The markets closed lower with the Dow falling 33 points to 18,448 ahead of Federal Reserve chair Janet Yellen's speech tomorrow. Nasdaq lost 5 points to 5,212.
On the upside
A federal judge ruled that Roxane Laboratories infringed on two of Vanda Pharmaceuticals' (Nasdaq: VNDA) patents.
Applied Optoelectronics (Nasdaq: AAOI) received initial orders for its 40Gbps QSFP+ and 100Gbps QSFP28 optical transceiver modules from a new hyper-scale datacenter customer.
Shares of generic EpiPen maker Antares Pharma (Nasdaq: ATRS) climbed.
On the downside
Resolute Energy (NYSE: REN) chief executive Nicholas J. Sutton will retire on December 31, 2016.
Investors continued to lock in profits on Amedica (Nasdaq: AMDA).
Amazon's (Nasdaq: AMZN) launch of Amazon Vehicle sent shares of TrueCar (Nasdaq: TRUE) lower.
In the broad market, advancing issues outpaced decliners by a margin of nearly 5 to 4 on both the NYSE and on Nasdaq. The broader S&P 500 slipped 2 points to 2,172. Bitcoin lost $4 to $574.
