Edgar Filing: Opko Health, Inc.

Ownership Submission

FORM 4

Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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3235-0287

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(Print or Type Responses)

1. Name and Address of Reporting Person ^*

HSIAO JANE PH D

2. Issuer Name and Ticker or Trading Symbol
Opko Health, Inc. [OPK]

5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)

__X__ Director	_____ 10% Owner
__X__ Officer (give title below)	_____ Other (specify below)
Vice Chairman & CTO

(Last)

(First)

(Middle)

OPKO HEALTH, INC., 4400 BISCAYNE BLVD.

3. Date of Earliest Transaction (Month/Day/Year)
01/31/2015

(Street)

MIAMI, FL 33137

4. If Amendment, Date Original Filed(Month/Day/Year)

6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person

(City)

(State)

(Zip)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned

1.Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	3. Transaction Code (Instr. 8)		4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
1.Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	Code	V	Amount	(A) or (D)	Price		6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
Common Stock	01/31/2015		M		978,860	A	$ 0.6728	22,626,655	D
Common Stock	01/31/2015		M		978,860	A	$ 0.8473	23,605,515	D
Common Stock	01/31/2015		M		978,860	A	$ 1.0466	24,584,375	D
Common Stock	01/31/2015		F		213,342 ⁽¹⁾	D	$ 11.777 ⁽²⁾	24,371,033	D
Common Stock	01/31/2015		M		81,085	A	$ 0.0019	15,571,631	I	See Footnote ⁽³⁾
Common Stock	01/31/2015		M		648,700	A	$ 0.3854 ⁽⁴⁾	16,220,331	I	See Footnote ⁽³⁾
Common Stock	01/31/2015		M		4,000,000	A	$ 0.4984	20,220,331	I	See Footnote ⁽³⁾
Common Stock	01/31/2015		M		22,124	A	$ 0.6728	20,242,455	I	See Footnote ⁽³⁾
Common Stock	01/31/2015		M		22,124	A	$ 0.8473	20,264,579	I	See Footnote ⁽³⁾
Common Stock	01/31/2015		M		22,125	A	$ 1.0466	20,286,704	I	See Footnote ⁽³⁾
Common Stock	01/31/2015		F		174,119 ⁽⁵⁾	D	$ 11.777 ⁽²⁾	20,112,585	I	See Footnote ⁽³⁾
Common Stock	01/31/2015		F		21,523 ⁽⁶⁾	D	$ 11.616 ⁽⁷⁾	20,091,062	I	See Footnote ⁽³⁾
Common Stock								4,472,581	I	See Footnote ⁽⁸⁾
Common Stock								1,000,000	I	See Footnote ⁽⁹⁾
Common Stock								1,000,000	I	See Footnote ⁽¹⁰⁾

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)

1. Title of Derivative Security
(Instr. 3)

2. Conversion or Exercise Price of Derivative Security

3. Transaction Date (Month/Day/Year)

3A. Deemed Execution Date, if any (Month/Day/Year)

4. Transaction Code
(Instr. 8)

5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4, and 5)

6. Date Exercisable and Expiration Date
(Month/Day/Year)

7. Title and Amount of Underlying Securities
(Instr. 3 and 4)

8. Price of Derivative Security
(Instr. 5)

9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 4)

10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4)

11. Nature of Indirect Beneficial Ownership
(Instr. 4)

Code

(A)

(D)

Date Exercisable

Expiration Date

Title

Amount or Number of Shares

Warrant (Right to Buy)

$ 0.6728

01/31/2015

978,860

03/27/2007

03/27/2017

Common Stock

978,860

$ 0

Warrant (Right to Buy)

$ 0.8473

01/31/2015

978,860

03/27/2007

03/27/2017

Common Stock

978,860

$ 0

Warrant (Right to Buy)

$ 1.0466

01/31/2015

978,860

03/27/2007

03/27/2017

Common Stock

978,860

$ 0

Warrant (Right to Buy)

$ 0.4984

01/31/2015

4,000,000

03/27/2007

03/27/2017

Common Stock

4,000,000

$ 0

See Footnote ⁽³⁾

Warrant (Right to Buy)

$ 0.0019

01/31/2015

81,085

03/27/2007

01/11/2017

Common Stock

81,085

$ 0

See Footnote ⁽³⁾

Warrant (Right to Buy)

$ 38.54 ⁽⁴⁾

01/31/2015

6,487

03/27/2007

01/11/2017

Common Stock

648,700

$ 0

See Footnote ⁽³⁾

Warrant (Right to Buy)

$ 0.6728

01/31/2015

22,124

03/27/2007

03/27/2017

Common Stock

22,124

$ 0

See Footnote ⁽³⁾

Warrant (Right to Buy)

$ 0.8473

01/31/2015

22,124

03/27/2007

03/27/2017

Common Stock

22,124

$ 0

See Footnote ⁽³⁾

Warrant (Right to Buy)

$ 1.0466

01/31/2015

22,125

03/27/2007

03/27/2017

Common Stock

22,125

$ 0

See Footnote ⁽³⁾

Reporting Owners

Reporting Owner Name / Address	Relationships
Reporting Owner Name / Address	Director	10% Owner	Officer	Other
HSIAO JANE PH D OPKO HEALTH, INC. 4400 BISCAYNE BLVD. MIAMI, FL 33137	X		Vice Chairman & CTO

Signatures

Adam Logal, Attorney-in-Fact		02/02/2015
^**Signature of Reporting Person		Date

Explanation of Responses:

*	If the form is filed by more than one reporting person, see Instruction 4(b)(v).
**	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1)	Represents number of shares withheld by the Company at the direction of the reporting person for the payment of exercise price. No shares of Common Stock were sold by the reporting person in connection with this transaction. The reporting person has retained the net number of shares issued upon the exercise of the warrants (3,149,922 shares).
(2)	Average closing market price of the Company's common stock on the three days prior to the transaction date.
(3)	These securities are owned directly by The Frost Group, LLC. The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of the securities for purposes of Section 16 or for any other purpose.
(4)	Each of the 6,487 warrants is exercisable into 100 shares of common stock, resulting in a total of 648,700 shares of common stock. Table II reflects the exercise price of $38.54 per warrant and Table I reflects the corresponding price of $0.3854 per share of common stock.
(5)	Represents number of shares withheld by the Company at the direction of the reporting person for the payment of exercise price. No shares of Common Stock were sold by the reporting person in connection with this transaction. The reporting person has retained the net number of shares issued upon the exercise of the option (3,973,339 shares).
(6)	Represents number of shares withheld by the Company at the direction of the reporting person for the payment of exercise price. No shares of Common Stock were sold by the reporting person in connection with this transaction. The reporting person has retained the net number of shares issued upon the exercise of the option (627,177 shares).
(7)	Average closing market price of the Company's common stock on the five days prior to the transaction date.
(8)	The securities are owned directly by Hsu Gamma Investment, L.P. Dr. Hsiao is the general partner of Hsu Gamma Investment, L.P. The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of the securities for purposes of Section 16 or for any other purpose.
(9)	The securities are held by The Chin Hsiao Family Trust A, of which Jane H. Hsiao, Ph.D. is the trustee.
(10)	The securities are held by The Chin Hsiao Family Trust B, of which Jane H. Hsiao, Ph.D. is the trustee.

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