Ownership Submission
FORM 4
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
MADDON PAUL J
   2. Issuer Name and Ticker or Trading Symbol
PROGENICS PHARMACEUTICALS INC [PGNX] 		5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
_____ Director __X__ 10% Owner
__X__ Officer (give title below) _____ Other (specify below)
Chief Executive Officer/CSO
(Last)
(First)
(Middle)
777 OLD SAW MILL RIVER ROAD		 3. Date of Earliest Transaction (Month/Day/Year)
04/03/2006
(Street)

TARRYTOWN, NY 10591		 4. If Amendment, Date Original Filed(Month/Day/Year)
 6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)		 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code
(Instr. 8)		 4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)		 5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)		 6. Ownership Form: Direct (D) or Indirect (I)
(Instr. 4)		 7. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V Amount (A) or (D) Price
Common Stock 04/03/2006   M   1,490 (1) A $ 21.769 606,185 (2) D  
Common Stock 04/03/2006   F   1,356 D $ 25.61 604,829 D  
Common Stock 04/03/2006   M   2,500 A $ 5.33 607,329 D  
Common Stock 04/03/2006   S   2,500 (3) D $ 25.519 604,829 D  
Common Stock 04/03/2006   M   2,500 A $ 5.33 607,329 D  
Common Stock 04/03/2006   S   2,500 (3) D $ 25.578 604,829 D  
Common Stock 04/03/2006   M   2,500 A $ 5.33 607,329 D  
Common Stock 04/03/2006   S   2,500 (3) D $ 26.06 604,829 D  
Common Stock 04/03/2006   M   2,500 A $ 5.33 607,329 D  
Common Stock 04/03/2006   S   2,500 (3) D $ 26.3 604,829 D  

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 3)		 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code
(Instr. 8)		 5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4, and 5)		 6. Date Exercisable and Expiration Date
(Month/Day/Year)		 7. Title and Amount of Underlying Securities
(Instr. 3 and 4)		 8. Price of Derivative Security
(Instr. 5)		 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 4)		 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4)		 11. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
ESPP (right to buy) (4) $ 21.769 04/03/2006   M     1,490 (5) 04/03/2006 04/03/2006 Common Stock 1,490 $ 0 0 D  
ESPP (right to buy) (4) $ 26.49 04/03/2006   A   1,333 (6)   10/02/2006 10/02/2006 Common Stock 1,333 $ 0 1,333 D  
Non-Qualified Stock Option (right to buy) (7) $ 5.33 04/03/2006   M     2,500 12/15/1997 12/16/2007 Common Stock 2,500 $ 0 67,274 D  
Non-Qualified Stock Option (right to buy) (7) $ 5.33 04/03/2006   M     2,500 12/15/1997 12/16/2007 Common Stock 2,500 $ 0 64,774 D  
Non-Qualified Stock Option (right to buy) (7) $ 5.33 04/03/2006   M     2,500 12/15/1997 12/16/2007 Common Stock 2,500 $ 0 62,274 D  
Non-Qualified Stock Option (right to buy) (7) $ 5.33 04/03/2006   M     2,500 12/15/1997 12/16/2007 Common Stock 2,500 $ 0 59,774 D  

Reporting Owners

Reporting Owner Name / Address Relationships
 Director  10% Owner  Officer  Other
MADDON PAUL J
777 OLD SAW MILL RIVER ROAD
TARRYTOWN, NY 10591		     X   Chief Executive Officer/CSO  

Signatures

 Paul J. Maddon   04/05/2006
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) Acquired upon the complete exercise of a grant under the Non-Qualified Employee Stock Purchase Plan, which grant was previously reported at the start of a six month option term, to acquire common stock up to an option amount which is 25% of the optionee's quarterly salary less $6,250, at a purchase price equal to the lower of 100% of the market value on the date of grant or 85% of the market value on the date of exercise.
(2) Includes shares of common stock acquired from the non-reportable exercise under a Qualified Employee Stock Purchase Plan.
(3) Sale under a 10b5-1 Plan, which was established in accordance with the policies and procedures of the Issuer, approved by its Board of Directors
(4) Granted under the Company's Non-Qualified Employeee Stock Purchase Plan.
(5) The option was granted on the first day of the option term and previously reported as a right to purchase shares of the Company's common stock at an exercise price equal to the market value on the date of grant. In accordance with the Non-Qualified Employee Stock Purchase Plan, the option is ultimately exercisable for an exercise price which is the lower of 100% of the market value on the grant date or 85% of the market value on the day prior to the exercise date. The number of shares exercised is based on the option amount divided by the lower of 100% of the market value on the grant date or 85% of the market value on the day prior to the exercise date.
(6) The option will be exercisable for that number of shares equal to the option amount (25% of the optionee's quarterly salary less $6,250) divided by the lesser of the market value of the common stock on the grant date or 85% of the market value on the day prior to the exercise date.
(7) The Reporting Person is exercising options under this grant in pre-established increments under and in accordance with provisions of a previously established Plan of Sale under Rule 10b5-1, which was established in accordance with the policies and procedures of the Issuer, approved by its Board of Directors.

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