SECURITIES AND EXCHANGE COMMISSION

                             Washington, D.C. 20549

                                  SCHEDULE 13G

                    Under the Securities Exchange Act of 1934
                                (AMENDMENT NO. 3)

                       Take-Two Interactive Software, Inc.
                       -----------------------------------
                                (Name of Issuer)


                          Common Stock, $0.01 par value
                          -----------------------------
                         (Title of Class of Securities)


                                    874054109
                                    ---------
                                 (CUSIP Number)


                                  June 21, 2006
                                  -------------

             (Date of Event Which Requires Filing of this Statement)

Check the following box to designate the rule pursuant to which the Schedule is
filed:

[ ]   Rule 13d-1(b)
[X]   Rule 13d-1(c)
[ ]   Rule 13d-1(d)


*The remainder of this cover page shall be filled out for a reporting person's
initial filing on this form with respect to the subject class of securities, and
for any subsequent amendment containing information which would alter the
disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the Securities Exchange Act of
1934 ("Act") or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, see the
Notes).









CUSIP NO. 874054109

   1.    NAMES OF REPORTING PERSONS. I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS
         (ENTITIES ONLY)
         D. E. Shaw Valence Portfolios, L.L.C.
         13-4046559

   2.    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)
         (A)   [ ]
         (B)   [ ]

   3.    SEC USE ONLY

   4.    CITIZENSHIP OR PLACE OF ORGANIZATION
         Delaware

NUMBER OF                 5. SOLE VOTING POWER
SHARES
BENEFICIALLY
OWNED BY                     -0-
EACH
REPORTING
PERSON WITH
                          6. SHARED VOTING POWER
                             4,566,853

                          7. SOLE DISPOSITIVE POWER
                             -0-

                          8. SHARED DISPOSITIVE POWER
                             4,566,853

   9.    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
         4,566,853

   10.   CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES
         (SEE INSTRUCTIONS) [ ]

   11.   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
         6.3%

   12.   TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)
         OO







CUSIP NO. 874054109

   1.    NAMES OF REPORTING PERSONS. I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS
         (ENTITIES ONLY)
         D. E. Shaw & Co., L.P.
         13-3695715

   2.    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)
         (A)  [ ]
         (B)  [ ]

   3.    SEC USE ONLY

   4.    CITIZENSHIP OR PLACE OF ORGANIZATION
         Delaware

NUMBER OF                 5. SOLE VOTING POWER
SHARES
BENEFICIALLY
OWNED BY                     -0-
EACH
REPORTING
PERSON WITH
                          6. SHARED VOTING POWER
                             4,701,570

                          7. SOLE DISPOSITIVE POWER
                             -0-

                          8. SHARED DISPOSITIVE POWER
                             4,701,570

   9.    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
         4,701,570

   10.   CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES
         (SEE INSTRUCTIONS) [ ]

   11.   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
         6.5%

   12.   TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)
         IA, PN








CUSIP NO. 874054109

   1.    NAMES OF REPORTING PERSONS. I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS
         (ENTITIES ONLY)
         D. E. Shaw & Co., L.L.C.
         13-3799946

   2.    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)
         (A)  [ ]
         (B)  [ ]

   3.    SEC USE ONLY

   4.    CITIZENSHIP OR PLACE OF ORGANIZATION
         Delaware

NUMBER OF                 5. SOLE VOTING POWER
SHARES
BENEFICIALLY
OWNED BY                     -0-
EACH
REPORTING
PERSON WITH
                          6. SHARED VOTING POWER
                             134,717

                          7. SOLE DISPOSITIVE POWER
                             -0-

                          8. SHARED DISPOSITIVE POWER
                             134,717

   9.    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
         134,717

   10.   CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES
         (SEE INSTRUCTIONS)

   11.   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
         0.2%

   12.   TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)
         OO







CUSIP NO. 874054109

   1.    NAMES OF REPORTING PERSONS. I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS
         (ENTITIES ONLY)
         David E. Shaw

   2.    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)
         (A) [ ]
         (B) [ ]

   3.    SEC USE ONLY

   4.    CITIZENSHIP OR PLACE OF ORGANIZATION
         United States

NUMBER OF                 5. SOLE VOTING POWER
SHARES
BENEFICIALLY
OWNED BY                     -0-
EACH
REPORTING
PERSON WITH
                          6. SHARED VOTING POWER
                             4,701,570

                          7. SOLE DISPOSITIVE POWER
                             -0-

                          8. SHARED DISPOSITIVE POWER
                             4,701,570

   9.    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
         4,701,570

   10.   CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES
         (SEE INSTRUCTIONS) [ ]

   11.   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
         6.5%

   12.   TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)
         IN







ITEM 1.
    (A)  NAME OF ISSUER:
         Take-Two Interactive Software, Inc.

    (B)  ADDRESS OF ISSUER'S PRINCIPAL EXECUTIVE OFFICES:
         622 Broadway
         New York, NY 10012

ITEM 2.

    (a)  NAME OF PERSON FILING:
         D. E. Shaw Valence Portfolios, L.L.C.
         D. E. Shaw & Co., L.P.
         D. E. Shaw & Co., L.L.C.
         David E. Shaw

     (b) ADDRESS OF PRINCIPAL BUSINESS OFFICE OR, IF NONE, RESIDENCE:
         The business address for each reporting person is:
         120 W. 45th Street, Tower 45, 39th Floor
         New York, NY 10036

     (c) CITIZENSHIP:

         D. E. Shaw Valence Portfolios, L.L.C. is a limited liability company
         organized under the laws of the state of Delaware.
         D. E. Shaw & Co., L.P. is a limited partnership organized under the
         laws of the state of Delaware.
         D. E. Shaw & Co., L.L.C. is a limited liability company organized under
         the laws of the state of Delaware.
         David E. Shaw is a citizen of the United States of America.

     (d) TITLE OF CLASS OF SECURITIES:
         Common Stock, $0.01 par value

     (e) CUSIP NUMBER:
         874054109

ITEM 3. IF THIS STATEMENT IS FILED PURSUANT TO RULE 13D-1(B) OR 13D-2(B) OR (C),
        CHECK WHETHER THE PERSON FILING IS A:

Not applicable

ITEM 4. OWNERSHIP

As of June 28, 2006:

(a) Amount beneficially owned:

    D. E. Shaw Valence Portfolios, L.L.C.:    4,566,853 shares

                                              This is composed of (i) 4,378,303
                                              shares in the name of D. E. Shaw
                                              Valence Portfolios, L.L.C., (ii)
                                              3,400 shares in the name of
                                              D. E. Shaw Valence, L.L.C., and
                                              (iii) 185,150 shares that
                                              D. E. Shaw Valence, L.L.C. has the
                                              right to acquire through the
                                              exercise of listed call options.

    D. E. Shaw & Co., L.P.:                   4,701,570 shares

                                              This is composed of (i) 4,378,303
                                              shares in the name of D. E. Shaw
                                              Valence Portfolios, L.L.C., (ii)
                                              3,400 shares in the name of
                                              D. E. Shaw Valence, L.L.C., (iii)
                                              185,150 shares that D. E. Shaw
                                              Valence, L.L.C. has the right to
                                              acquire through the exercise of
                                              listed call options, and (iv)
                                              134,717 shares in the name of
                                              D. E. Shaw Oculus Portfolios,
                                              L.L.C.

    D. E. Shaw & Co., L.L.C.:                 134,717 shares

                                              This is composed of 134,717 shares
                                              in the name of D. E. Shaw Oculus
                                              Portfolios, L.L.C.


    David E. Shaw:                            4,701,570 shares

                                              This is composed of (i) 4,378,303
                                              shares in the name of D. E. Shaw
                                              Valence Portfolios, L.L.C., (ii)
                                              3,400 shares in the name of
                                              D. E. Shaw Valence, L.L.C., (iii)
                                              185,150 shares that D. E. Shaw
                                              Valence, L.L.C. has the right to
                                              acquire through the exercise of
                                              listed call options, and (iv)
                                              134,717 shares in the name of
                                              D. E. Shaw Oculus Portfolios,
                                              L.L.C.

(b) Percent of class:
    D. E. Shaw Valence Portfolios, L.L.C.:    6.3%
    D. E. Shaw & Co., L.P.:                   6.5%
    D. E. Shaw & Co., L.L.C.:                 0.2%
    David E. Shaw:                            6.5%

(c)  Number of shares to which the person has:
    (i) Sole power to vote or to direct the vote:
        D. E. Shaw Valence Portfolios, L.L.C.:                 -0- shares
        D. E. Shaw & Co., L.P.:                                -0- shares
        D. E. Shaw & Co., L.L.C.:                              -0- shares
        David E. Shaw:                                         -0- shares

    (ii)  Shared power to vote or to direct the vote:
          D. E. Shaw Valence Portfolios, L.L.C.:               4,566,853 shares
          D. E. Shaw & Co., L.P.:                              4,701,570 shares
          D. E. Shaw & Co., L.L.C.:                              134,717 shares
          David E. Shaw:                                       4,701,570 shares

    (iii) Sole power to dispose or to direct the
          disposition of:
          D. E. Shaw Valence Portfolios, L.L.C.:               -0- shares
          D. E. Shaw & Co., L.P.:                              -0- shares
          D. E. Shaw & Co., L.L.C.:                            -0- shares
          David E. Shaw:                                       -0- shares

    (iv) Shared power to dispose or to direct the
         disposition of:
         D. E. Shaw Valence Portfolios, L.L.C.:                4,566,853 shares
         D. E. Shaw & Co., L.P.:                               4,701,570 shares
         D. E. Shaw & Co., L.L.C.:                               134,717 shares
         David E. Shaw:                                        4,701,570 shares

David E. Shaw does not own any shares directly. By virtue of David E. Shaw's
position as President and sole shareholder of D. E. Shaw & Co., Inc., which is
the general partner of D. E. Shaw & Co., L.P., which in turn is the managing
member and investment adviser of D. E. Shaw Valence Portfolios, L.L.C., the
managing member of D. E. Shaw Valence, L.L.C., and the investment adviser of
D. E. Shaw Oculus Portfolios, L.L.C.,and by virtue of David E. Shaw's position
as President and sole shareholder of D. E. Shaw & Co. II, Inc., which is the
managing member of D. E. Shaw & Co., L.L.C., which in turn is the managing
member of D. E. Shaw Oculus Portfolios, L.L.C., David E. Shaw may be deemed to
have the shared power to vote or direct the vote of,and the shared power to
dispose or direct the disposition of 4,701,570 shares as described above
constituting 6.5% of the outstanding shares and, therefore, David E. Shaw may be
deemed to be the beneficial owner of such shares. David E. Shaw disclaims
beneficial ownership of such 4,701,570 shares.

ITEM 5.        OWNERSHIP OF FIVE PERCENT OR LESS OF A CLASS

Not Applicable

ITEM 6.        OWNERSHIP OF MORE THAN FIVE PERCENT ON BEHALF OF ANOTHER PERSON

Not Applicable

ITEM 7.        IDENTIFICATION AND CLASSIFICATION OF THE SUBSIDIARY WHICH
               ACQUIRED THE SECURITY BEING REPORTED ON BY THE PARENT HOLDING
               COMPANY OR CONTROL PERSON

Not Applicable

ITEM 8.        IDENTIFICATION AND CLASSIFICATION OF MEMBERS OF THE GROUP

Not Applicable




ITEM 9.        NOTICE OF DISSOLUTION OF GROUP

Not Applicable

ITEM 10.       CERTIFICATION

By signing below, each of D. E. Shaw Valence Portfolios, L.L.C., D. E. Shaw &
Co., L.P., D. E. Shaw & Co., L.L.C., and David E. Shaw certify that, to the best
of such reporting person's knowledge and belief, the securities referred to
above were not acquired and are not held for the purpose of or with the effect
of changing or influencing the control of the issuer of the securities and were
not acquired and are not held in connection with or as a participant in any
transaction having such purposes or effect.








SIGNATURE

After reasonable inquiry and to the best of their knowledge and belief, the
undersigned certify that the information set forth in this statement is true,
complete and correct. Powers of Attorney, dated February 24, 2004, granted by
David E. Shaw in favor of Stuart Steckler, are attached hereto.

Dated: July 3, 2006

                                         D. E. Shaw Valence Portfolios, L.L.C.
                                         By: D. E. Shaw & Co., L.P., as
                                             managing member

                                             By: /s/ Stuart Steckler
                                                 -------------------
                                                 Stuart Steckler
                                                 Managing Director


                                         D. E. Shaw & Co., L.P.

                                         By: /s/ Stuart Steckler
                                             -------------------
                                             Stuart Steckler
                                             Managing Director


                                         D. E. Shaw & Co., L.L.C.

                                         By: /s/ Stuart Steckler
                                             -------------------
                                             Stuart Steckler
                                             Managing Director



                                         David E. Shaw

                                         By: /s/ Stuart Steckler
                                             -------------------
                                             Stuart Steckler
                                             Attorney-in-Fact for David E. Shaw










                                    EXHIBIT 1

                                POWER OF ATTORNEY
                               FOR CERTAIN FILINGS
                    UNDER THE SECURITIES EXCHANGE ACT OF 1934


I, David E. Shaw, hereby make, constitute and appoint each of:


         Anne Dinning,

         Julius Gaudio,

         Lou Salkind,

         Stuart Steckler, and

         Eric Wepsic,

acting individually, as my agent and attorney-in-fact, with full power of
substitution, for the purpose of, from time to time, executing in my name and/or
my capacity as President of D. E. Shaw & Co., Inc. (acting for itself or as the
general partner of D. E. Shaw & Co., L.P. and general partner or managing
member of other entities, any which in turn may be acting for itself or other
entities) all documents, certificates, instruments, statement, other filings,
and amendments to the forgoing (collectively, "documents") determined by such
person to be necessary or appropriate to comply with ownership or control-person
reporting requirements imposed by any United States or non-United States
governmental or regulatory authority, including without limitation Forms 3, 4,
5, 13D, 13F, and 13G required to be filed with the Securities and Exchange
Commission; and delivering, furnishing or filing any such documents with the
appropriate governmental or regulatory authority. Any such determination shall
be conclusively evidenced by such person's execution, delivery, furnishing,
and/or filing of the applicable document.

This power of attorney shall be valid from the date hereof and replaces the
power granted on February 5, 2001, which is hereby cancelled.

IN WITNESS HEREOF, I have executed this instrument as of the date set forth
below.

Date: February 24, 2004

DAVID E. SHAW, as President of
D. E. Shaw & Co., Inc.
/s/David E. Shaw
New York, New York






                                    EXHIBIT 2


                                POWER OF ATTORNEY
                               FOR CERTAIN FILINGS
                    UNDER THE SECURITIES EXCHANGE ACT OF 1934


I, David E. Shaw, hereby make, constitute and appoint each of:

         Anne Dinning,

         Julius Gaudio,

         Lou Salkind,

         Stuart Steckler, and

         Eric Wepsic,

acting individually, as my agent and attorney-in-fact, with full power of
substitution, for the purpose of, from time to time, executing in my name and/or
my capacity as President of D. E. Shaw & Co. II, Inc. (acting for itself and as
the managing member of D. E. Shaw & Co., L.L.C., which in turn may be acting for
itself or as the managing member of other companies) all documents,
certificates, instruments, statement, other filings and amendments to the
forgoing (collectively, "documents") determined by such person to be necessary
or appropriate to comply with ownership or control-person reporting requirements
imposed by any United States or non-United States governmental or regulatory
authority, including without limitation Forms 3, 4, 5, 13D, 13F and 13G required
to be filed with the Securities and Exchange Commission; and delivering,
furnishing or filing any such documents with the appropriate governmental or
regulatory authority. Any such determination shall be conclusively evidenced by
such person's execution and delivery, furnishing or filing of the applicable
document.

This power of attorney shall be valid from the date hereof and replaces the
power granted on February 5, 2001, which is hereby cancelled.

IN WITNESS HEREOF, I have executed this instrument as of the date set forth
below.

Date:  February 24, 2004

DAVID E. SHAW, as President of
D. E. Shaw & Co. II, Inc.
/s/David E. Shaw
New York, New York





                                    EXHIBIT 3

                             JOINT FILING AGREEMENT

In accordance with Rule 13d-1(k)(1) under the Securities Exchange Act of 1934,
as amended, each of the undersigned Reporting Persons hereby agrees to the joint
filing, along with all other such Reporting Persons, on behalf of each of them
of a statement on Schedule 13G (including amendments thereto) with respect to
the Common Stock, $0.01 par value, of Take-Two Interactive Software, Inc., and
that this Agreement be included as an Exhibit to such joint filing. This
Agreement may be executed in any number of counterparts, all of which taken
together shall constitute one and the same instrument.

IN WITNESS WHEREOF, each of the undersigned hereby executes this Agreement as of
this 3rd day of July, 2006.


                                   D. E. Shaw Valence Portfolios, L.L.C.
                                   By: D. E. Shaw & Co., L.P., as
                                       managing member

                                       By: /s/ Stuart Steckler
                                           -------------------
                                           Stuart Steckler
                                           Managing Director

                                   D. E. Shaw & Co., L.P.

                                   By: /s/ Stuart Steckler
                                       -------------------
                                       Stuart Steckler
                                       Managing Director



                                   D. E. Shaw & Co., L.L.C.

                                   By: /s/ Stuart Steckler
                                       -------------------
                                       Stuart Steckler
                                       Managing Director



                                   David E. Shaw

                                   By: /s/ Stuart Steckler
                                       -------------------
                                       Stuart Steckler
                                       Attorney-in-Fact for David E. Shaw