UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549
                                 SCHEDULE 13G/A
                                (Amendment No. 2)
                    UNDER THE SECURITIES EXCHANGE ACT OF 1934


                            CYTORI THERAPEUTICS, INC.
--------------------------------------------------------------------------------
                                (Name of Issuer)

                                  COMMON STOCK
 -------------------------------------------------------------------------------
                         (Title of Class of Securities)

                                    23283K105
 -------------------------------------------------------------------------------
                                 (CUSIP Number)

                                DECEMBER 31, 2010
--------------------------------------------------------------------------------
             (Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule
is filed:

|X|      Rule 13d-1(b)
|_|      Rule 13d-1(c)
|_|      Rule 13d-1(d)

*The remainder of this cover page shall be filled out for a reporting person's
initial filing on this form with respect to the subject class of securities, and
for any subsequent amendment containing information which would alter the
disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the Securities Exchange Act of
1934 ("Act") or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, see the
Notes).



PERSONS WHO ARE TO RESPOND TO THE COLLECTION OF INFORMATION CONTAINED IN THIS
FORM ARE NOT REQUIRED TO RESPOND UNLESS THE FORM DISPLAYS A CURRENTLY VALID OMB
CONTROL NUMBER.

SEC 1745 (12-02)







                         

--------- ------------------------------------------------------------------------------------------------------------
1.
          NAMES OF REPORTING PERSONS
          I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)

          GAGNON SECURITIES LLC

--------- ------------------------------------------------------------------------------------------------------------
--------- ------------------------------------------------------------------------------------------------------------
2.
          CHECK THE APPROPRIATE BOX IF A GROUP*                                                            (a)
                                                                                                           (b) |X|
--------- ------------------------------------------------------------------------------------------------------------
--------- ------------------------------------------------------------------------------------------------------------
3.        SEC USE ONLY



--------- ------------------------------------------------------------------------------------------------------------
--------- ------------------------------------------------------------------------------------------------------------
4.
          CITIZENSHIP OR PLACE OF ORGANIZATION

          DELAWARE LIMITED LIABILITY COMPANY

--------- ------------------------------------------------------------------------------------------------------------
------------------- ----- --------------------------------------------- ----------------------------------------------
    NUMBER OF       5.
      SHARES              SOLE VOTING POWER                                                                         0
------------------- ----- --------------------------------------------- ----------------------------------------------
------------------- ----- --------------------------------------------- ----------------------------------------------
   BENEFICIALLY     6.
     OWNED BY             SHARED VOTING POWER                                                               1,043,105
------------------- ----- --------------------------------------------- ----------------------------------------------
------------------- ----- --------------------------------------------- ----------------------------------------------
       EACH         7.
    REPORTING             SOLE DISPOSITIVE POWER                                                                    0
------------------- ----- --------------------------------------------- ----------------------------------------------
------------------- ----- --------------------------------------------- ----------------------------------------------
   PERSON WITH:     8.
                          SHARED DISPOSTIVE POWER                                                           1,043,105
------------------- ----- --------------------------------------------- ----------------------------------------------
--------- ---------------------------------------------------------------------------- -------------------------------
9.
          AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON                                      1,043,105
--------- ---------------------------------------------------------------------------- -------------------------------
--------- ------------------------------------------------------------------------------------------------------------
10.
          CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS)
--------- ------------------------------------------------------------------------------------------------------------
--------- ---------------------------------------------------------------------------- -------------------------------
11.
          PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)                                                     2.1 %
--------- ---------------------------------------------------------------------------- -------------------------------
--------- ---------------------------------------------------------------------------- -------------------------------
12.
          TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)                                                    IA
--------- ---------------------------------------------------------------------------- -------------------------------









--------- ------------------------------------------------------------------------------------------------------------
13.
          NAMES OF REPORTING PERSONS
          I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)

          NEIL GAGNON

--------- ------------------------------------------------------------------------------------------------------------
--------- ------------------------------------------------------------------------------------------------------------
14.
          CHECK THE APPROPRIATE BOX IF A GROUP*                                                            (a)
                                                                                                           (b) |X|
--------- ------------------------------------------------------------------------------------------------------------
--------- ------------------------------------------------------------------------------------------------------------
15.       SEC USE ONLY



--------- ------------------------------------------------------------------------------------------------------------
--------- ------------------------------------------------------------------------------------------------------------
16.
          CITIZENSHIP OR PLACE OF ORGANIZATION

          USA

--------- ------------------------------------------------------------------------------------------------------------
------------------- ----- --------------------------------------------- ----------------------------------------------
    NUMBER OF       17.                                                                                       918,482
      SHARES              SOLE VOTING POWER
------------------- ----- --------------------------------------------- ----------------------------------------------
------------------- ----- --------------------------------------------- ----------------------------------------------
   BENEFICIALLY     18.                                                                                     1,292,824
     OWNED BY             SHARED VOTING POWER
------------------- ----- --------------------------------------------- ----------------------------------------------
------------------- ----- --------------------------------------------- ----------------------------------------------
       EACH         19.
    REPORTING             SOLE DISPOSITIVE POWER                                                              918,482
------------------- ----- --------------------------------------------- ----------------------------------------------
------------------- ----- --------------------------------------------- ----------------------------------------------
   PERSON WITH:     20.
                          SHARED DISPOSTIVE POWER                                                           1,318,148
------------------- ----- --------------------------------------------- ----------------------------------------------
--------- ---------------------------------------------------------------------------- -------------------------------
21.
          AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON                                      2,236,630
--------- ---------------------------------------------------------------------------- -------------------------------
--------- ------------------------------------------------------------------------------------------------------------
22.
          CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS)
--------- ------------------------------------------------------------------------------------------------------------
--------- ---------------------------------------------------------------------------- -------------------------------
23.
          PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)                                                     4.2 %
--------- ---------------------------------------------------------------------------- -------------------------------
--------- ---------------------------------------------------------------------------- -------------------------------
24.
          TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)                                                    IN
--------- ---------------------------------------------------------------------------- -------------------------------









ITEM 1.
        (a) Name of Issuer: Cytori Therapeutics, Inc.
                            3020 Callan Road

        (b) Address of Issuer's Principal Executive Offices: San Diego, CA 92121

Item 2.         (a) Name of Person Filing:


                This Schedule 13G/A is being filed by Gagnon Securities
                LLC and Neil Gagnon (together, the "Reporting
                Persons"). Gagnon Securities LLC is an investment
                adviser registered under Section 203 of the Investment
                Advisers Act of 1940 that furnishes investment advice
                to several customer accounts, foundations,
                partnerships, trusts, and private investment funds
                (collectively, the "Funds"). Mr. Gagnon is the managing
                member and the principal owner of Gagnon Securities
                LLC. In its role as investment manager to the Funds,
                Gagnon Securities LLC shares investment and/or voting
                power with Mr. Gagnon with respect to certain
                securities of the Issuer described in this Schedule
                that are owned by the Funds. Additionally, Mr. Gagnon
                has sole voting power and sole dispositive power with
                respect to certain securities of the Issuer, he shares
                voting power and dispositive power with respect to
                certain other securities of the Issuer with certain
                persons, and he shares dispositive power with certain
                persons over certain other securities of the Issuer but
                has no voting power with respect to such securities.
                The Reporting Persons expressly disclaim beneficial
                ownership of all securities held in the Funds'
                accounts. No single client's interest as reported in
                the customer accounts at Gagnon Securities LLC exceeds
                5% of the outstanding Common Stock of the Issuer. In
                addition, the filing of this Schedule 13G/A shall not
                be construed as an admission that the Reporting Persons
                or any of their affiliates are beneficial owners of any
                securities covered by this Schedule 13G/A for any other
                purposes than Section 13(d) of the Securities Exchange
                Act of 1934.


(b) Address of Principal Business Office or, if none, Residence:
                                           1370 Ave. of the Americas, Suite 2400
                                           New York, NY 10019

                                          GAGNON SECURITIES LLC: Delaware Limited Liability Company
(c) Citizenship:                          NEIL GAGNON: USA

(d) Title of Class of Securities: Common Stock, par value $0.001 per share

(e) CUSIP Number: 23283K105








Item 3. If this statement is filed pursuant to ss.ss.240.13d-1(b) or
            240.13d-2(b) or (c), check whether the person filing is a:
        (a) [ ]  Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o).
        (b) [ ]  Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c).
        (c) [ ]  Insurance company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c).
        (d) [ ]  Investment  company  registered  under section 8 of the Investment  Company Act of 1940 (15 U.S.C
                 80a-8).
        (e) [X] An investment adviser in accordance with ss.240.13d-1(b)(1)(ii)(E);
        (f) [ ] An employee benefit plan or endowment fund in accordance with
        ss.240.13d-1(b)(1)(ii)(F);
        (g) [ ] A parent holding company or control  person in accordance with ss. 240.13d-1(b)(1)(ii)(G);
        (h) [ ] A savings associations as defined in Section 3(b) of the Federal Deposit Insurance
                Act (12 U.S.C. 1813);
        (i) [ ] A church plan that is excluded from the definition of  an investment company under section
                3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3);
        (j) [ ] Group, in accordance with ss.240.13d-1(b)(1)(ii)(J).

            ITEM 4. OWNERSHIP.

          Provide the following information regarding the aggregate number and
percentage of the class of securities of the issuer identified in Item 1.


     (a) Amount beneficially owned:      GAGNON SECURITIES LLC: 1,043,105
                                         NEIL GAGNON: 2,236,630

                                         GAGNON SECURITIES LLC: 2.1%
                                         NEIL GAGNON: 4.2%

     (b) Percent of class:

                         Calculation of percentage of beneficial ownership is
                         based on the sum of (i) 50,509,914 outstanding shares
                         of Issuer's Common Stock as filed with the SEC on
                         November 8, 2010, (ii) 1,428,571 shares sold in a
                         private placement as disclosed on the Issuer's 8-K as
                         filed with the SEC on December 12, 2010 and (iii)
                         698,423 shares of Issuer's Common Stock issuable upon
                         the exercise of warrants issued to the accounts managed
                         by the Reporting Persons.



     (c) Number of shares as to which the person has:

     (i)  Sole power to vote or to direct the vote:     GAGNON SECURITIES LLC:         0
                                                        NEIL GAGNON:             918,482

     (ii) Shared power to vote or to direct the vote:   GAGNON SECURITIES LLC: 1,043,105
                                                        NEIL GAGNON:           1,292,824

     (iii) Sole power to dispose or to direct the      GAGNON SECURITIES LLC:          0
           disposition of:                             NEIL GAGNON:              918,482

     (iv) Shared power to dispose or to direct the    GAGNON SECURITIES LLC:   1,043,105
          disposition of:                             NEIL GAGNON:             1,318,148


ITEM 5           OWNERSHIP OF FIVE PERCENT OR LESS OF A CLASS

Not applicable.

ITEM 6  OWNERSHIP OF MORE THAN FIVE PERCENT ON BEHALF OF ANOTHER PERSON

     The Funds described above in Item the right to receive or the power to
direct the receipt of dividends from, or the proceeds from the sale of,
securities held in their respective accounts. To the knowledge of the Reporting
Person, the interest in any such Fund does not exceed 5% of the class of
securities. The Reporting Person disclaims beneficial ownership of all such
securities.

ITEMS 7 - 9      Not Applicable

ITEM 10          CERTIFICATION
                 The following certification shall be included if the statement
                 is filed pursuant to ss.240.13d-1(b): By signing below I
                 certify that, to the best of my knowledge and belief, the
                 securities referred to above were acquired and are held in the
                 ordinary course of business and were not
(a)              acquired and are not held for the purpose of or with the effect
                 of changing or influencing the control of the issuer of the
                 securities and were not acquired and are not held in connection
                 with or as a participant in any transaction having that purpose
                 or effect. [X]






                                    SIGNATURE

         After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete and
correct.



February 10, 2011
Date

GAGNON SECURITIES LLC

/s/ Neil Gagnon
Signature

Neil Gagnon
Name/Title


February 10, 2011
Date

/s/ Neil Gagnon
Signature

Neil Gagnon
Name/Title



The original statement shall be signed by each person on whose behalf the
statement is filed or his authorized representative. If the statement is signed
on behalf of a person by his authorized representative other than an executive
officer or general partner of the filing person, evidence of the
representative's authority to sign on behalf of such person shall be filed with
the statement, provided, however, that a power of attorney for this purpose
which is already on file with the Commission may be incorporated by reference.
The name and any title of each person who signs the statement shall be typed or
printed beneath his signature.

NOTE: Schedules filed in paper format shall include a signed original and five
copies of the schedule, including all exhibits. SEE ss.240.13d-7 for other
parties for whom copies are to be sent.

ATTENTION:    INTENTIONAL MISSTATEMENTS OR OMISSIONS OF FACT CONSTITUTE FEDERAL CRIMINAL VIOLATIONS (SEE 18 U.S.C. 1001)