FORM 3

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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(Print or Type Responses)

1. Name and Address of Reporting Person *   Cumbo Alexander 2. Date of Event Requiring Statement (Month/Day/Year) 09/20/2016 3. Issuer Name and Ticker or Trading Symbol Sarepta Therapeutics, Inc. [SRPT] (Last) (First) (Middle) 215 FIRST STREET, SUITE 415 4. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director _____ 10% Owner __X__ Officer (give title below) _____ Other (specify below) VP, Head of Commercial 5. If Amendment, Date Original Filed(Month/Day/Year) (Street) CAMBRIDGE, MA 02142 6. Individual or Joint/Group Filing(Check Applicable Line) _X_ Form filed by One Reporting Person ___ Form filed by More than One Reporting Person (City) (State) (Zip) Table I - Non-Derivative Securities Beneficially Owned

1.Title of Security (Instr. 4) 2. Amount of Securities Beneficially Owned (Instr. 4) 3. Ownership Form: Direct (D) or Indirect (I) (Instr. 5) 4. Nature of Indirect Beneficial Ownership (Instr. 5) Common Stock 20,293 (1) (2) D Â

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.			SEC 1473 (7-02)
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Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)

1. Title of Derivative Security (Instr. 4)	2. Date Exercisable and Expiration Date (Month/Day/Year)		3. Title and Amount of Securities Underlying Derivative Security (Instr. 4)		4. Conversion or Exercise Price of Derivative Security	5. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 5)	6. Nature of Indirect Beneficial Ownership (Instr. 5)
	Date Exercisable	Expiration Date	Title	Amount or Number of Shares
Incentive Stock Options (right to buy)	01/02/2014(3)	01/02/2023	Common Stock	12,785	$ 26.24	D	Â
Non-Qualified Stock Options (right to buy)	01/02/2014(3)	01/02/2023	Common Stock	52,215	$ 26.24	D	Â
Incentive Stock Options (right to buy)	06/04/2014(4)	06/04/2023	Common Stock	1,845	$ 34.92	D	Â
Non-Qualified Stock Options (right to buy)	06/04/2014(4)	06/04/2023	Common Stock	16,155	$ 34.92	D	Â
Incentive Stock Options (right to buy)	02/28/2015(4)	02/28/2024	Common Stock	896	$ 29.03	D	Â
Non-Qualified Stock Options (right to buy)	02/28/2015(4)	02/28/2024	Common Stock	20,604	$ 29.03	D	Â
Incentive Stock Options (right to buy)	02/27/2016(4)	02/27/2025	Common Stock	5,836	$ 13.9	D	Â
Non-Qualified Stock Options (right to buy)	02/27/2016(4)	02/27/2025	Common Stock	14,164	$ 13.9	D	Â
Incentive Stock Options (right to buy)	02/28/2017(4)	02/28/2026	Common Stock	6,161	$ 13.71	D	Â
Non-Qualified Stock Options (right to buy)	02/28/2017(4)	02/28/2026	Common Stock	13,839	$ 13.71	D	Â
Non-Qualified Stock Options (right to buy)	06/04/2014(5)	06/04/2023	Common Stock	14,400	$ 34.92	D	Â
Incentive Stock Options (right to buy)	02/28/2017(6)	02/28/2026	Common Stock	1,726	$ 13.71	D	Â
Non-Qualified Stock Options (right to buy)	02/28/2017(6)	02/28/2026	Common Stock	18,274	$ 13.71	D	Â

Reporting Owners

Reporting Owner Name / Address	Relationships
	Director	10% Owner	Officer	Other
Cumbo Alexander 215 FIRST STREET SUITE 415 CAMBRIDGE, MA 02142	Â	Â	  VP, Head of Commercial	Â

Signatures

/s/David Tyronne Howton, as Attorney-in-Fact for Alexander Cumbo		09/30/2016
**Signature of Reporting Person		Date

Explanation of Responses:

*	If the form is filed by more than one reporting person, see Instruction 5(b)(v).
**	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1)	Includes 16,875 Restricted Stock Awards vest upon the Company exceeding $80 million in total revenue reported in publicly released GAAP financials, in any fiscal quarter between grant date and June 30, 2018, with an additional 3,825 Restricted Stock Awards vesting during the same period if the total revenue reported in the publicly released GAAP financials exceeds $100 million. The Company will withhold the shares to satisfy the executive's tax obligation upon vesting.
(2)	Includes shares acquired under the Sarepta Therapeutics, Inc. 2013 Employee Stock Purchase Plan, 1600 shares were acquired at a price of $11.466 and 800 shares were acquired at a price of $11.815.
(3)	25% of the option granted vests and is exercisable on the first anniversary of the date of hire and 1/48th of the total granted option will vest and become exercisable on each monthly anniversary thereafter, such that the option will be fully vested and exercisable on the fourth anniversary of the date of hire.
(4)	25% of the option granted vests and is exercisable on the first anniversary of the date of grant and 1/48th of the total granted option will vest and become exercisable on each monthly anniversary thereafter, such that the option will be fully vested and exercisable on the fourth anniversary of the date of grant.
(5)	In the event of the achievement of certain performance milestones prior to January 1, 2017, the shares subject to the option will vest and become exercisable with respect to 1/4th of the total number of shares subject to the option on June 4, 2014 and 1/48th of the original number of shares subject to the option monthly thereafter, subject to continued service with the Issuer.
(6)	Half of the options begin vesting in the event the FDA provides marketing approval for eteplirsen as of the applicable PDUFA date and the other half of the options begin vesting in the event Sarepta files a Marketing Authorization Application with the EMEA prior to December 31, 2016. Vesting of the options allocated to the achievement of each goal is as follows: (i) 50% of the options allocated to the achieved goal vests immediately upon achievement of the performance condition (25% of the total Performance-Based Options granted) and (ii) the remaining 50% of the options allocated to the achieved goal (25% of the total Performance-Based Options granted) vests over four years with 25% of these remaining options vesting on the first year anniversary of the grant date and 1/48th of these remaining options vesting monthly thereafter.

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