UNITED STATES
                   SECURITIES AND EXCHANGE COMMISSION
                         Washington, D.C.  20549

                              SCHEDULE 13G

                Under the Securities Exchange Act of 1934
                           (Amendment No. 1)

                       Neurocrine Biosciences, Inc.
                            (Name of Issuer)

                             Common Stock
                      (Title of Class of Securities)

                                64125C109
                              (CUSIP Number)



Check the appropriate box to designate the rule pursuant to which this
Schedule is filed:

     [X] Rule 13d-1(b)
     [ ] Rule 13d-1(c)
     [ ] Rule 13d-1(d)

*The remainder of this cover page shall be filled out for a reporting
person's initial filing on this form with respect to the subject class
of securities, and for any subsequent amendment containing information
which would alter the disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not
be deemed to be "filed" for the purpose of Section 18 of the Securities
Exchange Act of 1934 ("Act") or otherwise subject to the liabilities of
that section of the Act but shall be subject to all other provisions of
the Act (however, see the Notes).


                                   13G

CUSIP NO.  64125C109


1)        NAME OF REPORTING PERSON
          S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

            Wells Fargo & Company
            Tax Identification No. 41-0449260

2)        CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*    (a)  [ ]
                                                               (b)  [ ]
3)        SEC USE ONLY

4)        CITIZENSHIP OR PLACE OF ORGANIZATION

            Delaware

NUMBER OF          (5)  SOLE VOTING POWER
SHARES                    642,729
BENEFICIALLY       (6)  SHARED VOTING POWER
OWNED BY                  0
EACH               (7)  SOLE DISPOSITIVE POWER
REPORTING                 357,834
PERSON             (8)  SHARED DISPOSITIVE POWER
WITH                      872,600

9)         AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
             1,236,314

10)        CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
           SHARES

11)        PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
             Less than 5%

12)        TYPE OF REPORTING PERSON

             HC


                              UNITED STATES
                   SECURITIES AND EXCHANGE COMMISSION
                         Washington, D.C.  20549

                             SCHEDULE 13G
               Under the Securities Exchange Act of 1934
                           (Amendment No. 1)

DISCLAIMER:  Information in this Schedule 13G is provided solely for
the purpose of complying with Sections 13(d) and 13(g) of the Act and
regulations promulgated thereunder, and is not to be construed as an
admission that Wells Fargo & Company or any of its subsidiaries is the
beneficial owner of the securities covered by this Schedule 13G for any
purpose whatsoever.

Item 1(a)  Name of Issuer:

           Neurocrine Biosciences, Inc.

Item 1(b)  Address of Issuer's Principal Executive Offices:

           10555 Science Center Drive
           San Diego, CA  92121

Item 2(a)  Name of Person Filing:

           Wells Fargo & Company

Item 2(b)  Address of Principal Business Office:

           Wells Fargo & Company
           420 Montgomery Street
           San Francisco, CA  94104

Item 2(c)  Citizenship:

           Delaware

Item 2(d)  Title of Class of Securities:

           Common Stock

Item 2(e)  CUSIP Number:

           64125C109

Item 3     The person filing is a:

           Parent Holding Company in accordance with 240.13d-
           1(b)(1)(ii)(G)

Item 4     Ownership:

           See Items 5-11 of each cover page.

Item 5     Ownership of Five Percent or Less of a Class:

           If this statement is being filed to report the fact that as
           of the date hereof the reporting persons have ceased to be
           beneficial owners of more than five percent of the class of
           securities, check the following [ ].

Item 6     Ownership of More than Five Percent on Behalf of Another
           Person:

           Not applicable.

Item 7     Identification and Classification of the Subsidiary Which
           Acquired the Security Being Reported on by the Parent
           Holding Company:

           See Attachment A.

Item 8     Identification and Classification of Members of the Group:

           Not applicable.

Item 9     Notice of Dissolution of Group:

           Not applicable.

Item 10    Certification:

           By signing below, I certify that, to the best of my
           knowledge and belief, the securities referred to above were
           acquired in the ordinary course of business and were not
           acquired for the purpose of and do not have the effect of
           changing or influencing the control of the issuer of such
           securities and were not acquired in connection with or as a
           participant in any transaction having such purposes or
           effect.

Signature.

After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true,
complete, and correct.

Date:  April 16, 2001

WELLS FARGO & COMPANY



By:  /s/ Laurel A. Holschuh
         Laurel A. Holschuh, Senior Vice President
          and Secretary


                              ATTACHMENT A

The Schedule 13G to which this attachment is appended is filed by Wells
Fargo & Company on behalf of the following subsidiaries:

     Peregrine Capital Management, Inc. (1)
     Wells Capital Management, Inc. (1)
     Wells Fargo Bank, N.A. (2)
     Wells Fargo Bank Minnesota, N.A. (2)


__________________

(1)  Classified  as a registered investment advisor in accordance with
     Regulation 13d-1(b)(1)(ii)(E).
(2)  Classified as a bank in accordance with Regulation
     13d-1(b)(1)(ii)(B).