UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549
                                  SCHEDULE 13D
                   Under the Securities Exchange Act of 1934
                                (Amendment No. 1)*


                              ANTARES PHARMA, INC.
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                                (Name of Issuer)

                    Common Stock, par value $0.01 per share
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                         (Title of Class of Securities)

                                   036642106
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                                 (CUSIP Number)

Mitchell D. Kaye, Manager                           with a copy to:
Xmark Asset Management, LLC                         Steven E. Siesser, Esq.
152 West 57th Street                                Lowenstein Sandler PC
21st Floor                                          65 Livingston Avenue
New York, New York  10019                           Roseland, New Jersey  07068
(212) 247-8200                                      (973) 597-2506
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                 (Name, Address and Telephone Number of Person
                Authorized to Receive Notices and Communications)

                                December 31, 2003
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             (Date of Event which Requires Filing of this Statement)


If the filing person has previously  filed a statement on Schedule l3G to report
the  acquisition  that is the subject of this  Schedule  13D, and is filing this
schedule  because of Sections 240.13d-1(e),  240.13d-1(f) or 240.13d-1(g), check
the following box. [ ]

Note:  Schedules  filed in paper format shall include a signed original and five
copies of the schedule, including all exhibits.  See Section 240.13d-7 for other
parties to whom copies are to be sent.

* The remainder of this cover page shall be filled out for a reporting  person's
initial filing on this form with respect to the subject class of securities, and
for  any  subsequent   amendment   containing   information  which  would  alter
disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the  Securities  Exchange  Act of
1934 ("Act") or otherwise  subject to the liabilities of that section of the Act
but  shall be  subject  to all other  provisions  of the Act  (however,  see the
Notes).




Cusip No.         036642106
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1.  Names of Reporting Persons.  I.R.S. Identification Nos. of above persons
   (entities only):
                       Xmark Asset Management, LLC
                               13-3954392
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2.  Check the Appropriate Box if a Member of a Group (See Instructions):
         (a)                  Not
         (b)               Applicable
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3.  SEC Use Only
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4.  Source of Funds (See Instructions):  WC
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5.  Check  if  Disclosure of  Legal Proceedings  Is Required  Pursuant  to Items
    2(d) or 2(e):                 Not Applicable
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6.  Citizenship or Place of Organization:   New York, United States

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    Number of                      7. Sole Voting Power:                  *
                                     -------------------------------------------
    Shares Beneficially            8. Shared Voting Power:                *
                                     -------------------------------------------
    Owned by
    Each Reporting                 9. Sole Dispositive Power:             *
                                      ------------------------------------------
    Person With                    10. Shared Dispositive Power:          *
                                      ------------------------------------------
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11. Aggregate Amount Beneficially Owned by Each Reporting Person:   6,394,774*
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12. Check if  the  Aggregate  Amount in  Row (11) Excludes  Certain  Shares (See
    Instructions):               Not Applicable

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13. Percent of Class Represented by Amount in Row (11):   25.7%*
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14. Type of Reporting Person (See Instructions):   IA

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*  Xmark Fund, L.P., a Delaware limited partnership ("Xmark LP"), is  the holder
of: (i) 392,183 shares (the "Xmark LP Shares") of Common Stock,  par value $0.01
per share (the "Common Stock"), of Antares Pharma, Inc., a Minnesota corporation
(the "Company");  (ii) warrants (the "Initial Xmark LP Warrants") which, subject
to certain exercise restrictions contained therein, entitle Xmark LP to purchase
up to an  aggregate of 569,325  shares of Common  Stock at an exercise  price of
$0.28 per share (the "Initial Xmark LP Warrant Shares"), which exercise price is
subject to  adjustment  as set forth in the  Initial  Xmark LP  Warrants;  (iii)
warrants  (the "2003  Xmark LP  Warrants")  which,  subject to certain  exercise
restrictions contained therein,  entitle Xmark LP to purchase an aggregate of up
to 238,125  shares of Common Stock at an exercise  price of $1.25 per share (the
"2003 Xmark LP Warrant  Shares"),  which exercise price is subject to adjustment
as set forth in the 2003 Xmark LP Warrants;  and (iv) 44,927  shares (the "Xmark
LP Series D Preferred  Shares") of the Company's Series D Convertible  Preferred
Stock,  par value $0.01 per share (the "Series D Preferred  Stock").  Subject to
certain restrictions  contained in the Company's  Certificate of Designations of
Series D Preferred  Stock (the  "Certificate  of  Designations"),  each Xmark LP
Series D Preferred Share is convertible  into ten shares of Common Stock, for an
aggregate of 449,270 shares of Common Stock (the "Xmark LP Conversion Shares").

Xmark Fund, Ltd., a Cayman Islands exempted company ("Xmark Ltd"), is the holder
of: (i) 904,315  shares of Common  Stock (the "Xmark Ltd  Shares,"  and together
with the Xmark LP Shares,  the "Shares");  (ii) warrants (the "Initial Xmark Ltd
Warrants,"  and  together  with the  Initial  Xmark LP  Warrants,  the  "Initial
Warrants") which,  subject to certain exercise  restrictions  contained therein,
entitle  Xmark Ltd to purchase an aggregate of up to 1,680,675  shares of Common
Stock at an exercise  price of $0.28 per share (the  "Initial  Xmark Ltd Warrant
Shares," and,  together with the Initial Xmark LP Warrant  Shares,  the "Initial



Warrant Shares"),  which exercise price is subject to adjustment as set forth in
the Initial  Xmark Ltd Warrants;  (iii)  warrants (the "2003 Xmark Ltd Warrant,"
and  together  with the 2003  Xmark LP Warrant  and the  Initial  Warrants,  the
"Warrants") which, subject to certain exercise  restrictions  contained therein,
entitle  Xmark Ltd to purchase an  aggregate  of up to 511,875  shares of Common
Stock at an  exercise  price of $1.25 per share  (the  "2003  Xmark Ltd  Warrant
Shares," and together the 2003 Xmark LP Warrant  Shares and the Initial  Warrant
Shares, the "Warrant Shares"),  which exercise price is subject to adjustment as
set forth in the 2003 Xmark Ltd  Warrant;  and (iv)  135,234  shares of Series D
Preferred Stock (the "Xmark Ltd Series D Preferred  Shares",  and, together with
the Xmark LP Series D Preferred  Shares,  the  "Preferred  Shares").  Subject to
certain  restrictions  contained in the Certificate of Designations,  each Xmark
Ltd Series D Preferred Share is convertible into ten shares of Common Stock, for
an  aggregate of  1,352,340  shares of Common  Stock (the "Xmark Ltd  Conversion
Shares,"  and,  together with the Xmark LP Conversion  Shares,  the  "Conversion
Shares").

Each of the Warrants,  and the Certificate of Designations,  provides that in no
event shall such Warrant,  or such  Preferred  Shares,  be  exercisable  for, or
convertible  into,  shares of Common  Stock to the extent  that the  issuance of
Warrant  Shares and/or  Conversion  Shares  thereunder,  taking into account the
Shares, would result in the "beneficial  ownership" (as defined in Section 13(d)
of the  Securities  Exchange  Act of 1934,  as amended,  and  Regulations  13D-G
thereunder) by Xmark LP, Xmark Ltd, or their  affiliates,  of more than 9.99% of
the Common Stock (the "Issuance  Limitation").  Such Issuance  Limitation may be
waived by Xmark LP and/or Xmark Ltd upon 61 days written  notice to the Company.
The  Issuance  Limitation  with  respect to the Initial  Warrants  was waived on
December 30,  2003.  As a result of that waiver,  the Issuance  Limitation  with
respect to the 2003 Warrants and the Conversion shares is currently ineffective.

Xmark Asset  Management,  LLC,  ("XAM"),  a New York limited  liability  company
formerly  known as Brown Simpson  Asset  Management,  LLC,  serves as investment
manager for each of Xmark LP and Xmark Ltd. In such capacity,  XAM possesses the
power to vote and direct the  disposition of all securities held by Xmark LP and
Xmark Ltd.  Thus,  as of December  31, 2003,  for the  purposes of Reg.  Section
240.13d-3,  XAM may be deemed to  beneficially  own  6,394,774  shares of Common
Stock,  or 25.7% of the Common Stock deemed  issued and  outstanding  as of that
date.

The total number of shares of Common Stock  beneficially owned by XAM, including
Warrant Shares and Conversion  Shares is 6,394,774,  or 25.7% of the outstanding
shares  of Common  Stock as of  November  10,  2003  (based  on the  information
provided in the Company's Form 10-Q for the quarterly period ended September 30,
2003).  This does not  include  20,000  shares of Common  Stock and  Warrants to
acquire 533,334 shares of Common Stock owned by certain  employees of XAM, which
were  distributed  by XAM to these  employees  in December,  2003  pursuant to a
letter agreement.  XAM disclaims  beneficial ownership of the securities held by
these  employees.  These total share numbers do include  30,000 shares of Common
Stock and Warrants to acquire  266,666  shares of Common Stock (of which 166,666
were  subject  to an  Issuance  Limitation  which  became  ineffective  upon the
December 30, 2003 waiver of the Issuance  Limitation  described  above) owned by
Sabbatical  Ventures,  LLC, a Delaware limited liability  company  controlled by
Mitchell  D. Kaye.  Mr. Kaye is Manager of XAM.  XAM  acquired  these  shares of
Common Stock and the Warrants to acquire  these shares of Common Stock that were
distributed  to its  employees  pursuant to an Advisory  Agreement,  dated as of
January 15, 2003.


Item 1.   Security and Issuer.
          -------------------

          This statement  relates to the common stock, par value $0.01 per share
("Common  Stock"),  of  Antares  Pharma,  Inc.,  a  Minnesota  corporation  (the
"Company"). The Company has principal executive offices located at 707 Eagleview
Boulevard, Suite 414, Exton, Pennsylvania 19314.


Item 2.   Identity and Background.
          -----------------------

          The person filing this statement is Xmark Asset Management, LLC, a New
York  limited  liability   company,   formerly  known  as  Brown  Simpson  Asset
Management,  LLC ("XAM").  The business  address of XAM is 152 West 57th Street,
21st Floor, New York, New York 10019.





          XAM serves as the investment  manager for Xmark Fund, L.P., a Delaware
limited  partnership  ("Xmark LP"),  Xmark Fund,  Ltd., a Cayman  Islands exempt
company  ("Xmark Ltd") as well as various other  private  investment  funds (the
"Funds").  Xmark LP,  Xmark Ltd and the Funds are engaged in the  investment  in
personal  property of all kinds,  including  but not  limited to capital  stock,
depository  receipts,   investment  companies,   mutual  funds,   subscriptions,
warrants,  bonds,  notes,  debentures,  options and other securities of whatever
kind and nature.

          Mitchell  D.  Kaye,   whose  business   address  is  c/o  Xmark  Asset
Management,  LLC, 152 West 57th Street, 21st Floor, New York, New York 10019, is
the Chief Investment Officer of Xmark LP and Xmark Ltd and the Manager of XAM.

          XAM has never been  convicted  in any criminal  proceeding  (excluding
traffic  violations  or  similar  misdemeanors),  nor has he been a party to any
civil proceeding commenced before a judicial or administrative body of competent
jurisdiction as a result of which he was or is now subject to a judgment, decree
or final order  enjoining  future  violations  of, or  prohibiting  or mandating
activities subject to, federal or state securities laws or finding any violation
with respect to such laws.  XAM is a New York limited liability company.

          Mr.  Kaye  has  never  been  convicted  in  any  criminal   proceeding
(excluding traffic violations or similar misdemeanors),  nor has he been a party
to any civil proceeding  commenced before a judicial or  administrative  body of
competent  jurisdiction  as a  result  of which  he was or is now  subject  to a
judgment,  decree or final order enjoining future  violations of, or prohibiting
or mandating  activities subject to, federal or state securities laws or finding
any  violation  with  respect to such laws.  Mr. Kaye is a citizen of the United
States.


Item 3.   Source and Amount of Funds or Other Consideration.
          -------------------------------------------------

          Pursuant  to a  Securities  Purchase  Agreement,  dated as of July 12,
2002,  by and among the Company,  Xmark LP, Xmark Ltd and certain  other parties
thereto (the "2002  Purchase  Agreement"):  (i) on July 12,  2002,  Xmark LP and
Xmark Ltd  purchased  $40,827.50  and  $134,172.50,  respectively,  in principal
amount of the Company's  10% Secured  Convertible  Debentures,  due July 3, 2003
(the "Initial 2002  Debentures");  (ii) on July 26, 2002, Xmark LP and Xmark Ltd
purchased an additional $40,827.50 and $134,172.50,  respectively,  in principal
amount of the Company's 10% Secured  Convertible  Debentures,  due July 26, 2003
(the "Additional 2002 Debentures");  and (iii) on October 15, 2002, Xmark LP and
Xmark Ltd purchased $34,995 and $115,005,  respectively,  in principal amount of
the  Company's  10% Secured  Convertible  Debentures,  due October 15, 2003 (the
"October 2002  Debentures," and together with the Initial 2002  Debentures,  and
the  Additional  2002  Debentures,  the "2002  Debentures").  Subject to certain
restrictions  contained  in  the  2002  Debentures,  the  holders  of  the  2002
Debentures had the right, at any time, to convert principal and accrued interest
on the 2002 Debentures into Common Stock.  The 2002 Debentures were  convertible
into shares of Common Stock at a  conversion  price per share equal to the lower
of $2.50 or 75% of the average of the three lowest intraday prices of the Common
Stock, as reported on the Nasdaq SmallCap Market. All funds used by Xmark LP and
Xmark Ltd to purchase  or acquire the 2002  Debentures  came  directly  from the
assets of Xmark LP and Xmark Ltd, respectively.  As described below in this Item
3, the 2002 Debentures are no longer outstanding.





          On January  24,  2003 and  January  31,  2003,  Xmark LP and Xmark Ltd
loaned  the  Company an  aggregate  of  approximately  $163,267,  and  $457,757,
respectively.  In exchange for such loans, the Company issued Xmark LP and Xmark
Ltd 30-day 8% promissory  notes in the aggregate  principal  amount of $163,267,
and $457,757,  respectively (the "Promissory Notes"). All funds used by Xmark LP
and Xmark Ltd to purchase or acquire the Promissory Notes came directly from the
assets of Xmark LP and Xmark Ltd, respectively.  As described below in this Item
3, the Promissory Notes are no longer outstanding.

          Pursuant to an Advisory  Agreement,  dated as of January 15, 2003,  by
and between XAM and the Company (the  "Advisory  Agreement"),  XAM was issued an
aggregate of: (i) 50,000 shares of  restricted  Common Stock;  and (ii) warrants
(the "Advisory  Warrants") to purchase,  at any time after the issuance thereof,
up to 800,000 shares of Common Stock.  The Advisory  Warrants have the following
exercise prices: (i) 300,000 of such Advisory Warrants have an exercise price of
$0.55 per share (which  exercise  price is subject to adjustment as set forth in
the Advisory Warrants);  (ii) 250,000 of such Advisory Warrants have an exercise
price of $1.60 per share (which  exercise  price is subject to adjustment as set
forth in the Advisory Warrants);  (iii) 250,000 of such Advisory Warrant have an
exercise price of $1.82 per share (which exercise price is subject to adjustment
as set forth in the Advisory Warrants).  These 50,000 shares of Common Stock and
Advisory  Warrants were issued  pursuant to the terms of the Advisory  Agreement
and not for  additional  cash  consideration.  As described  below in Item 6, in
December, 2003 XAM distributed these shares and the Advisory Warrants to certain
employees of XAM.

          Pursuant to a Debenture and Warrant Agreement, dated as of January 31,
2003, by and among the Company, Xmark LP, and Xmark Ltd (the "Debenture Purchase
Agreement"),  in  consideration  for the surrender of the Promissory  Notes: (i)
Xmark LP was issued (A) an 8% Senior Secured  Convertible  Debenture,  due March
31, 2004, in principal  amount of $163,267.45 (the "Xmark LP Debenture") and (B)
a warrant (the  "Initial  Xmark LP Warrant") to purchase,  at any time after the
issuance  thereof,  subject to certain  restrictions  contained  therein,  up to
394,350 shares of Common Stock, at an initial  exercise price of $0.55 per share
(which exercise price is subject to adjustment as set forth in the Initial Xmark
LP Warrant,  and was subsequently  adjusted to $0.28 per share);  and (ii) Xmark
Ltd was issued (A) an 8% Senior  Secured  Convertible  Debenture,  due March 31,
2004,  in  principal  amount of  $457,757.47  (the  "Xmark Ltd  Debenture,"  and
together with the Xmark LP Debenture,  the  "Debentures") and (B) a warrant (the
"Initial Xmark Ltd Warrant," and together with the Initial Xmark LP Warrant, the
"Initial Warrants") to purchase, at any time after the issuance thereof, subject
to certain  restrictions  contained  therein,  up to 1,105,650  shares of Common
Stock, at an initial  exercise price of $0.55 per share (which exercise price is
subject to  adjustment  as set forth in the Initial  Xmark Ltd Warrant,  and was
subsequently  adjusted  to $0.28 per  share).  Subject to  certain  restrictions
contained in the  Debentures,  principal and accrued  interest on the Debentures
could be converted, at any time after the issuance thereof, into Common Stock at
a  conversion  price of $0.50 per share (which  conversion  price was subject to
adjustment as set forth in the Debentures).  Xmark LP and Xmark Ltd acquired the
Debentures  and the  Initial  Warrants in  consideration  for  surrender  of the
Promissory Notes.

          Pursuant to a separate Debenture and Warrant Agreement,  also dated as
of January 31, 2003, by and among the Company, Xmark LP, Xmark Ltd and the other
parties  named  therein  (the  "Restated  Debenture  Purchase  Agreement"),   in
consideration  for the surrender of the 2002  Debentures  (including all accrued
interest thereon):  (i) Xmark LP was issued (A) an 8% Senior Secured Convertible





Debenture, due March 31, 2004, in principal amount of $121,949.81 (the "Restated
Xmark LP Debenture")  and (B) a warrant (the  "Additional  Xmark LP Warrant") to
purchase,   at  any  time  after  the  issuance  thereof,   subject  to  certain
restrictions  contained  therein,  up to 174,975  shares of Common Stock,  at an
initial  exercise  price of $0.55 per share (which  exercise price is subject to
adjustment as set forth in the Additional Xmark LP Warrant, and was subsequently
adjusted  to $0.28 per  share);  and (ii)  Xmark Ltd was issued (A) an 8% Senior
Secured  Convertible  Debenture,  due March 31,  2004,  in  principal  amount of
$400,766.92  (the "Restated Xmark Ltd Debenture," and together with the Restated
Xmark  LP  Debenture,   the  "Restated  Debentures")  and  (B)  a  warrant  (the
"Additional  Xmark Ltd  Warrant,"  and,  together with the  Additional  Xmark LP
Warrant, the "Additional  Warrants") to purchase, at any time after the issuance
thereof, subject to certain restrictions contained therein, up to 575,025 shares
of Common Stock, at an initial exercise price of $0.55 per share (which exercise
price is subject to adjustment as set forth in the Additional Xmark Ltd Warrant,
and  was  subsequently  adjusted  to  $0.28  per  share).   Subject  to  certain
restrictions  contained  in  the  Restated  Debentures,  principal  and  accrued
interest on the Restated  Debentures  could be converted,  at any time after the
issuance  thereof,  into Common Stock at a  conversion  price of $0.50 per share
(which  conversion  price is subject to  adjustment as set forth in the Restated
Debentures).  Xmark LP and Xmark Ltd acquired the  Restated  Debentures  and the
Additional Warrants in consideration for surrender of the 2002 Debentures.

          Pursuant  to a Purchase  Agreement,  dated as of July 7, 2003,  by and
among the Company,  Xmark LP, Xmark Ltd and certain other  parties  thereto (the
"Purchase  Agreement"),  on July 8, 2003:  (i) Xmark LP  purchased  (A)  317,500
shares of Common  Stock at a price of $1.00 per  share,  and (B)  warrants  (the
"2003 Xmark LP Warrants") to purchase up to 238,125 shares of Common Stock;  and
(ii) Xmark Ltd purchased (A) 682,500  shares of Common Stock at a price of $1.00
per share,  and (B) warrants (the "2003 Xmark Ltd  Warrants,"  and together with
the 2003 Xmark LP  Warrants,  the "2003  Warrants")  to  purchase  up to 511,875
shares of Common Stock.  Subject to certain  restrictions  contained in the 2003
Warrants,  the 2003 Warrants are exercisable at any time on or after the date of
issuance  thereof at an  exercise  price of $1.25 per share  (subject to certain
exercise price  adjustments  contained  therein).  All funds used to purchase or
acquire the securities in connection  with the Purchase  Agreement came directly
from the assets of Xmark LP and Xmark Ltd.

          Pursuant to a Securities Exchange Agreement, dated as of September 12,
2003, by and among the Company,  Xmark LP, Xmark Ltd and the other parties named
therein (the "Exchange  Agreement"),  in consideration  for the surrender of the
outstanding portion of the Restated  Debentures  (including all accrued interest
thereon):  (i) Xmark LP (A) was issued  44,927  shares  (the  "Xmark LP Series D
Preferred  Shares") of the Company's  Series D Convertible  Preferred Stock, par
value  $0.01 per share  (the  "Series D  Preferred  Stock"),  each of which such
shares,  subject to certain restrictions  contained in the Company's Certificate
of Designations of Series D Preferred Stock (the "Certificate of Designations"),
is  convertible  into ten shares of Common  Stock,  for an  aggregate of 449,270
shares of Common  Stock (the "Xmark LP  Conversion  Shares"),  (B) the  exercise
price of the Initial  Xmark LP Warrant was reduced from $0.55 to $0.40,  and (C)
the exercise price of the Additional  Xmark LP Warrant was reduced from $0.55 to
$0.40;  and (ii) Xmark Ltd (A) was issued 135,234 shares of the Company's Series
D Preferred Stock (the "Xmark Ltd Series D Preferred Shares," and, together with
the Xmark LP Series D Preferred Shares, the "Preferred  Shares"),  each of which
such shares,  subject to certain  restrictions  contained in the  Certificate of
Designation, is convertible into ten shares of Common Stock, for an aggregate of





1,352,340  shares of Common  Stock (the  "Xmark  Ltd  Conversion  Shares,"  and,
together with the Xmark LP Conversion Shares, the "Conversion Shares"),  (B) the
exercise price of the Initial Xmark Ltd Warrant was reduced from $0.55 to $0.40,
and (C) the exercise price of the Additional  Xmark Ltd Warrant was reduced from
$0.55 to $0.40. Xmark LP and Xmark Ltd acquired the Preferred Shares in exchange
for  surrender  of the Restated  Debentures.  Also on  September  12,  2003,  an
aggregate  amount of $300,000 of the Debentures were converted into an aggregate
of 599,998 shares of Common Stock at a conversion price of $0.50 per share.

          The Initial  Warrants,  the Additional  Warrants and the 2003 Warrants
and the  Certificate of Designations  with respect to the Preferred  Shares each
provides  that in no event shall the  Preferred  Shares be  convertible,  or the
Initial Warrants,  Additional  Warrants or 2003 Warrants be exercisable,  to the
extent that the issuance of Common Stock upon such conversion  and/or  exercise,
would result in the  "beneficial  ownership" (as defined in Section 13(d) of the
Securities  Exchange Act of 1934, as amended,  and Regulations 13D-G thereunder)
by Xmark LP,  Xmark Ltd or their  affiliates,  of more than  9.99% of the Common
Stock (the  "Issuance  Limitation").  Such Issuance  Limitation may be waived by
Xmark LP  and/or  Xmark Ltd upon 61 days  written  notice  to the  Company.  The
Issuance  Limitation  with respect to the Initial  Warrants  and the  Additional
Warrants  was  waived on  December  30,  2003.  As a result of the  waiver,  the
Issuance  Limitation with respect to the Preferred  Shares and the 2003 Warrants
is currently ineffective.


Item 4.   Purpose of Transaction.
          ----------------------

          The acquisition of the securities referred to herein is for investment
purposes.  Pursuant to the terms of the  Purchase  Agreement,  Xmark Fund LP and
Xmark Fund Ltd have the right to designate one (1) person for  nomination to the
Company's Board of Directors (the  "Designee").  In connection with the Purchase
Agreement, the Company, Xmark LP, Xmark Ltd, Dr. Jacques Gonella (a director and
principal  shareholder  of the Company) and  Permatech  Holdings AG (a principal
shareholder of the Company) entered into a Voting Agreement, dated as of July 7,
2003 (the "Voting  Agreement")  pursuant to which  the Company,  Dr. Gonella and
Permatech  Holdings AG agreed,  among other things,  to take all actions  within
their  respective  control to ensure the nomination and election to the Board of
Directors of the Designee.

          Other than as set forth above in this Item 4, XAM has no present plans
or  intentions  which  relate  to or  would  result  in any of the  transactions
required to be described in Item 4 of Schedule 13D.


Item 5.   Interest in Securities of the Issuer.
          ------------------------------------

          Based upon information  derived from the Company's Quarterly Report on
Form 10-Q for the period ended September 30, 2003, as of November 10, 2003 there
were 19,791,296  shares of Common Stock issued and  outstanding.  As of December
31, 2003,  Xmark LP and Xmark Ltd own, in aggregate,  1,296,498 shares of Common
Stock.  As of December  31,  2003,  based on the December 30, 2003 waiver of the
Issuance  Limitation  with respect to the Initial  Warrants  and the  Additional
Warrants,  Xmark LP and Xmark Ltd  beneficially  own 6,128,108  shares of Common
Stock.

          XAM  possesses  sole power to vote and direct the  disposition  of all
securities  held by Xmark LP and Xmark Ltd.  Thus, as of December 31, 2003,  for
the purposes of Reg. Section 240.13d-3,  XAM, the investment manager for each of
Xmark LP and Xmark Ltd, may be deemed to  beneficially  own 6,394,774  shares of





Common  Stock,  or 25.7%  of the  shares  of  Common  Stock  deemed  issued  and
outstanding as of that date.  Such amount includes 30,000 shares of Common Stock
and  warrants to acquire  266,666  shares of Common  Stock  owned by  Sabbatical
Ventures,  LLC, a limited liability controlled by Mitchell D. Kaye.  Such amount
does not include  20,000 shares of Common Stock and Warrants to acquire  533,334
shares of Common Stock owned by certain employees of XAM, which were distributed
by XAM to  these  employees  in  December,  2003.  In  addition,  XAM  expressly
disclaims  beneficial  ownership of the Common Stock  beneficially  owned by the
other parties to the Voting Agreement.

          Between July 8, 2003 and 60 days prior to December 31, 2003,  Xmark LP
and Xmark Ltd sold an aggregate of 191,500 shares of Common Stock in open market
transactions.  As a result of the  Issuance  Limitation  then in  effect,  XAM's
beneficial ownership did not change due to such transactions.

          In addition to the  transactions  described above, the following table
details the transactions during the 60 days prior to December 31, 2003 in Common
Stock, or securities  convertible  into,  exercisable  for or  exchangeable  for
Common Stock, by XAM or any person or entity  controlled by XAM or any person or
entity for which XAM possesses voting or investment  control over the securities
thereof (each of which was effected in an ordinary brokerage transaction).


                                   I. Xmark LP
                                   -----------

                                   (Purchases)

     Date                          Quantity                Price Per Share
     ----                          --------                ---------------

                                      NONE


                                     (Sales)

     Date                          Quantity                Price Per Share
     ----                          --------                ---------------

   November 6, 2003                  3,778                     $1.45
   November 7, 2003                  2,519                     $1.49
   November 11, 2003                   252                     $1.39
   November 12, 2003                   252                     $1.37
   November 13, 2003                 3,276                     $1.42
   November 14, 2003                 1,259                     $1.50
   November 17, 2003                 1,259                     $1.48
   November 19, 2003                10,327                     $1.53
   November 20, 2003                 6,045                     $1.53
   November 28, 2003                 2,519                     $1.26
   December 9, 2003                  1,259                     $1.25






                                  II. Xmark Ltd
                                  -------------

                                   (Purchases)

     Date                          Quantity                Price Per Share
     ----                          --------                ---------------

                                      NONE


                                     (Sales)

     Date                          Quantity                Price Per Share
     ----                          --------                ---------------

   November 6, 2003                 11,222                     $1.45
   November 7, 2003                  7,481                     $1.49
   November 11, 2003                   748                     $1.39
   November 12, 2003                   748                     $1.37
   November 13, 2003                 9,724                     $1.42
   November 14, 2003                 3,741                     $1.50
   November 17, 2003                 3,741                     $1.48
   November 19, 2003                30,673                     $1.53
   November 20, 2003                17,955                     $1.53
   November 28, 2003                 7,481                     $1.26
   December 9, 2003                  3,741                     $1.25



Item 6.   Contracts, Arrangements, Understandings or Relationships With  Respect
          to Securities of the Issuer.
          ----------------------------------------------------------------------

          In connection with the purchase of the 2002 Debentures, in addition to
the 2002  Purchase  Agreement,  Xmark  LP and  Xmark  Ltd  entered  into:  (i) a
Registration  Rights Agreement,  dated July 12, 2002,  pursuant to which,  among
other  things,  the  Company,  Xmark Fund LP,  Xmark Fund Ltd and certain  other
parties agreed to the terms pursuant to which the Company agreed to register the
shares of Common Stock  issuable  upon  conversion  of the 2002  Debentures  for
resale  by the  filing  of a  registration  statement  with the  Securities  and
Exchange  Commission pursuant to the Securities Act of 1933, as amended, as well
as  perform   various  other   obligations   and  agreements   related  to  such
registration;  and (ii) a Security Agreement,  dated July 12, 2002 (the "Initial
Security Agreement"), pursuant to which, among other things, the Company granted
the parties named therein a security interest in substantially all of the assets
of the Company to secure the Company's payment  obligations under the debentures
issued pursuant to the 2002 Purchase Agreement.  In addition, the Company issued
to Xmark LP and Xmark Ltd the 2002 Debentures.

          In  connection  with the purchase of the  Debentures  and the Restated
Debentures,  in addition to the  Debenture  Purchase  Agreement and the Restated
Debenture  Purchase  Agreement,  Xmark LP and  Xmark  Ltd  entered  into:  (i) a
Registration Rights Agreement,  dated January 31, 2003, pursuant to which, among
other  things,  the  Company,  Xmark Fund LP,  Xmark Fund Ltd and certain  other
parties agreed to the terms pursuant to which the Company agreed to register the
shares of Common  Stock  issuable  upon  conversion  of the  Debentures  and the





Restated  Debentures,  and the shares of Common Stock  issuable upon exercise of
the Initial Warrants and the Additional Warrants,  for resale by the filing of a
registration  statement with the Securities and Exchange  Commission pursuant to
the  Securities  Act of 1933,  as  amended,  as well as  perform  various  other
obligations and agreements related to such registration; and (ii) an Amended and
Restated  Security  Agreement,  dated  January 31,  2003,  which such  agreement
amended and restated to Initial  Security  Agreement,  pursuant to which,  among
other things,  the Company granted the parties named therein a security interest
in  substantially  all of the  assets of the  Company  to secure  the  Company's
payment  obligations  under the  debentures  issued  pursuant  to the  Debenture
Purchase Agreement and the Restated Debenture Purchase  Agreement.  In addition,
the  Company  issued  to Xmark LP and  Xmark Ltd the  Debentures,  the  Restated
Debentures, the Initial Warrants and the Additional Warrants.

          In addition,  pursuant to the terms of each of the Debenture  Purchase
Agreement and the Restated Debenture Agreement,  the Company agreed, among other
things,  to: (i) solicit proxies from the shareholders of the Company to vote in
favor of the approval of the issuance of shares of Common  Stock  issuable  upon
conversion of the Debentures and the Restated  Debentures in connection with the
transactions  contemplated by the Debenture  Purchase Agreement and the Restated
Debenture Purchase Agreement, greater in the aggregate than 19.99% of the number
of  shares  of  Common  Stock  outstanding  prior  to  the  consummation  of the
transactions  contemplated by the Debenture  Purchase Agreement and the Restated
Debenture  Purchase  Agreement;  and (ii)  cause the board of  directors  of the
Company to  recommend  to the  stockholders  that they  approve  such  proposal.
Additionally,  the Company granted each of the parties to the Debenture Purchase
Agreement and the Restated Debenture Purchase Agreement, the right, for a period
expiring on January  31,  2005,  to  participate  (as a  purchaser  and not as a
seller)  in any  proposed  sale by the  Company of any  equity  security  or any
security which is convertible into or exercisable for any equity security.

          In  connection  with the  Advisory  Agreement,  XAM agreed to act as a
non-exclusive  financial  advisor  to the  Company.  The  term  of the  Advisory
Agreement  commenced on January 15, 2003 and the  agreement may be terminated by
either party for any reason upon 10 days advance written  notice.  In connection
with the Advisory  Agreement,  XAM was issued 50,000 shares of restricted Common
Stock and the Advisory  Warrants to acquire  800,000 shares of Common Stock,  as
described in Item 3 above. In addition,  the Company agreed to reimburse XAM for
reasonable  out-of-pocket  expenses incurred by XAM in providing  services under
the Advisory Agreement and, subject to certain exceptions,  to indemnify XAM and
its  affiliates  in  connection  with  services   provided  under  the  Advisory
Agreement. In December, 2003, the securities held by XAM were distributed by XAM
to certain of its employees.

          In connection  with the July 2003 purchase of the 1,000,000  shares of
Common Stock and the 2003 Warrants, in addition to the Purchase Agreement, Xmark
LP and Xmark Ltd entered into: (i) a Registration  Rights Agreement,  dated July
7, 2003,  pursuant to which,  among other  things,  the Company,  Xmark Fund LP,
Xmark Fund Ltd and certain other parties  agreed to the terms  pursuant to which
the Company  agreed to register the shares of Common Stock  purchased  under the
Purchase  Agreement and the shares of Common Stock  issuable upon  conversion of
the 2003 Warrants for resale by the filing of a registration  statement with the
Securities  and Exchange  Commission  pursuant to the Securities Act of 1933, as
amended,  as well as perform various other obligations and agreements related to
such registration; and (ii) the Voting Agreement, pursuant to which, among other
things,  the Company,  Dr. Gonella and Permatech  Holdings AG agreed to take all



actions within their receptive  control to ensure the nomination and election to
the Board of Directors of the Designee. In addition, the Company issued to Xmark
LP and Xmark Ltd the 2003 Warrants. XAM expressly disclaims beneficial ownership
of the  Common  Stock  beneficially  owned by the other  parties  to the  Voting
Agreement.

          The  descriptions of the transactions and agreements set forth in this
Amendment No. 1 to Schedule 13D are qualified in their  entirety by reference to
the complete agreements  governing such matters,  each of which are incorporated
by reference to this Schedule 13D as exhibits pursuant to Item 7 hereof.

          Except as otherwise  described  herein,  no  contracts,  arrangements,
understandings or similar  relationships exist with respect to the securities of
the Company between XAM and any person or entity.


Item 7.   Material to be Filed as Exhibits.
          --------------------------------

          1.   Securities Purchase Agreement,  dated as of July 12, 2002,  among
Antares  Pharma,  Inc.,  Xmark Fund,  LP, Xmark Fund,  Ltd.,  and certain  other
parties  identified  therein,  incorporated by reference to Exhibit 10.29 to the
Current Report on Form 8-K, dated July 17, 2002, filed by Antares Pharma, Inc.

          2.   Registration Rights  Agreement,  dated as of July 12, 2002, among
Antares  Pharma,  Inc.,  Xmark Fund,  LP, Xmark Fund,  Ltd.,  and certain  other
parties  identified  therein,  incorporated by reference to Exhibit 10.30 to the
Current Report on Form 8-K, dated July 17, 2002, filed by Antares Pharma, Inc.

          3.   Security Agreement,  dated as of July  12,  2002,  among  Antares
Pharma,  Inc.,  Xmark Fund,  LP, Xmark Fund,  Ltd.,  and certain  other  parties
identified  therein,  incorporated  by reference to Exhibit 10.31 to the Current
Report on Form 8-K, dated July 17, 2002, filed by Antares Pharma, Inc.

          4.   Form of  Secured  Convertible  Debenture,  dated  July 12,  2002,
issued  by  Antares  Pharma,  Inc.  to Xmark  Fund,  LP and  Xmark  Fund,  Ltd.,
incorporated  by reference to Exhibit  10.32 to the Current  Report on Form 8-K,
dated July 17, 2002, filed by Antares Pharma, Inc.

          5.   Debenture and Warrant Purchase Agreement, dated as of January 31,
2003, among Antares Pharma,  Inc., Xmark Fund, LP, Xmark Fund, Ltd., and certain
other parties identified therein,  incorporated by reference to Exhibit 10.39 to
the  Current  Report on Form 8-K,  dated  February  12,  2003,  filed by Antares
Pharma, Inc.

          6.   Debenture and Warrant Purchase Agreement, dated as of January 31,
2003,  among  Antares  Pharma,  Inc.,  Xmark  Fund,  LP, and Xmark  Fund,  Ltd.,
incorporated  by reference to Exhibit  10.40 to the Current  Report on Form 8-K,
dated February 12, 2003, filed by Antares Pharma, Inc.

          7.   Registration  Rights  Agreement,  dated  as of  January 31, 2003,
among Antares Pharma,  Inc., Xmark Fund, LP, Xmark Fund, Ltd., and certain other
parties  identified  therein,  incorporated by reference to Exhibit 10.41 to the




Current Report on Form 8-K, dated  February 12, 2003,  filed by Antares  Pharma,
Inc.

          8.   Amended and Restated Security  Agreement, dated as of January 31,
2003, among Antares Pharma,  Inc., Xmark Fund, LP, Xmark Fund, Ltd., and certain
other parties identified therein,  incorporated by reference to Exhibit 10.42 to
the  Current  Report on Form 8-K,  dated  February  12,  2003,  filed by Antares
Pharma, Inc.

          9.   Form  of  Warrants,  dated  January 31, 2003,  issued by  Antares
Pharma,  Inc. to each of Xmark Fund, L.P. and Xmark Fund, Ltd.,  incorporated by
reference to Exhibit 10.43 to the Current Report on Form 8-K, dated February 12,
2003, filed by Antares Pharma, Inc.

          10.  Form of 8% Senior Secured  Convertible Debentures,  dated January
31, 2003,  issued by Antares Pharma,  Inc. to each of Xmark Fund, L.P. and Xmark
Fund, Ltd.,  incorporated by reference to Exhibit 10.44 to the Current Report on
Form 8-K, dated February 12, 2003, filed by Antares Pharma, Inc.

          11.  Form of  Amended  and  Restated  8%  Senior  Secured  Convertible
Debentures,  dated January 31, 2003,  issued by Antares Pharma,  Inc. to each of
Xmark Fund,  L.P.  and Xmark Fund,  Ltd.,  incorporated  by reference to Exhibit
10.45 to the Current  Report on Form 8-K,  dated  February  12,  2003,  filed by
Antares Pharma, Inc.

          12.  Form of Promissory Notes, dated January 24, 2003, and January 31,
2003, issued by Antares Pharma, Inc. to each of Xmark Fund, L.P. and Xmark Fund,
Ltd.,  incorporated  by reference to Exhibit 10.46 to the Current Report on Form
8-K, dated February 12, 2003, filed by Antares Pharma, Inc.

          13.  Purchase  Agreement,  dated  as of July 7,  2003,  among  Antares
Pharma,  Inc.,  Xmark Fund,  LP, Xmark Fund,  Ltd.,  and certain  other  parties
identified  therein,  incorporated  by reference to Exhibit 10.48 to the Current
Report on Form 8-K, dated July 9, 2003, filed by Antares Pharma, Inc.

          14.  Registration  Rights  Agreement,  dated as of July 7, 2003, among
Antares  Pharma,  Inc.,  Xmark Fund,  LP, Xmark Fund,  Ltd.,  and certain  other
parties  identified  therein,  incorporated by reference to Exhibit 10.49 to the
Current Report on Form 8-K, dated July 9, 2003, filed by Antares Pharma, Inc.

          15.  Voting Agreement, dated as of July 9, 2003, among Antares Pharma,
Inc., Xmark Fund, LP, Xmark Fund, Ltd., Dr. Jacques Gonella and Permatec Holding
AG,  incorporated  by reference to Exhibit  10.50 to the Current  Report on Form
8-K, dated July 7, 2003, filed by Antares Pharma, Inc.

          16.  Form of  Warrants,  dated  January  31,  2003,  issued by Antares
Pharma,  Inc. to each of Xmark Fund, L.P. and Xmark Fund, Ltd.,  incorporated by
reference  to Exhibit  10.51 to the  Current  Report on Form 8-K,  dated July 9,
2003, filed by Antares Pharma, Inc.





          17.  Securities  Exchange  Agreement,  dated as of September  12, 2003
among Antares Pharma,  Inc., Xmark Fund, LP, Xmark Fund, Ltd., and certain other
parties  identified  therein,  incorporated by reference to Exhibit 10.57 to the
Current Report on Form 8-K, dated  September 15, 2003,  filed by Antares Pharma,
Inc.

          18.  Certificate of  Designations,  Preferences and Rights of Series D
Convertible  Preferred Stock of Antares Pharma, Inc.,  incorporated by reference
to Exhibit 3.8 to the Current  Report on Form 8-K,  dated  September  15,  2003,
filed by Antares Pharma, Inc.

          19.  Letter Agreement,  dated  November 26, 2003,  among Brown Simpson
Asset  Management,  LLC and certain employees of Brown Simpson Asset Management,
LLC.







                                   Signature
                                   ---------

          After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information  set forth in this statement is true,  complete and
correct.


                                            January 12, 2004

                                            XMARK ASSET MANAGEMENT, LLC

                                            /s/ Mitchell D. Kaye
                                            ------------------------------------
                                            Mitchell D. Kaye, Manager


Attention:  Intentional  misstatements  or omissions of fact constitute  Federal
criminal violations (See 18 U.S.C. 1001).









                                   Exhibit 19


                Letter Agreement, dated November 26, 2003, among
          Brown Simpson Asset Management, LLC and certain employees of
                      Brown Simpson Asset Management, LLC.










                       BROWN SIMPSON ASSET MANAGEMENT, LLC
                              152 West 57th Street
                               New York, New York


                                November 26, 2003


Re:    Warrants to Acquire Common Stock of Antares Pharma, Inc.


To the Undersigned
  Recipient of Re-issued Warrants:

As you know,  Antares Pharma,  Inc. (Antares) has issued warrants to acquire its
common  stock to Brown  Simpson  Asset  Management,  LLC (BSAM)  pursuant  to an
Advisory  Agreement,  dated  January 15, 2003 between  BSAM and Antares.  We are
going to request that Antares permit the transfer of these warrants from BSAM to
certain of BSAM's  employees  before year end.  Although this re-issuance of the
warrants will not be a taxable event, you may nevertheless  want to consult with
your tax advisor. Our understanding is that the taxable event occurs at the time
the warrant is exercised;  once again, you should confirm this with your own tax
advisor.

In order to  facilitate  this  re-issuance,  please  provide  the exact name and
address in which you want the warrant re-issued  (Re-issued  Warrants).  We will
pass that  information  along to Antares.  If you want the  warrant  issued to a
limited liability company in which you are the sole member, you may provide that
entity's information instead.

There will be certain  restrictions  and  forfeiture  provisions  imposed on the
Re-issued  Warrants,  which are set forth below. These restrictions apply to all
warrants issued from time to time by Antares pursuant to the Advisory Agreement,
in addition to the  warrants  being  re-issued  in  connection  with this letter
agreement.  In consideration of the distribution of the warrants as contemplated
in this letter  agreement,  you agree to be bound by the terms and conditions of
this letter agreement.

A.   Sales of shares issued upon exercise of the Re-issued Warrants to each of
the  undersigned  will be limited to no more than 1,000 shares per day.  This is
not an average,  but rather,  an absolute  daily cap. If any of the  undersigned
violates  this  limitation,  that person (or  entity,  as the case may be) shall
immediately  upon  request of BSAM forfeit and  surrender to BSAM all  remaining
warrants and other securities issued by Antares beneficially or legally owned by
such person (or entity),  and BSAM shall have the right to seek, and such person
(or entity) shall be liable to BSAM for, such further damages as BSAM may suffer
resulting from such  violation.  Each of the  undersigned  shall provide written
notice to BSAM  within two  business  days  after  his/her/its  exercise  of any
Re-issued Warrants and sales of shares issued upon the exercise thereof.

B.   If, at any  time,  BSAM has the  opportunity  to trade  (or exercise before
expiration)  the Re-issued  Warrants for  securities or other property that BSAM
deems to be of equal,  greater or better value than the Re-issued  Warrants,  as
determined by BSAM in its sole discretion, each recipient of Re-issued Warrants,
upon request therefor,  must surrender his/its/her Re-issued Warrants to BSAM in
exchange for the new security or property.

C.   None of the Re-issued Warrants shall be transferred , in whole or  in part,
by any of the undersigned  without BSAM's express prior written  consent,  which
may be given or withheld in its sole discretion.

D.   As  and when  requested,  each recipient  of  Re-issued Warrants  agrees to
provide BSAM with its tax  identification  number and such other  information as
may  reasonably  be  requested  in  order  to  enable  BSAM to  comply  with all
applicable tax and other laws, rules and regulations.

E.   BSAM makes no representations or warranties to you about the securities law
restrictions  that  may be  imposed  on the  Re-issued  Warrants  or the  shares
issuable upon exercise thereof, or whether any of them has been registered or is



subject  to  an  effective  registration  statement.  As  professionals  in  the
securities and investment industries,  each of the undersigned acknowledges that
he (or it) is fully familiar with the  restrictions  imposed on unregistered and
otherwise restricted securities pursuant to applicable securities laws.

F.   Each of  the undersigned acknowledges  and agrees that (x) the restrictions
imposed in this letter  agreement are reasonable  and  necessary,  and that they
have  been  freely   bargained  for  by  the  parties,   and  (y)  without  such
restrictions,  BSAM would not have distributed the Re-issued  Warrants,  and (z)
the undersigned shall not sell, pledge, hypothecate,  transfer, gift, assign any
interest in or otherwise  dispose of, any  Re-issued  Warrants or shares  issued
upon  the  exercise  thereof  if  BSAM  advises  the  undersigned,  in its  sole
discretion,  that such action is prohibited in order for BSAM or the undersigned
to comply with applicable  securities laws  (including  without  limitation laws
against  insider  trading) until further advised in writing by BSAM, in its sole
discretion,  that such compliance is no longer necessary.  This letter agreement
constitutes the entire agreement of the parties hereto, and supersedes all prior
oral and written  agreements  concerning the subject matter hereof.  This letter
agreement shall be governed by the laws of the State of New York, without regard
to its conflicts of law rules.  BSAM and each of the undersigned  consent to the
non-exclusive  personal  jurisdiction of the state and federal courts located in
New York County, New York with respect to this letter agreement.  The prevailing
party in a dispute  to  enforce  this  letter  agreement  shall be  entitled  to
reasonable attorneys' fees and expenses.  The terms of this letter agreement are
not  revocable  without  BSAM's  prior  written  consent,  which may be given or
withheld  in its  discretion.  This  letter  agreement  shall  not be  assigned,
amended,  waived  or  modified,  except  by a  writing  signed  by BSAM  and the
applicable undersigned. This letter agreement shall be binding upon and inure to
the  benefit  of the  parties  and their  respective  permitted  successors  and
assigns. This letter agreement may be executed in one or more counterparts,  and
each such  counterpart  shall be deemed an original.  Given the unique nature of
the subject matter of this letter agreement,  BSAM shall be entitled to specific
performance,  injunctive and other  equitable  relief in the enforcement of this
letter  agreement.  For  purposes of  emphasis  and  clarification,  this letter
agreement  applies to all  warrants  issued  from time to time  pursuant  to the
Advisory Agreement.

Except  to the  extent  necessary  for BSAM and the Xmark  Funds to comply  with
applicable  securities  laws,  paragraphs  A, B and C above shall cease to apply
once the Xmark Funds and BSAM cease to own any securities issued by Antares, its
successors or assigns.

Upon receipt of the requested name and address information,  and a countersigned
copy of this  letter  agreement,  BSAM will  request  Antares  to  re-issue  the
warrants as contemplated herein.

Very truly yours,

BROWN SIMPSON ASSET MANAGEMENT, LLC


By:
   -----------------------------------------
Name:
     ---------------------------------------
Title:
      --------------------------------------





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