuable upon conversion of its 8% debentures (24,649 of
         which are issuable upon conversion of its Amended and Restated 8%
         debentures, which shares were not included on the previous registration
         statement and prospectus, as supplemented), and 776,886 shares issuable
         upon conversion of the Amended and Restated 8% Secured Convertible
         Debentures (which shares are registered for resale pursuant to the
         effective registration statement (Registration No. 33-96739)).

(7)      SDS Merchant Fund, L.P. is a limited partnership of which SDS Capital
         Partners, LLC is the general partner. Steve Darby is the managing
         member of SDS Capital Partners, LLC, and exercises voting and
         investment control over the shares owned by SDS Merchant Fund, L.P. The
         number of shares beneficially owned by SDS Merchant Fund, LP represents
         682,500 shares issuable upon exercise of its warrant, 42,873 shares
         issuable upon exercise of its Amended and Restated 8% debenture (which
         shares were not included on the previous registration statement and
         prospectus, as supplemented), and 903,965 shares issuable upon
         conversion of the Amended and Restated 8% Secured Convertible
         Debentures (which shares are registered for resale pursuant to the
         effective registration statement (Registration Statement No.
         33-96739)).

(8)      OTATO Limited Partnership is a limited partnership for which OTA Grand
         Cayman, Inc., a Delaware corporation, is the general partner. By reason
         of such relationship, OTA Grand Cayman, Inc. may be deemed to share
         voting the dispositive power over the shares of common stock
         beneficially owned by OTATO Limited Partnership. As of August 1, 2002,
         Messrs. Frederick Berdon and Paul Masters, registered representatives
         of a registered broker-dealer at which OTATO Limited Partnership
         maintains a brokerage account, have discretionary authority to trade
         the shares included in the table. By reason of such discretionary
         authority, these individuals may be deemed to share dispositive power
         over the shares of stock beneficially owned by OTATO Limited
         Partnership. The number of


                                       -20-



         shares listed for OTATO Limited Partnership reflect shares issued to
         OTATO upon its conversion of the 10% debentures prior to the Company's
         repurchase of such debentures, which shares were not previously covered
         by the original registration statement and prospectus, as supplemented.

               CERTAIN INFORMATION ABOUT THE SELLING SHAREHOLDERS

         The number of shares set forth in the table for the selling
shareholders represents a good faith estimate of the number of shares of common
stock to be offered by the selling shareholders, based on the conversion price
of $.50 per share and the warrant exercise price of $.55 per share. In addition,
the actual number of shares of common stock offered in this prospectus, and
included in the registration statement of which this prospectus is a part,
includes such additional number of shares of common stock as may be issued or
issuable upon conversion of the debentures or exercise of the warrants by reason
of any stock split, stock dividend or similar transaction involving the common
stock, in accordance with Rule 416 under the Securities Act of 1933, as amended.

         Under the terms of the debentures, the debentures are convertible by
any holder only to the extent that the number of shares of common stock issuable
pursuant to such securities, together with the number of shares of common stock
owned by such holder and its affiliates (but not including shares of common
stock underlying unconverted shares of debentures) would not exceed 9.99% of the
then outstanding common stock as determined in accordance with Section 13(d) of
the Exchange Act. Each holder may, upon providing us with 61 days' written
notice, waive this 9.99% cap on conversions.

                              PLAN OF DISTRIBUTION

         We are registering the resale of certain shares of common stock into
which the debentures are convertible on behalf of the selling shareholders. The
selling shareholders may offer and resell such shares from time to time, either
in increments or in a single transaction. They may also decide not to sell all
the shares they are allowed to resell under this prospectus. The selling
shareholders will act independently of us in making decisions with respect to
the timing, manner and size of each sale.

Donees; Pledgees and Transferees

         The term "selling shareholder" includes donees, i.e., persons who
receive shares from the selling shareholders after the date of this prospectus
by gift. The term also includes pledgees, i.e., persons who upon contractual
default by the selling shareholders may seize shares which the selling
shareholders pledged to such person, and other transferees or
successors-in-interest.

Types of Sale Transactions

         The selling shareholders may sell the shares in one or more types of
transactions (which may include block transactions):


                                       -21-



         o        on the Nasdaq SmallCap Market or any national securities
                  exchange or other U.S. inter-dealer system of a registered
                  national securities association on which the common stock may
                  be listed or quoted at the time of sale;
         o        in the over-the-counter market;
         o        in negotiated transactions;
         o        through option transactions, whether the options are listed on
                  an options exchange or otherwise;
         o        through settlement of short sales; or
         o        any combination of such methods of sale.

         The selling shareholders may enter into hedging transactions with third
parties, which may in turn engage in short sales of the common stock into which
the debentures and warrants are convertible or exercisable in the course of
hedging the position they assume. The selling shareholders may also enter into
short positions or other derivative transactions relating to the common stock
into which the debentures and warrants are convertible or exercisable, or
interests in the common stock, and deliver the common stock, or interests in the
common stock, to close out their short or other positions or otherwise settle
short sales or other transactions, or loan or pledge the common stock into which
the debentures and warrants are convertible or exercisable, or interests in the
common stock, to third parties that in turn may dispose of these securities.

         The shares may be sold at market prices prevailing at the time of sale,
or at negotiated prices. Such transactions may or may not involve underwriters,
brokers or dealers. The selling shareholders have informed us that they have not
entered into any agreements, understandings or arrangements with any
underwriters or broker-dealers regarding the sale of the shares. They have also
informed us that no one is acting as underwriter or coordinating broker in
connection with the proposed sale of shares. The selling shareholders shall have
the sole and absolute discretion not to accept any purchase offer or make any
sale of shares if they deem the purchase price to be unsatisfactory at any
particular time.

Costs and Commissions

         We will not receive any proceeds from the sale of the stock by the
selling shareholders and will bear all costs, fees and expenses incident to our
obligation to register the shares of common stock issuable upon conversion of
the debentures and exercise of the warrants under the terms of the registration
rights agreement. The selling shareholders will pay all brokerage commissions
and similar selling expenses, if any, attributable to the sale of the shares.

Sales to or through Underwriters and Broker-Dealers

         The selling shareholders may conduct such transactions either by
selling shares directly to purchasers, or by selling shares to, or through
underwriters or broker-dealers. Such underwriters or broker-dealers may act
either as an agent of the selling shareholders, or as a principal for their own
account. Such underwriters or broker-dealers may receive compensation in the
form of discounts, concessions, or commissions from the selling shareholders
and/or the purchasers of the shares. This compensation might also exceed
customary commissions.


                                       -22-



Deemed Underwriting Compensation

         The selling shareholders and any third parties that act in connection
with the sale of shares may be deemed to be "underwriters" within the meaning of
Section 2(a)(11) of the Securities Act. Any discounts, commissions, concessions
or profits they earn on the disposition of the shares of common stock may be
deemed to be underwriting discounts or commissions under the Securities Act. The
selling shareholders have purchased the shares of our common stock in the
ordinary course of his business, and at the time the selling shareholders
purchased the shares of common stock, they were not a party to any agreement or
other understanding to distribute the shares, directly or indirectly.

Indemnification

         We have agreed to indemnify the selling shareholders against certain
liabilities, including liabilities arising under the Securities Act or to
contribute to payments the selling shareholders may be required to make in
respect of such liabilities. The selling shareholders may agree to indemnify any
underwriter, agent or broker-dealer that participates in transactions involving
sales of shares against certain liabilities, including liabilities under the
Securities Act.

Prospectus Delivery Requirements

         Because they may be deemed to be underwriters, the selling shareholders
must deliver this prospectus and any supplements to this prospectus in the
manner required by the Securities Act. This might include delivery through the
facilities of the Nasdaq SmallCap Market in accordance with Rule 153 of the
Securities Act. In addition, the selling shareholders' sales in the market may
be subject to the antimanipulative provisions of Regulation M under the
Securities Exchange Act of 1934, as amended, or the Exchange Act. These
provisions may restrict certain activities of, and limit the timing of purchases
and sales of any of the shares by, the selling shareholders or any other such
person. Furthermore, under Regulation M, persons engaged in a distribution of
securities are prohibited form simultaneously engaging in market making and
certain other activities with respect to such securities for a specified period
of time prior to the commencement of such distributions, subject to specified
exceptions or exemptions. Such limitations may affect the marketability of the
shares.

State Requirements

         Some states require that any shares sold in that state may only be sold
through registered or licensed brokers or dealers. In addition, some states
require that the shares have been registered or qualified for sale in that
state, or that an exemption exists from the registration or qualification
requirement and that the exemption or qualification requirements have been
complied with.


                                       -23-



Sales under Rule 144

         The selling shareholders may also resell all or a portion of their
shares in open market transactions in reliance upon Rule 144 under the
Securities Act. To do so, they must meet the criteria and conform to the
requirements of Rule 144.

Distribution Arrangements

         If a selling shareholder notifies us that any material arrangement has
been entered into with an underwriter, broker-dealer or agent for the sale of
shares through a

         o        block trade,
         o        special offering,
         o        exchange distribution or secondary distribution, or
         o        purchase by an underwriter or broker-dealer,

we will then file, if required, a supplement to this prospectus under Rule
424(b) under the Securities Act.

         The supplement will disclose the following:

         o        the name of the selling shareholder and of the participating
                  underwriter(s) or broker-dealer(s);
         o        the number of shares involved;
         o        the price at which such shares are sold;
         o        the commissions paid or discounts or concessions allowed to
                  such underwriter(s) or broker-dealer(s), where applicable;
         o        that such underwriter(s) or broker-dealer(s) did not conduct
                  any investigation to verify the information in this
                  prospectus; and
         o        any other facts material to the transaction.

                                  LEGAL MATTERS

         For the purpose of this offering, Leonard, Street and Deinard
Professional Association, Minneapolis, Minnesota is giving an opinion of the
validity of the issuance of the securities offered in this prospectus.

                                     EXPERTS

         The consolidated financial statements and schedule of Antares Pharma,
Inc. as of December 31, 2001 and 2002 and for each of the years in the
three-year period ended December 31, 2002 have been incorporated by reference
herein and in the registration statement in reliance upon the reports of KPMG
LLP, independent certified public accountants, incorporated by reference herein,
and upon the authority of said firm as experts in accounting and auditing.


                                       -24-



         The audit report covering the December 31, 2002, consolidated financial
statements contains an explanatory paragraph that states that the Company's
negative working capital, recurring losses and negative cash flows from
operations raise substantial doubt about the entity's ability to continue as a
going concern. The consolidated financial statements do not include any
adjustments that might result from the outcome of that uncertainty. The audit
report on the 2002 financial statements refers to the Company's adoption of the
cumulative deferral method of revenue recognition for licensing arrangements in
2000 and the provisions of Statement of Financial Accounting Standards No. 142,
"Goodwill and Other Intangible Assets," on January 1, 2002.

                                 INDEMNIFICATION

         Minnesota Statutes Section 302A.521 provides that a corporation shall
indemnify any person made or threatened to be made a party to a proceeding by
reason of the former or present official capacity of such person against
judgments, penalties, fines (including, without limitation, excise taxes
assessed against such person with respect to any employee benefit plan),
settlements and reasonable expenses, including attorneys' fees and
disbursements, incurred by such person in connection with the proceeding, if,
with respect to the acts or omissions of such person complained of in the
proceeding, such person

         o        has not been indemnified therefor by another organization or
                  employee benefit plan; o acted in good faith;
         o        received no improper personal benefit and Section 302A.255
                  (with respect to director conflicts of interest), if
                  applicable, has been satisfied;
         o        in the case of a criminal proceeding, had no reasonable cause
                  to believe the conduct was unlawful; and
         o        reasonably believed that the conduct was in the best interests
                  of the corporation in the case of acts or omissions in such
                  person's official capacity for the corporation or reasonably
                  believed that the conduct was not opposed to the best
                  interests of the corporation in the case of acts or omissions
                  in such person's official capacity for other affiliated
                  organizations.

         Article 7 of our Third Amended and Restated Articles of Incorporation
provides that we will indemnify directors to the fullest extent permitted by the
Minnesota Business Corporation Act as now enacted or hereafter amended.

         We also maintain an insurance policy to assist in funding
indemnification of directors and officers for certain liabilities.

         Insofar as indemnification for liabilities arising under the Securities
Act may be permitted to directors, officers or persons controlling our company
pursuant to the foregoing provisions, we have been informed that in the opinion
of the SEC such indemnification is against public policy as expressed in the
Securities Act and is therefore unenforceable.


                                       -25-



                       WHERE YOU CAN FIND MORE INFORMATION

         We file annual, quarterly and current reports, proxy statements and
other information with the SEC. Our filings are available to the public over the
internet at the SEC's web site at http://www.sec.gov. You may also read and copy
any document we file at the SEC's Public Reference Rooms in Washington, D.C.,
New York, New York, and Chicago, Illinois. A Public Reference Room is located at
450 Fifth Street, N.W., Washington, D.C. 20549. Please call the SEC at
1-800-SEC-0330 for additional information on the Public Reference Rooms.


                                       -26-



PART II

INFORMATION NOT REQUIRED IN PROSPECTUS

ITEM 14. OTHER EXPENSES OF ISSUANCE AND DISTRIBUTION

The following table sets forth the costs and expenses, other than underwriting
discounts and commissions, payable by us in connection with the sale of common
stock being registered. All amounts, except the SEC registration fee, are
estimates.

SEC Registration Fee ......................... $   191.00
Legal Fees and Expenses ......................   5,000.00
Accounting Fees and Expenses .................   5,000.00
Miscellaneous ................................     809.00

  Total ...................................... $11,000.00
                                               ==========


ITEM 15. INDEMNIFICATION OF DIRECTORS AND OFFICERS

         Minnesota Statutes Section 302A.521 provides that a corporation shall
indemnify any person made or threatened to be made a party to a proceeding by
reason of the former or present official capacity of such person against
judgments, penalties, fines (including, without limitation, excise taxes
assessed against such person with respect to any employee benefit plan),
settlements and reasonable expenses, including attorneys' fees and
disbursements, incurred by such person in connection with the proceeding, if,
with respect to the acts or omissions of such person complained of in the
proceeding, such person:

         o        has not been indemnified therefor by another organization or
                  employee benefit plan;
         o        acted in good faith;
         o        received no improper personal benefit and Section 302A.255
                  (with respect to director conflicts of interest), if
                  applicable, has been satisfied;
         o        in the case of a criminal proceeding, had no reasonable cause
                  to believe the conduct was unlawful; and
         o        reasonably believed that the conduct was in the best interests
                  of the corporation in the case of acts or omissions in such
                  person's official capacity for the corporation or reasonably
                  believed that the conduct was not opposed to the best
                  interests of the corporation in the case of acts or omissions
                  in such person's official capacity for other affiliated
                  organizations.

         Article 7 of our Third Amended and Restated Articles of Incorporation
provides that we will indemnify directors to the fullest extent permitted by the
Minnesota Business Corporation Act as now enacted or hereafter amended.

         We also maintain an insurance policy to assist in funding
indemnification of directors and officers for certain liabilities.


                                       II-1



ITEM 16. EXHIBITS

EXHIBIT
NUMBER                            DOCUMENT
-------                           --------

 4.1*          Form of our Common Stock Certificate.
 5.1           Opinion of Leonard, Street and Deinard Professional
               Association.
10.39#         Debenture and Warrant Purchase Agreement, dated January 31,
               2003, by and among Antares Pharma, Inc., XMark Fund, L.P.,
               XMark Fund, Ltd. and SDS Merchant Fund, LP.
10.40#         Debenture and Warrant Purchase Agreement, dated January 31,
               2003, by and among Antares Pharma, Inc., XMark Fund, L.P. and
               Xmark Fund, Ltd.
10.41#         Registration Rights Agreement, dated January 31, 2003, by and
               among Antares Pharma, Inc., XMark Fund, L.P., XMark Fund, Ltd.
               and SDS Merchant Fund, LP.
10.42#         Amended and Restated Security Agreement, dated January 21,
               2003, by and among Antares Pharma, Inc., XMark Fund, L.P.,
               XMark Fund, Ltd. and SDS Merchant Fund, LP.
10.43#         Form of Warrant, dated January 31, 2003.
10.44#         Form of 8% Senior Secured Convertible Debenture, dated
               January 31, 2003.
10.45#         Form of Amended and Restated 8% Senior Secured Convertible
               Debenture, dated January 31, 2003.
10.46#         Form of Promissory Note
23.1           Consent of KPMG LLP, Independent Certified Public Accountants.
23.2           Consent of Leonard, Street and Deinard Professional
               Association (included in Exhibit 5.1).
24.1           Power of Attorney (See page II-4).

-------------------------
* Previously filed as an exhibit to our Form S-3, filed with the SEC on May 31,
2001, and incorporated herein by reference.
# Previously filed as an exhibit to our Form 8-K, filed with the SEC on February
12, 2003, and incorporated herein by reference.

ITEM 17. UNDERTAKINGS

         (a)      The undersigned registrant hereby undertakes:

                  (1)      To file, during any period in which offers or sales
                           are being made, a post-effective amendment to this
                           registration statement to include any material
                           information with respect to the plan of distribution
                           not previously disclosed in the registration
                           statement or any material change to such information
                           in the registration statement.


                                       II-2



                  (2)      That, for the purpose of determining any liability
                           under the Securities Act, each such post-effective
                           amendment shall be deemed to be a new registration
                           statement relating to the securities offered therein,
                           and the offering of such securities at that time
                           shall be deemed to be the initial bona fide offering
                           thereof.

                  (3)      To remove from registration by means of a
                           post-effective amendment any of the securities being
                           registered which remain unsold at the termination of
                           the offering.

         (b) The undersigned registrant hereby undertakes that, for purposes of
determining any liability under the Securities Act, each filing of the
registrant's annual report pursuant to Section 13(a) or Section 15(d) of the
Exchange Act and, where applicable, each filing of an employee benefit plan's
annual report pursuant to Section 15(d) of the Exchange Act that is incorporated
by reference in the registration statement shall be deemed to be a new
registration statement relating to the securities offered therein, and the
offering of such securities at that time shall be deemed to be the initial bona
fide offering thereof.

         (c) Insofar as indemnification for liabilities arising under the
Securities Act may be permitted to directors, officers and controlling persons
of the registrant pursuant to the foregoing provisions, or otherwise, the
registrant has been advised that in the opinion of the SEC such indemnification
is against public policy as expressed in the Securities Act and is, therefore
unenforceable. In the event that a claim for indemnification against such
liabilities (other than the payment by the registrant of expenses incurred or
paid by a director, officer or controlling person of the registrant in the
successful defense of any action, suit or proceeding) is asserted by such
director, officer or controlling person in connection with the securities being
registered, the registrant will, unless in the opinion of its counsel the matter
has been settled by controlling precedent, submit to a court of appropriate
jurisdiction the question whether such indemnification by it is against public
policy as expressed in the Securities Act and will be governed by the final
adjudication of such issue.


                                       II-3



                                   SIGNATURES

         Pursuant to the requirements of the Securities Act of 1933, the
registrant certifies that it has reasonable grounds to believe that it meets all
of the requirements for filing on Form S-3 and has duly caused this registration
statement to be signed on its behalf by the undersigned, thereunto duly
authorized, in the City of Exton, Pennsylvania, on March 21, 2003.

                                           ANTARES PHARMA, INC.

                                           By:      /s/ Roger G. Harrison
                                              --------------------------------
                                                 Roger G. Harrison, Ph.D.
                                                 Chief Executive Officer



POWER OF ATTORNEY

         We, the undersigned officers and directors of Antares Pharma, Inc.
hereby constitute each of Roger G. Harrison, Ph.D. and Lawrence M. Christian our
true and lawful attorney-in-fact, with full power of substitution, to sign for
us and in our names in the capacities indicated below the registration statement
filed herewith and any and all amendments to said registration statement, and
generally to do all such things in our name and behalf in our capacities as
officers and directors to enable Antares Pharma, Inc. to comply with the
provisions of the Securities Act of 1933, as amended, and all requirements of
the Securities and Exchange Commission, hereby ratifying and confirming our
signatures as they may be signed by our said attorney to said registration
statement and any and all amendments thereto.

         Pursuant to the requirements of the Securities Act of 1933, this
registration statement and power of attorney has been signed below by the
following persons in the capacities and on the dates indicated.



             Signature                               Title                                       Date
             ---------                               -----                                       -----
                                                                                       
                                        Chief Executive Officer and Director                 March 21, 2003
/s/ Roger G. Harrison                   (principal executive officer)
------------------------------------
Roger G. Harrison, Ph.D.

                                        Vice President of Finance,                           March 21, 2003
/s/ Lawrence M. Christian               Chief Financial Officer and Secretary
------------------------------------    (principal financial and accounting officer)
Lawrence M. Christian



                                       II-4





                                                                                       
/s/ Jacques Gonella                     Director, Chairman of the Board                      March 21, 2003
------------------------------------
Dr. Jacques Gonella

/s/ Franklin Pass                       Director, Vice Chairman of the Board                 March 21, 2003
------------------------------------
Franklin Pass, M.D.

/s/ James Clark                         Director                                             March 21, 2003
------------------------------------
James Clark

/s/ Philippe Dro                        Director                                             March 21, 2003
------------------------------------
Dr. Philippe Dro

/s/ John Gogol                          Director                                             March 21, 2003
------------------------------------
John Gogol

/s/ Jacques Rejeange                    Director                                             March 21, 2003
------------------------------------
Jacques Rejeange



                                       II-5



EXHIBIT
NUMBER                               DOCUMENT
-------                              --------

 4.1*          Form of our Common Stock Certificate.
 5.1           Opinion of Leonard, Street and Deinard Professional
               Association.
10.39#         Debenture and Warrant Purchase Agreement, dated January 31,
               2003, by and among Antares Pharma, Inc., XMark Fund, L.P.,
               XMark Fund, Ltd. and SDS Merchant Fund, LP.
10.40#         Debenture and Warrant Purchase Agreement, dated January 31,
               2003, by and among Antares Pharma, Inc., XMark Fund, L.P. and
               Xmark Fund, Ltd.
10.41#         Registration Rights Agreement, dated January 31, 2003, by and
               among Antares Pharma, Inc., XMark Fund, L.P., XMark Fund, Ltd.
               and SDS Merchant Fund, LP.
10.42#         Amended and Restated Security Agreement, dated January 21,
               2003, by and among Antares Pharma, Inc., XMark Fund, L.P.,
               XMark Fund, Ltd. and SDS Merchant Fund, LP.
10.43#         Form of Warrant, dated January 31, 2003.
10.44#         Form of 8% Senior Secured Convertible Debenture, dated
               January 31, 2003.
10.45#         Form of Amended and Restated 8% Senior Secured Convertible
               Debenture, dated January 31, 2003.
10.46#         Form of Promissory Note
23.1           Consent of KPMG LLP, Independent Certified Public Accountants.
23.2           Consent of Leonard, Street and Deinard Professional
               Association (included in Exhibit 5.1).
24.1           Power of Attorney (See page II-4).

-------------------------
* Previously filed as an exhibit to our Form S-3, filed with the SEC on May 31,
2001, and incorporated herein by reference.
# Previously filed as an exhibit to our Form 8-K, filed with the SEC on February
12, 2003, and incorporated herein by reference.