UNITED STATES
                      SECURITIES & EXCHANGE COMMISSION
                           Washington, D.C. 20549
                           ______________________

                               SCHEDULE 13G/A
                                (Rule 13d-102)


            INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT 
           TO RULES 13d-1(b), (c) AND (d) AND AMENDMENTS THERETO FILED 
                              PURSUANT TO 13d-2(b)


                               (Amendment No. 1)*


                               AVI Biopharma, Inc.  
                                (Name of Issuer)


                   Common Stock, par value $0.001 par share
                        (Title of Class of Securities)


                                  002346104
                                (CUSIP Number)


                                December 31, 2004
            (Date of event which requires filing of this statement)



     Check the appropriate box to designate the rule pursuant to which 
     this Schedule 13G is filed:

     [ ]  Rule 13d-1(b)
     [X]  Rule 13d-1(c)
     [ ]  Rule 13d-1(d)





                           
________________
     *The remainder of this cover page shall be filled out for a reporting 
person's initial filing on this form with respect to the subject class of 
securities, and for any subsequent amendment containing information which would 
alter the disclosures provided in a prior cover page.

     The information required in the remainder of this cover page shall not be 
deemed to be "filed" for purposes of Section 18 of the Securities Exchange Act 
of 1934 ("Act") or otherwise subject to the liabilities of that section of the 
Act but shall be subject to all other provisions of the Act (however, see the 
Notes). 







CUSIP No.  002346104
_____________________________________________________________________________

     (1)    NAMES OF REPORTING PERSONS 
            I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)
            
                             Smithfield Fiduciary LLC - not applicable
______________________________________________________________________________

     (2)    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP ** 
                                                       (a)  [X] 
                                                       (b)  [ ] 
______________________________________________________________________________

     (3)    SEC USE ONLY 
______________________________________________________________________________

     (4)    CITIZENSHIP OR PLACE OF ORGANIZATION
                            Cayman Islands, British West Indies
______________________________________________________________________________

               (5)  SOLE VOTING POWER 
                                                -0-
               _______________________________________________________________
NUMBER OF
               (6)  SHARED VOTING POWER
SHARES
                    392,781 shares of Common Stock 
BENEFICIALLY
                    Warrants to purchase shares of Common Stock (exercisable 
OWNED BY            for an aggregate of 2,790,026 shares of Common Stock).  
                    See footnote 1 in Item 4.
EACH           _______________________________________________________________

REPORTING      (7)  SOLE DISPOSITIVE POWER 
                                                -0-
PERSON WITH    _______________________________________________________________

               (8)  SHARED DISPOSITIVE POWER 
                        See Row 6 above.
______________________________________________________________________________

     (9)     AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                                            See Row 6 above.
______________________________________________________________________________

     (10)    CHECK BOX IF THE AGGREGATE AMOUNT 
             IN ROW (9) EXCLUDES CERTAIN SHARES ** 
                                                       [ ] 
______________________________________________________________________________

     (11)    PERCENT OF CLASS REPRESENTED 
             BY AMOUNT IN ROW (9)    
       
             4.99%.
______________________________________________________________________________

     (12)    TYPE OF REPORTING PERSON **
                                       OO - Limited Liability Company




______________________________________________________________________________

     (1)    NAMES OF REPORTING PERSONS 
            I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)
            
                        Highbridge International LLC - not applicable
______________________________________________________________________________

     (2)    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP ** 
                                                         (a)  [X] 
                                                         (b)  [ ] 
______________________________________________________________________________

     (3)    SEC USE ONLY 
______________________________________________________________________________

     (4)    CITIZENSHIP OR PLACE OF ORGANIZATION
                            Cayman Islands, British West Indies
______________________________________________________________________________

               (5)  SOLE VOTING POWER 
                                                -0-
               _______________________________________________________________
NUMBER OF
               (6)  SHARED VOTING POWER
SHARES
                    392,781 shares of Common Stock 
BENEFICIALLY
                    Warrants to purchase shares of Common Stock (exercisable 
OWNED BY            for an aggregate of 2,790,026 shares of Common Stock).  
                    See footnote 1 in Item 4.
EACH           _______________________________________________________________

REPORTING      (7)  SOLE DISPOSITIVE POWER 
                                                -0-
PERSON WITH    _______________________________________________________________

               (8)  SHARED DISPOSITIVE POWER 
                        See Row 6 above.
______________________________________________________________________________

     (9)     AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                                            See Row 6 above.
______________________________________________________________________________

     (10)    CHECK BOX IF THE AGGREGATE AMOUNT 
             IN ROW (9) EXCLUDES CERTAIN SHARES ** 
                                                       [ ] 
______________________________________________________________________________

     (11)    PERCENT OF CLASS REPRESENTED 
             BY AMOUNT IN ROW (9)    
       
             4.99%.
______________________________________________________________________________

     (12)    TYPE OF REPORTING PERSON **
                                       OO - Limited Liability Company




______________________________________________________________________________

     (1)    NAMES OF REPORTING PERSONS 
            I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)
            
                        Highbridge Capital Corporation - not applicable
______________________________________________________________________________
     (2)    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP ** 
                                                        (a)  [X] 
                                                        (b)  [ ] 
______________________________________________________________________________

     (3)    SEC USE ONLY 
______________________________________________________________________________

     (4)    CITIZENSHIP OR PLACE OF ORGANIZATION
                            Cayman Islands, British West Indies
______________________________________________________________________________

               (5)  SOLE VOTING POWER 
                                                -0-
               _______________________________________________________________
NUMBER OF
               (6)  SHARED VOTING POWER
SHARES
                    392,781 shares of Common Stock 
BENEFICIALLY
                    Warrants to purchase shares of Common Stock (exercisable 
OWNED BY            for an aggregate of 2,790,026 shares of Common Stock).  
                    See footnote 1 in Item 4.
EACH           _______________________________________________________________

REPORTING      (7)  SOLE DISPOSITIVE POWER 
                                                -0-
PERSON WITH    _______________________________________________________________

               (8)  SHARED DISPOSITIVE POWER 
                        See Row 6 above.
______________________________________________________________________________

     (9)     AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                                            See Row 6 above.
______________________________________________________________________________

     (10)    CHECK BOX IF THE AGGREGATE AMOUNT 
             IN ROW (9) EXCLUDES CERTAIN SHARES ** 
                                                       [ ] 
______________________________________________________________________________

     (11)    PERCENT OF CLASS REPRESENTED 
             BY AMOUNT IN ROW (9)    
       
             4.99%.
______________________________________________________________________________

     (12)    TYPE OF REPORTING PERSON **
                                       BD - Broker Dealer




______________________________________________________________________________

     (1)    NAMES OF REPORTING PERSONS 
            I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)
            
                    Highbridge Capital Management, LLC - 20-1901985
______________________________________________________________________________

     (2)    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP ** 
                                                        (a)  [X] 
                                                        (b)  [ ] 
______________________________________________________________________________

     (3)    SEC USE ONLY 
______________________________________________________________________________

     (4)    CITIZENSHIP OR PLACE OF ORGANIZATION
                            State of Delaware
______________________________________________________________________________

               (5)  SOLE VOTING POWER 
                                                -0-
               _______________________________________________________________
NUMBER OF
               (6)  SHARED VOTING POWER
SHARES
                    392,781 shares of Common Stock 
BENEFICIALLY
                    Warrants to purchase shares of Common Stock (exercisable 
OWNED BY            for an aggregate of 2,790,026 shares of Common Stock).  
                    See footnote 1 in Item 4.
EACH           _______________________________________________________________

REPORTING      (7)  SOLE DISPOSITIVE POWER 
                                                -0-
PERSON WITH    _______________________________________________________________

               (8)  SHARED DISPOSITIVE POWER 
                        See Row 6 above.
______________________________________________________________________________

     (9)     AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                                            See Row 6 above.
______________________________________________________________________________

     (10)    CHECK BOX IF THE AGGREGATE AMOUNT 
             IN ROW (9) EXCLUDES CERTAIN SHARES ** 
                                                       [ ] 
______________________________________________________________________________

     (11)    PERCENT OF CLASS REPRESENTED 
             BY AMOUNT IN ROW (9)    
       
             4.99%.
______________________________________________________________________________

     (12)    TYPE OF REPORTING PERSON **
                                       OO - Limited Liability Company




______________________________________________________________________________

     (1)    NAMES OF REPORTING PERSONS 
            I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)
            
                    Glenn Dubin
______________________________________________________________________________

     (2)    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP ** 
                                                        (a)  [X] 
                                                        (b)  [ ] 
______________________________________________________________________________

     (3)    SEC USE ONLY 
______________________________________________________________________________

     (4)    CITIZENSHIP OR PLACE OF ORGANIZATION
                            United States
______________________________________________________________________________

               (5)  SOLE VOTING POWER 
                                                -0-
               _______________________________________________________________
NUMBER OF
               (6)  SHARED VOTING POWER
SHARES
                    392,781 shares of Common Stock 
BENEFICIALLY
                    Warrants to purchase shares of Common Stock (exercisable 
OWNED BY            for an aggregate of 2,790,026 shares of Common Stock).  
                    See footnote 1 in Item 4.
EACH           _______________________________________________________________

REPORTING      (7)  SOLE DISPOSITIVE POWER 
                                                -0-
PERSON WITH    _______________________________________________________________

               (8)  SHARED DISPOSITIVE POWER 
                        See Row 6 above.
______________________________________________________________________________

     (9)     AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                                            See Row 6 above.
______________________________________________________________________________

     (10)    CHECK BOX IF THE AGGREGATE AMOUNT 
             IN ROW (9) EXCLUDES CERTAIN SHARES ** 
                                                       [ ] 
______________________________________________________________________________

     (11)    PERCENT OF CLASS REPRESENTED 
             BY AMOUNT IN ROW (9)    
       
             4.99%.
______________________________________________________________________________

     (12)    TYPE OF REPORTING PERSON **
                                       IN




______________________________________________________________________________

     (1)    NAMES OF REPORTING PERSONS 
            I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)
            
                    Henry Swieca
______________________________________________________________________________

     (2)    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP ** 
                                                        (a)  [X] 
                                                        (b)  [ ] 
______________________________________________________________________________

     (3)    SEC USE ONLY 
______________________________________________________________________________

     (4)    CITIZENSHIP OR PLACE OF ORGANIZATION
                            United States
______________________________________________________________________________

               (5)  SOLE VOTING POWER 
                                                -0-
               _______________________________________________________________
NUMBER OF
               (6)  SHARED VOTING POWER
SHARES
                    392,781 shares of Common Stock 
BENEFICIALLY
                    Warrants to purchase shares of Common Stock (exercisable 
OWNED BY            for an aggregate of 2,790,026 shares of Common Stock).  
                    See footnote 1 in Item 4.
EACH           _______________________________________________________________

REPORTING      (7)  SOLE DISPOSITIVE POWER 
                                                -0-
PERSON WITH    _______________________________________________________________

               (8)  SHARED DISPOSITIVE POWER 
                        See Row 6 above.
______________________________________________________________________________

     (9)     AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                                            See Row 6 above.
______________________________________________________________________________

     (10)    CHECK BOX IF THE AGGREGATE AMOUNT 
             IN ROW (9) EXCLUDES CERTAIN SHARES ** 
                                                       [ ] 
______________________________________________________________________________

     (11)    PERCENT OF CLASS REPRESENTED 
             BY AMOUNT IN ROW (9)    
       
             4.99%.
______________________________________________________________________________

     (12)    TYPE OF REPORTING PERSON **
                                       IN


 

Item 1.

(a)  Name of Issuer

	AVI Biopharma, Inc.

(b)  Address of Issuer's Principal Executive Offices: 

	One SW Columbia Street, Suite 1105
	Portland, Oregon  97258

Item 2(a).  Name of Person Filing
Item 2(b).  Address of Principal Business Office
Item 2(c).  Citizenship

This Schedule 13G/A is being filed on behalf of each of the following 
persons (each, a "Reporting Person"):

	Highbridge International LLC
        The Cayman Corporate Centre, 4th Floor
        27 Hospital Road
	Grand Cayman, Cayman Islands, British West Indies
	Citizenship:  Cayman Islands, British West Indies
	
	Highbridge Capital Corporation
        The Cayman Corporate Centre, 4th Floor
        27 Hospital Road
	Grand Cayman, Cayman Islands, British West Indies
	Citizenship:  Cayman Islands, British West Indies

	Highbridge Capital Management, LLC
	9 West 57th Street, 27th Floor
	New York, New York  10019
	Citizenship:  State of Delaware

        Glenn Dubin
        c/o Highbridge Capital Management, LLC
        9 West 57th Street, 27th Floor
        New York, New York 10019
        Citizenship:  United States

        Henry Swieca
        c/o Highbridge Capital Management, LLC
        9 West 57th Street, 27th Floor
        New York, New York 10019
        Citizenship:  United States


(d)  Title of Class of Securities
	Common Stock, par value $0.001 per share 

(e)  CUSIP Number	002346104


Item 3.	 If this statement is filed pursuant to Rule 13d-1(b), or 13d-2(b),
 check whether the person filing is a:


(a) [ ] Broker or dealer registered under Section 15 of the Act (15 U.S.C. 78o).
	
(b) [ ] Bank as defined in Section 3(a)(6) of the Act (15 U.S.C. 78c).

(c) [ ] Insurance company as defined in Section 3(a)(19) of the Act 
        (15 U.S.C. 78c).

(d) [ ] Investment company registered under Section 8 of the Investment
        Company Act of 1940 (15 U.S.C. 80a-8).

(e) [ ] An investment adviser in accordance with Rule 13d-1(b)(1)(ii)(E);

        
(f) [ ] An employee benefit plan or endowment fund in accordance with
        Rule 13d-1(b)(1)(ii)(F);

(g) [ ] A parent holding company or control person in accordance with 
        Rule 13d-1(b)(1)(ii)(G);

(h) [ ] A savings association as defined in Section 3(b) of the Federal
        Deposit Insurance Act (12 U.S.C. 1813);

(i) [ ] A church plan that is excluded from the definition of an investment 
        company under Section 3(c)(14) of the Investment Company Act of 1940 
        (15 U.S.C. 80a-3);

(j) [ ] Group, in accordance with Rule 13d-1(b)(1)(ii)(J).

If this statement is filed pursuant to Rule 13d-1(c), check this box. [X]



Item 4.	Ownership

(a)  Amount Beneficially Owned

     392,781 shares of Common Stock 

     Warrants to purchase shares of Common Stock (exercisable 
     for an aggregate of 2,790,026 shares of Common Stock). /1/


(b)  Percent of Class

     4.99%. /1/

(c)  Number of shares as to which such person has:
      (i) sole power to vote or to direct the vote
             0

     (ii) shared power to vote or to direct the vote
             See Item 4(a) above.

    (iii) sole power to dispose or to direct the disposition of
             0

     (iv) shared power to dispose or to direct the disposition of
             See item (a) above.


/1/  The securities reported herein include securities that the Reporting 
Persons may acquire in the future upon the future through the exercise of 
(i) warrants to purchase up to 173,334 shares of Common Stock issued by the 
Issuer on March 25, 2002 (the "March 2002 Warrants"), (ii) warrants to purchase 
up to 375,000 shares of Common Stock issued by the Issuer on May 5, 2003 (the 
"May 2003 Warrants"), (iii) warrants to purchase up to 1,332,601 shares of 
Common Stock issued by SuperGen, Inc. on June 26, 2003 (the "SuperGen 
Warrants"), (iv) warrants to purchase up to 649,351 shares of Common Stock 
issued by the Issuer on December 8, 2003 (the "December 2003 Warrants") and 
(v) warrants to purchase up to 259,740 shares of Common Stock issued by the 
Issuer on January 27, 2004 (the "January 2004 Warrants").  The expiration date 
for (i) the March 2002 Warrants is March 24, 2006, (ii) the May 2003 Warrants 
is May 5, 2008, (iii) the SuperGen Warrants is December 31, 2006, (iv) the 
December 2003 Warrants is December 8, 2008 and (v) the January 2004 Warrants 
is December 8, 2008.  The current exercise price for (i) the March 2002 
Warrants is $4.62, (ii) the May 2003 Warrants is $7.00, (iii) the SuperGen 
Warrants is $5.00, (iv) the December 2003 is $5.50 and (v) the January 2004 
is $5.50.

Pursuant to the terms of the March 2002 Warrants, the May 2003 Warrants, the 
SuperGen Warrants, the December 2003 Warrants and the January 2004 Warrants, 
the Reporting Persons cannot exercise such Warrants to the extent that such 
exercise would cause the Reporting Persons to be "beneficial owners" of more 
than 4.99% of the Common Stock within the meaning of Rule 13d-1 of the Act.  

Highbridge Capital Management, LLC is the trading manager of Highbridge 
International LLC and Highbridge Capital Corporation.  Glenn Dubin is a 
Managing Partner of Highbridge Capital Management, LLC.  Henry Swieca is a 
Managing Partner of Highbridge Capital Management, LLC.  Smithfield Fiduciary 
LLC is a wholly-owned subsidiary of Highbridge International LLC which is a 
wholly-owned subsidiary of Highbridge Capital Corporation, a broker/dealer.  
The foregoing should not be construed in and of itself as an admission by any 
Reporting Person as to beneficial ownership of shares of Common Stock owned 
by another Reporting Person.


Item 5.  Ownership of Five Percent or Less of a Class

	 If this  statement  is being filed to report the fact that as of the
         date  hereof the  Reporting  Person has ceased to be the  beneficial
         owner of more than five  percent of the class of  securities,  check
         the following [X].


Item 6.  Ownership of More than Five Percent on Behalf of Another Person.

		Inapplicable

Item 7.  Identification and Classification of the Subsidiary Which Acquired 
the Security Being Reported on By the Parent Holding Company

		See Item 2 above.

Item 8.  Identification and Classification of Members of the Group

		Inapplicable

Item 9.  Notice of Dissolution of Group

		Inapplicable

Item 10. Certification


By signing below I certify that, to the best of my knowledge and belief, 
the securities referred to above were not acquired and are not held for 
the purpose of or with the effect of changing or influencing the control 
of the issuer of the securities and were not acquired and are not held in 
connection with or as a participant in any transaction having that purpose 
of effect.


                              SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I 
certify that the information set forth in this statement is true, complete 
and correct.


Dated this 11th day of February, 2005	


SMITHFIELD FIDUCIARY LLC


By:  /s/  Howard Feitelberg
    -------------------------------------
     Howard Feitelberg, Director



Highbridge International LLC

By:  /s/  Howard Feitelberg
    -------------------------------------
     Howard Feitelberg, Director

 

Highbridge Capital Corporation

By:  /s/  Howard Feitelberg
    -------------------------------------
     Howard Feitelberg, Controller



Highbridge Capital Management, LLC

By:  /s/  Ronald S. Resnick 
    -------------------------------------
     Ronald S. Resnick, Managing Partner



/s/  Glenn Dubin 
-------------------------------------
Glenn Dubin 



/s/  Henry Swieca 
-------------------------------------
Henry Swieca




                        Exhibit Index
                        -------------

              Exhibit                  Description
              -------                  -----------

                 1               Joint Filing Agreement