FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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(Print or Type Responses)

1. Name and Address of Reporting Person * DOVEY BRIAN H   2. Issuer Name and Ticker or Trading Symbol ZOGENIX, INC. [ZGNX] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director __X__ 10% Owner _____ Officer (give title below) _____ Other (specify below) (Last) (First) (Middle) C/O DOMAIN ASSOCIATES, LLC, ONE PALMER SQUARE 3. Date of Earliest Transaction (Month/Day/Year) 11/29/2010 (Street) PRINCETON, NJ 08542 4. If Amendment, Date Original Filed(Month/Day/Year) 6. Individual or Joint/Group Filing(Check Applicable Line) _X_ Form filed by One Reporting Person ___ Form filed by More than One Reporting Person (City) (State) (Zip) Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned

1.Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Common Stock 11/29/2010   C   2,064,781 A (1) 2,064,781 I By Domain Partners VII, L.P. (3) Common Stock 11/29/2010   C   1,232,861 A (1) 3,297,642 I By Domain Partners VII, L.P. (3) Common Stock 11/29/2010   C   873,800 A (2) 4,171,442 I By Domain Partners VII, L.P. (3) Common Stock 11/29/2010   P   2,310,589 A $ 4 6,482,031 I By Domain Partners VII, L.P. (3) Common Stock 11/29/2010   C   35,215 A (1) 35,215 I By DP VII Associates, L.P. (3) Common Stock 11/29/2010   C   21,027 A (1) 56,242 I By DP VII Associates, L.P. (3) Common Stock 11/29/2010   C   14,903 A (2) 71,145 I By DP VII Associates, L.P. (3) Common Stock 11/29/2010   P   39,410 A $ 4 110,555 I By DP VII Associates, L.P. (3) Common Stock 11/29/2010   C   9,894 A (1) 9,894 I By Domain Partners VI, L.P. (3) Common Stock 11/29/2010   C   106 A (1) 106 I By DP VI Associates, L.P. (3)

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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)

1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Underlying Securities (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares
Series A-1 Preferred Stock	(1)	11/29/2010		C			2,064,781	(1)	(1)	Common Stock	2,064,781	$ 0	0	I	By Domain Partners VII, L.P. (3)
Series B Preferred Stock	(1)	11/29/2010		C			1,232,861	(1)	(1)	Common Stock	1,232,861	$ 0	0	I	By Domain Partners VII, L.P. (3)
Convertible Promissory Notes	(2)	11/29/2010		C			873,800	(1)	(1)	Common Stock	873,800	$ 0	0	I	By Domain Partners VII, L.P. (3)
Series A-1 Preferred Stock	(1)	11/29/2010		C			35,215	(1)	(1)	Common Stock	35,215	$ 0	0	I	By DP VII Associates, L.P. (3)
Series B Preferred Stock	(1)	11/29/2010		C			21,027	(1)	(1)	Common Stock	21,027	$ 0	0	I	By DP VII Associates, L.P. (3)
Convertible Promissory Notes	(2)	11/29/2010		C			14,903	(1)	(1)	Common Stock	14,903	$ 0	0	I	By DP VII Associates, L.P. (3)
Series A-1 Preferred Stock	(1)	11/29/2010		C			9,894	(1)	(1)	Common Stock	9,894	$ 0	0	I	By Domain Partners VI, L.P. (3)
Series A-1 Preferred Stock	(1)	11/29/2010		C			106	(1)	(1)	Common Stock	106	$ 0	0	I	By DP VI Associates, L.P. (3)

Reporting Owners

Reporting Owner Name / Address	Relationships
	Director	10% Owner	Officer	Other
DOVEY BRIAN H C/O DOMAIN ASSOCIATES, LLC ONE PALMER SQUARE PRINCETON, NJ 08542		X

Signatures

/s/Kathleen K. Schoemaker, Attorney-in-Fact		12/01/2010
**Signature of Reporting Person		Date

Explanation of Responses:

*	If the form is filed by more than one reporting person, see Instruction 4(b)(v).
**	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1)	All outstanding shares of the Issuer's preferred stock were automatically converted into Common Stock upon the closing of the Issuer's initial public offering (the "IPO"), for no additional consideration.
(2)	All Convertible Promissory Notes, plus interest accrued thereon through the closing of the IPO, automatically converted into Common Stock upon the closing of the IPO, based on the IPO price of $4.00 per share.
(3)	The Reporting Person also indirectly beneficially owns 11,000 shares of Common Stock held by Domain Associates, LLC. The Reporting Person is a Managing Member of (i) One Palmer Square Associates VII, LLC, which is the sole general partner of Domain Partners VII, L.P. and DP VII Associates, L.P., (ii) One Palmer Square Associates VI, LLC, which is the sole general partner of Domain Partners VI, L.P. and DP VI Associates, L.P., and (iii) Domain Associates, LLC. Pursuant to Instruction (4)(b)(iv) of Form 4, the Reporting Person has elected to report as indirectly beneficially owned the entire number of securities beneficially owned by each such entity. The Reporting Person disclaims beneficial ownership of any securities, and any proceeds thereof, that exceed his or her pecuniary interest therein and/or that are not actually distributed to him or her.

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