Ownership Submission
FORM 4
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
HOWE LESLEY H
   2. Issuer Name and Ticker or Trading Symbol
NUVASIVE INC [NUVA] 		5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
__X__ Director _____ 10% Owner
_____ Officer (give title below) _____ Other (specify below)
(Last)
(First)
(Middle)
7475 LUSK BLVD.		 3. Date of Earliest Transaction (Month/Day/Year)
05/03/2018
(Street)

SAN DIEGO, CA 92121		 4. If Amendment, Date Original Filed(Month/Day/Year)
 6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)		 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code
(Instr. 8)		 4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)		 5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)		 6. Ownership Form: Direct (D) or Indirect (I)
(Instr. 4)		 7. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V Amount (A) or (D) Price
Common Stock 05/03/2018   M   15,247 (1) A $ 0 26,244 (2) D  

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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 3)		 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code
(Instr. 8)		 5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4, and 5)		 6. Date Exercisable and Expiration Date
(Month/Day/Year)		 7. Title and Amount of Underlying Securities
(Instr. 3 and 4)		 8. Price of Derivative Security
(Instr. 5)		 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 4)		 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4)		 11. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
RSUs $ 0 05/03/2018   M     2,833   (3)   (3) Common Stock 2,833 $ 0 0 D  
RSUs $ 0 05/03/2018   M     2,833   (4)   (4) Common Stock 2,833 $ 0 0 D  
RSUs $ 0 05/03/2018   M     3,725   (5)   (5) Common Stock 3,725 $ 0 0 D  
RSUs $ 0 05/03/2018   M     2,501   (6)   (6) Common Stock 2,501 $ 0 0 D  
RSUs $ 0 05/03/2018   M     2,822   (7)   (7) Common Stock 2,822 $ 0 0 D  
RSUs $ 0 05/03/2018   M     533   (8)   (8) Common Stock 533 $ 0 1,597 D  

Reporting Owners

Reporting Owner Name / Address Relationships
 Director  10% Owner  Officer  Other
HOWE LESLEY H
7475 LUSK BLVD.
SAN DIEGO, CA 92121		   X      

Signatures

 /s/ Nathaniel B. Sisitsky, Attorney-in-Fact for Lesley H. Howe   05/07/2018
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) On May 3, 2018, the Reporting Person retired from his position as a member of the Issuer's Board of Directors. Pursuant to deferral elections made by the Reporting Person, all shares underlying Restricted Stock Units ("RSUs") subject to such deferrals were delivered to the Reporting Person promptly following the Issuer's 2018 Annual Meeting of Stockholders on May 3, 2018, the date on which the Reporting Person retired; provided, however, that 1,597 shares remain subject to deferred delivery over the next three years.
(2) Shares directly held by the Reporting Person. The Reporting Person also holds conditional rights to receive shares pursuant to previously disclosed Issuer equity awards.
(3) This RSU award was granted to the Reporting Person on May 24, 2012 and is fully vested.
(4) This RSU award was granted to the Reporting Person on May 23, 2013 and is fully vested.
(5) This RSU award was granted to the Reporting Person on May 22, 2014 and is fully vested.
(6) This RSU award was granted to the Reporting Person on June 12, 2015 and is fully vested.
(7) This RSU award was granted to the Reporting Person on May 19, 2016 and is fully vested.
(8) This RSU award was granted to the Reporting Person on May 18, 2017 and is fully vested.

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