UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                  SCHEDULE 13G

                    Under the Securities Exchange Act of 1934
                               (Amendment No. 12)*



                         PROGENICS PHARMACEUTICALS, INC.
--------------------------------------------------------------------------------
                                (Name of Issuer)



                         COMMON STOCK, par value $0.0013
--------------------------------------------------------------------------------
                         (Title of Class of Securities)



                                    743187106
--------------------------------------------------------------------------------
                                 (CUSIP Number)



                                December 31, 2010
--------------------------------------------------------------------------------
             (Date of Event Which Requires Filing of this Statement)


Check the appropriate box to designate the rule pursuant to which this Schedule
is filed:

                  Rule 13d-1(b)
              ---
                  Rule 13d-1(c)
              ---
               X  Rule 13d-1(d)
              ---

* The remainder of this cover page shall be filled out for a reporting person's
initial filing on this form with respect to the subject class of securities, and
for any subsequent amendment containing information which would alter the
disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the Securities Exchange Act of
1934 (the "Act") or otherwise subject to the liabilities of that section of the
Act but shall be subject to all other provisions of the Act (however, see the
Notes).





CUSIP No.   743187106
          -------------------

--------------------------------------------------------------------------------

     1)    Names of Reporting Person

           S.S. or I.R.S. Identification No. of Above Person

                Tudor Investment Corporation
           ---------------------------------------------------------------------
                22-2514825
           ---------------------------------------------------------------------
--------------------------------------------------------------------------------

     2)    Check the Appropriate Box if a Member of a Group (See Instructions)
           (a)
               -----------------------------------------------------------------
           (b)    X
               -----------------------------------------------------------------
--------------------------------------------------------------------------------

     3)    SEC Use Only
                           -----------------------------------------------------
--------------------------------------------------------------------------------

     4)    Citizenship or Place of Organization        Delaware
                                                --------------------------------
--------------------------------------------------------------------------------
                   (5)   Sole Voting Power                    0
                                            ------------------------------------
Number of Shares   -------------------------------------------------------------
Beneficially       (6)   Shared Voting Power          2,107,881
Owned by Each                                 ----------------------------------
Reporting Person   -------------------------------------------------------------
With               (7)   Sole Dispositive Power               0
                                                 -------------------------------
                   -------------------------------------------------------------
                   (8)   Shared Dispositive Power     2,107,881
                                                   -----------------------------
--------------------------------------------------------------------------------
     9)    Aggregate Amount Beneficially Owned by Each Reporting
           Person                                              2,107,881
                                                           ---------------------
--------------------------------------------------------------------------------
    10)    Check if the Aggregate Amount in Row (9) Excludes Certain Shares
           (See Instructions)
                              --------------------------------------------------
--------------------------------------------------------------------------------

    11)    Percent of Class Represented by Amount in Row 9          6.4%
                                                             -------------------
--------------------------------------------------------------------------------

    12)    Type of Reporting Person (See Instructions)                CO
                                                        ------------------------
--------------------------------------------------------------------------------



                                     Page 2



CUSIP No.   743187106
          -------------------

--------------------------------------------------------------------------------

     1)    Names of Reporting Person

           S.S. or I.R.S. Identification No. of Above Person

             Tudor Group Holdings LLC
           ---------------------------------------------------------------------
             13-3862746
           ---------------------------------------------------------------------
--------------------------------------------------------------------------------

     2)    Check the Appropriate Box if a Member of a Group (See Instructions)
           (a)
               -----------------------------------------------------------------
           (b)    X
               -----------------------------------------------------------------
--------------------------------------------------------------------------------

     3)    SEC Use Only
                           -----------------------------------------------------
--------------------------------------------------------------------------------

     4)    Citizenship or Place of Organization        Delaware
                                                --------------------------------
--------------------------------------------------------------------------------
                   (5)   Sole Voting Power                    0
                                            ------------------------------------
Number of Shares   -------------------------------------------------------------
Beneficially       (6)   Shared Voting Power            234,507
Owned by Each                                 ----------------------------------
Reporting Person   -------------------------------------------------------------
With               (7)   Sole Dispositive Power               0
                                                 -------------------------------
                   -------------------------------------------------------------
                   (8)   Shared Dispositive Power       234,507
                                                   -----------------------------
--------------------------------------------------------------------------------
     9)    Aggregate Amount Beneficially Owned by Each Reporting
           Person                                                234,507
                                                           ---------------------
--------------------------------------------------------------------------------
    10)    Check if the Aggregate Amount in Row (9) Excludes Certain Shares
           (See Instructions)
                              --------------------------------------------------
--------------------------------------------------------------------------------

    11)    Percent of Class Represented by Amount in Row 9          0.7%
                                                             -------------------
--------------------------------------------------------------------------------

    12)    Type of Reporting Person (See Instructions)                OO
                                                        ------------------------
--------------------------------------------------------------------------------



                                     Page 3



CUSIP No.   743187106
          -------------------

--------------------------------------------------------------------------------

     1)    Names of Reporting Person

           S.S. or I.R.S. Identification No. of Above Person

             Paul Tudor Jones, II
           ---------------------------------------------------------------------

           ---------------------------------------------------------------------
--------------------------------------------------------------------------------

     2)    Check the Appropriate Box if a Member of a Group (See Instructions)
           (a)
               -----------------------------------------------------------------
           (b)    X
               -----------------------------------------------------------------
--------------------------------------------------------------------------------

     3)    SEC Use Only
                           -----------------------------------------------------
--------------------------------------------------------------------------------

     4)    Citizenship or Place of Organization             USA
                                                --------------------------------
--------------------------------------------------------------------------------
                   (5)   Sole Voting Power              546,125
                                            ------------------------------------
Number of Shares   -------------------------------------------------------------
Beneficially       (6)   Shared Voting Power          2,342,388
Owned by Each                                 ----------------------------------
Reporting Person   -------------------------------------------------------------
With               (7)   Sole Dispositive Power         546,125
                                                 -------------------------------
                   -------------------------------------------------------------
                   (8)   Shared Dispositive Power     2,342,388
                                                   -----------------------------
--------------------------------------------------------------------------------
     9)    Aggregate Amount Beneficially Owned by Each Reporting
           Person                                              2,888,513
                                                           ---------------------
--------------------------------------------------------------------------------
    10)    Check if the Aggregate Amount in Row (9) Excludes Certain Shares
           (See Instructions)
                              --------------------------------------------------
--------------------------------------------------------------------------------

    11)    Percent of Class Represented by Amount in Row 9          8.7%
                                                             -------------------
--------------------------------------------------------------------------------

    12)    Type of Reporting Person (See Instructions)                IN
                                                        ------------------------
--------------------------------------------------------------------------------



                                     Page 4



CUSIP No.   743187106
          -------------------

--------------------------------------------------------------------------------

     1)    Names of Reporting Person

           S.S. or I.R.S. Identification No. of Above Person

                Mark F. Dalton
           ---------------------------------------------------------------------

           ---------------------------------------------------------------------
--------------------------------------------------------------------------------

     2)    Check the Appropriate Box if a Member of a Group (See Instructions)
           (a)
               -----------------------------------------------------------------
           (b)    X
               -----------------------------------------------------------------
--------------------------------------------------------------------------------

     3)    SEC Use Only
                           -----------------------------------------------------
--------------------------------------------------------------------------------

     4)    Citizenship or Place of Organization             USA
                                                --------------------------------
--------------------------------------------------------------------------------
                   (5)   Sole Voting Power              166,000
                                            ------------------------------------
Number of Shares   -------------------------------------------------------------
Beneficially       (6)   Shared Voting Power          2,358,888
Owned by Each                                 ----------------------------------
Reporting Person   -------------------------------------------------------------
With               (7)   Sole Dispositive Power         166,000
                                                 -------------------------------
                   -------------------------------------------------------------
                   (8)   Shared Dispositive Power     2,358,888
                                                   -----------------------------
--------------------------------------------------------------------------------
     9)    Aggregate Amount Beneficially Owned by Each
           Reporting Person                                    2,524,888
                                                           ---------------------
--------------------------------------------------------------------------------
    10)    Check if the Aggregate Amount in Row (9) Excludes Certain Shares
           (See Instructions)
                              --------------------------------------------------
--------------------------------------------------------------------------------

    11)    Percent of Class Represented by Amount in Row 9          7.6%
                                                             -------------------
--------------------------------------------------------------------------------

    12)    Type of Reporting Person (See Instructions)                IN
                                                        ------------------------
--------------------------------------------------------------------------------



                                     Page 5



CUSIP No.   743187106
          -------------------

--------------------------------------------------------------------------------

     1)    Names of Reporting Person

           S.S. or I.R.S. Identification No. of Above Person

             The Tudor BVI Global Portfolio L.P. (f/k/a The Tudor BVI Global
             Portfolio Ltd.)
           ---------------------------------------------------------------------
             98-0223576
           ---------------------------------------------------------------------
--------------------------------------------------------------------------------

     2)    Check the Appropriate Box if a Member of a Group (See Instructions)
           (a)
               -----------------------------------------------------------------
           (b)    X
               -----------------------------------------------------------------
--------------------------------------------------------------------------------

     3)    SEC Use Only
                           -----------------------------------------------------
--------------------------------------------------------------------------------

     4)    Citizenship or Place of Organization      Cayman Islands
                                                --------------------------------
--------------------------------------------------------------------------------
                   (5)   Sole Voting Power                    0
                                            ------------------------------------
Number of Shares   -------------------------------------------------------------
Beneficially       (6)   Shared Voting Power          1,820,068
Owned by Each                                 ----------------------------------
Reporting Person   -------------------------------------------------------------
With               (7)   Sole Dispositive Power               0
                                                 -------------------------------
                   -------------------------------------------------------------
                   (8)   Shared Dispositive Power     1,820,068
                                                   -----------------------------
--------------------------------------------------------------------------------
     9)    Aggregate Amount Beneficially Owned by Each
           Reporting Person                                    1,820,068
                                                           ---------------------
--------------------------------------------------------------------------------
    10)    Check if the Aggregate Amount in Row (9) Excludes Certain Shares
           (See Instructions)
                              --------------------------------------------------
--------------------------------------------------------------------------------

    11)    Percent of Class Represented by Amount in Row 9          5.5%
                                                             -------------------
--------------------------------------------------------------------------------

    12)    Type of Reporting Person (See Instructions)                PN
                                                        ------------------------
--------------------------------------------------------------------------------



                                     Page 6



CUSIP No.   743187106
          -------------------

--------------------------------------------------------------------------------

     1)    Names of Reporting Person

           S.S. or I.R.S. Identification No. of Above Person

             Tudor Proprietary Trading, L.L.C.
           ---------------------------------------------------------------------
             13-3720063
           ---------------------------------------------------------------------
--------------------------------------------------------------------------------

     2)    Check the Appropriate Box if a Member of a Group (See Instructions)
           (a)
               -----------------------------------------------------------------
           (b)    X
               -----------------------------------------------------------------
--------------------------------------------------------------------------------

     3)    SEC Use Only
                           -----------------------------------------------------
--------------------------------------------------------------------------------

     4)    Citizenship or Place of Organization        Delaware
                                                --------------------------------
--------------------------------------------------------------------------------
                   (5)   Sole Voting Power                    0
                                            ------------------------------------
Number of Shares   -------------------------------------------------------------
Beneficially       (6)   Shared Voting Power            219,107
Owned by Each                                 ----------------------------------
Reporting Person   -------------------------------------------------------------
With               (7)   Sole Dispositive Power               0
                                                 -------------------------------
                   -------------------------------------------------------------
                   (8)   Shared Dispositive Power       219,107
                                                   -----------------------------
--------------------------------------------------------------------------------
     9)    Aggregate Amount Beneficially Owned by Each
           Reporting Person                                      219,107
                                                           ---------------------
--------------------------------------------------------------------------------
    10)    Check if the Aggregate Amount in Row (9) Excludes Certain Shares
           (See Instructions)
                              --------------------------------------------------
--------------------------------------------------------------------------------

    11)    Percent of Class Represented by Amount in Row 9          0.7%
                                                             -------------------
--------------------------------------------------------------------------------

    12)    Type of Reporting Person (See Instructions)                OO
                                                        ------------------------
--------------------------------------------------------------------------------



                                     Page 7



CUSIP No.   743187106
          -------------------

--------------------------------------------------------------------------------

     1)    Names of Reporting Person

           S.S. or I.R.S. Identification No. of Above Person

             Tudor Global Trading LLC
           ---------------------------------------------------------------------
             13-3862744
           ---------------------------------------------------------------------
--------------------------------------------------------------------------------

     2)    Check the Appropriate Box if a Member of a Group (See Instructions)
           (a)
               -----------------------------------------------------------------
           (b)    X
               -----------------------------------------------------------------
--------------------------------------------------------------------------------

     3)    SEC Use Only
                           -----------------------------------------------------
--------------------------------------------------------------------------------

     4)    Citizenship or Place of Organization        Delaware
                                                --------------------------------
--------------------------------------------------------------------------------
                   (5)   Sole Voting Power                    0
                                            ------------------------------------
Number of Shares   -------------------------------------------------------------
Beneficially       (6)   Shared Voting Power             15,400
Owned by Each                                 ----------------------------------
Reporting Person   -------------------------------------------------------------
With               (7)   Sole Dispositive Power               0
                                                 -------------------------------
                   -------------------------------------------------------------
                   (8)   Shared Dispositive Power        15,400
                                                   -----------------------------
--------------------------------------------------------------------------------
     9)    Aggregate Amount Beneficially Owned by Each
           Reporting Person                                       15,400
                                                           ---------------------
--------------------------------------------------------------------------------
    10)    Check if the Aggregate Amount in Row (9) Excludes Certain Shares
           (See Instructions)
                              --------------------------------------------------
--------------------------------------------------------------------------------

    11)    Percent of Class Represented by Amount in Row 9         0.05%
                                                             -------------------
--------------------------------------------------------------------------------

    12)    Type of Reporting Person (See Instructions)                OO
                                                        ------------------------
--------------------------------------------------------------------------------


                                     Page 8





Item 1(a). Name of Issuer:

           Progenics Pharmaceuticals, Inc.

Item 1(b). Address of Issuer's Principal Executive Offices:

           777 Old Saw Mill River Road
           Tarrytown, NY 10591

Item 2(a). Name of Person Filing:

           Tudor Investment Corporation ("TIC")
           Tudor Group Holdings LLC ("TGH")
           Paul Tudor Jones, II
           Mark F. Dalton
           The Tudor BVI Global Portfolio L.P. ("Tudor BVI")
           Tudor Proprietary Trading, L.L.C. ("TPT")
           Tudor Global Trading LLC ("TGT")

Item 2(b). Address of Principal Business Office or, if none, Residence:

           The principal business office of each of TIC, TGH, TPT and TGT is:

                       1275 King Street
                       Greenwich, CT 06831

           The principal business office of each of Messrs. Jones and Dalton
           is:

                       c/o Tudor Investment Corporation
                       1275 King Street
                       Greenwich, CT 06831

           The principal business office of Tudor BVI is:

                       c/o CITCO
                       Kaya Flamboyan 9
                       Curacao, Netherlands Antilles

Item 2(c). Citizenship:

           TIC is a Delaware corporation
           Tudor BVI is a limited partnership organized under the laws of
           the Cayman Islands
           Messrs.  Jones and Dalton are citizens of the United States
           TGH, TPT and TGT are Delaware limited liability companies

Item 2(d). Title of Class of Securities:

           Common Stock, par value $0.0013



                                     Page 9






Item 2(e). CUSIP Number:

           743187106

Item 3.    If this statement is filed pursuant to Rules 13d-1(b), or
           13d-2(b), check whether the person filing is a:

     (a)   ___ Broker or dealer registered under section 15 of the Act
               (15 U.S.C. 78o).

     (b)   ___ Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c).

     (c)   ___ Insurance company as defined in section 3(a)(19) of the Act
               (15 U.S.C. 78c).

     (d)   ___ Investment company registered under section 8 of the Investment
               Company Act of 1940 (15 U.S.C. 80a-8).

     (e)   ___ An investment advisor in accordance with
               ss.240.13d-1(b)(1)(ii)(E).

     (f)   ___ An employee benefit plan or endowment fund in accordance with
               ss.240.13d-1(b)(1)(ii)(F).

     (g)   ___ A parent holding company or control person in accordance with
               ss.240.13d-1(b)(1)(ii)(G).

     (h)   ___ A savings association as defined in Section 3(b) of the Federal
               Deposit Insurance Act (12 U.S.C. 1813).

     (i)   ___ A church plan that is excluded from the definition of an
               investment company under Section 3(c)(14) of the Investment
               Company Act of 1940 (15 U.S.C. 80a-3).

     (j)   ___ A non-U.S. institution in accordance with
               ss. 240.13d-1(b)(1)(ii)(J);

     (k)   ___ Group, in accordance with ss. 240.13d-1(b)(1)(ii)(K).

     If filing as a non-U.S. institution in accordance with
ss. 240.13d-1(b)(1)(ii)(J), please specify the type of institution: ____________


Item 4.    Ownership (as of December 31, 2010).

        (a) Amount Beneficially Owned: See Item 9 of cover pages

        (b) Percent of Class: See Item 11 of cover pages

        (c) Number of shares as to which such person has:

           (i)   sole power to vote or to direct the vote
                 See Item 5 of cover pages
                 ---------------------------------------------------------------

           (ii)  shared power to vote or to direct the vote
                 See Item 6 of cover pages
                 ---------------------------------------------------------------

           (iii) sole power to dispose or to direct the  disposition of
                 See Item 7 of cover pages
                 ---------------------------------------------------------------


                                    Page 10





           (iv)  shared power to dispose or to direct the disposition of
                 See Item 8 of cover pages
                 ---------------------------------------------------------------

         The shares of common stock ("Shares") reported herein as beneficially
owned by TIC, TGH, Mr. Jones and/or Mr. Dalton include shares owned directly by
Tudor BVI (1,820,068 Shares), TPT (219,107 Shares), and/or TGT (15,400 Shares).

         Because TIC provides investment advisory services to Tudor BVI, TIC may
be deemed to beneficially own the Shares owned by Tudor BVI. TIC expressly
disclaims beneficial ownership of such Shares. TGH holds a majority of the
equity interests of TGT and indirectly holds a majority of the membership
interests of TPT. TGH expressly disclaims beneficial ownership of the Shares
beneficially owned by each of such entities. Mr. Dalton, as the sole general
partner of D.F. Partners, a New York limited partnership, may be deemed to
beneficially own the Shares owned by such entity (16,500 Shares). Mr. Dalton
expressly disclaims beneficial ownership of such Shares. Mr. Jones is the
Co-Chairman and principal equity owner of TIC and TGH. Mr. Jones expressly
disclaims beneficial ownership of the Shares beneficially owned, or deemed
beneficially owned, by such entities. Mr. Dalton is (i) the Co-Chairman, Chief
Executive Officer, President, and an equity owner of TIC and (ii) the
Co-Chairman, Chief Executive Officer, and an equity owner of TGH. Mr. Dalton
expressly disclaims beneficial ownership of the Shares beneficially owned, or
deemed beneficially owned, by such entities.

         The Shares reported herein under Items 5 and 7 of Mr. Jones' cover page
include 4,600 Shares held directly by Mr. Jones' individual retirement account.

         The Shares reported herein under Items 5 and 7 of Mr. Dalton's cover
page include 87,500 immediately exercisable options (the "Options"). 2,500 of
the Options expired unexercised on January 1, 2011. As of the date of this
filing, Mr. Dalton owns 85,000 of the Options. Further, the Shares reported
herein under Items 5 and 7 of Mr. Dalton's cover page include 78,500 of the
Shares.

Item 5.    Ownership of Five Percent or Less of a Class.

               Not applicable

Item 6.    Ownership of More than Five Percent on Behalf of Another Person.

               Not applicable

Item 7.    Identification  and  Classification  of the Subsidiary Which Acquired
           the Security Being Reported on By the Parents Holding Company.

               Not applicable

Item 8.    Identification and Classification of Members of the Group.

               See cover pages

Item 9.    Notice of Dissolution of Group.

               Not applicable

Item 10.   Certification.


                                    Page 11





               By signing below I certify that, to the best of my knowledge and
belief, the securities referred to above were acquired and are held in the
ordinary course of business and were not acquired and are not held for the
purpose of or with the effect of changing or influencing the control of the
issuer of the securities and were not acquired and are not held in connection
with or as a participant in any transaction having that purpose or effect.












                                    Page 12






               After reasonable inquiry and to the best of my knowledge and
belief, I certify that the information set forth in this statement is true,
complete and correct.


                                          Dated: February 11, 2011

                                          TUDOR INVESTMENT CORPORATION


                                          By:  /s/ Stephen N. Waldman
                                              ----------------------------------
                                              Stephen N. Waldman
                                              Managing Director and Associate
                                                General Counsel

                                          TUDOR GROUP HOLDINGS LLC


                                          By:  /s/ Stephen N. Waldman
                                              ----------------------------------
                                              Stephen N. Waldman
                                              Managing Director and Associate
                                                General Counsel



                                               /s/ Paul Tudor Jones, II
                                          --------------------------------------
                                              Paul Tudor Jones, II



                                               /s/ Mark F. Dalton
                                          --------------------------------------
                                              Mark F. Dalton


                                          THE TUDOR BVI GLOBAL PORTFOLIO L.P.

                                          By:  Tudor BVI GP Ltd.
                                          Its: General Partner

                                          By:  Tudor Investment Corporation,
                                               Trading Advisor

                                          By:  /s/ Stephen N. Waldman
                                              ----------------------------------
                                              Stephen N. Waldman
                                              Managing Director and Associate
                                                General Counsel


                                          TUDOR PROPRIETARY TRADING, L.L.C.









                                          By:  /s/ Stephen N. Waldman
                                              ----------------------------------
                                              Stephen N. Waldman
                                              Managing Director and Associate
                                                General Counsel

                                          TUDOR GLOBAL TRADING LLC


                                          By:  /s/ Stephen N. Waldman
                                              ----------------------------------
                                              Stephen N. Waldman
                                              Managing Director and Associate
                                                General Counsel