Ownership Submission
FORM 4
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
OMB APPROVAL
OMB Number: 3235-0287
Expires: January 31, 2005
Estimated average burden hours per response... 0.5

(Print or Type Responses)
1. Name and Address of Reporting Person *
BAKER JULIAN
  2. Issuer Name and Ticker or Trading Symbol
INCYTE CORP [INCY]
5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
__X__ Director __X__ 10% Owner
_____ Officer (give title below) _____ Other (specify below)
(Last)
(First)
(Middle)
667 MADISON AVENUE, 21ST FLOOR
3. Date of Earliest Transaction (Month/Day/Year)
11/08/2013
(Street)

NEW YORK, NY US 10065
4. If Amendment, Date Original Filed(Month/Day/Year)
6. Individual or Joint/Group Filing(Check Applicable Line)
___ Form filed by One Reporting Person
_X_ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)
2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code
(Instr. 8)
4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)
5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)
6. Ownership Form: Direct (D) or Indirect (I)
(Instr. 4)
7. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V Amount (A) or (D) Price

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB control number. SEC 1474 (9-02)

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 3)
2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code
(Instr. 8)
5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4, and 5)
6. Date Exercisable and Expiration Date
(Month/Day/Year)
7. Title and Amount of Underlying Securities
(Instr. 3 and 4)
8. Price of Derivative Security
(Instr. 5)
9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 4)
10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4)
11. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
0.375% Convertible Senior Note due 2018 $ 51.758 11/08/2013   P   25,000,000 (1)     (2) 11/15/2018 Common Stock 483,017 $ 100 25,000,000 I See Footnote (3) (10)
0.375% Convertible Senior Note due 2018 $ 51.758 11/08/2013   P   219,544,000 (1)     (2) 11/15/2018 Common Stock 4,241,740 $ 100 219,544,000 I See Footnote (4) (10)
0.375% Convertible Senior Note due 2018 $ 51.758 11/08/2013   P   5,456,000 (1)     (2) 11/15/2018 Common Stock 105,414 $ 100 5,456,000 I See Footnote (5) (10)
0.375% Convertible Senior Note due 2018 $ 51.758 11/08/2013   P   3,415,000     (2) 11/15/2018 Common Stock 65,980 $ 104.125 222,959,000 I See Footnote (4) (10)
0.375% Convertible Senior Note due 2018 $ 51.758 11/08/2013   P   85,000     (2) 11/15/2018 Common Stock 1,642 $ 104.125 5,541,000 I See Footnote (5) (10)
0.375% Convertible Senior Note due 2018 $ 51.758 11/08/2013   P   5,367,000     (2) 11/15/2018 Common Stock 103,694 $ 104.0909 228,326,000 I See Footnote (4) (10)
0.375% Convertible Senior Note due 2018 $ 51.758 11/08/2013   P   133,000     (2) 11/15/2018 Common Stock 2,570 $ 104.0909 5,674,000 I See Footnote (5) (10)
1.25% Convertible Senior Note due 2020 $ 51.758 11/08/2013   P   25,000,000 (1)     (2) 11/15/2020 Common Stock 483,017 $ 100 25,000,000 I See Footnote (3) (10)
1.25% Convertible Senior Note due 2020 $ 51.758 11/08/2013   P   219,544,000 (1)     (2) 11/15/2020 Common Stock 4,241,740 $ 100 219,544,000 I See Footnote (4) (10)
1.25% Convertible Senior Note due 2020 $ 51.758 11/08/2013   P   5,456,000 (1)     (2) 11/15/2020 Common Stock 105,414 $ 100 5,456,000 I See Footnote (5) (10)
1.25% Convertible Senior Note due 2020 $ 51.758 11/08/2013   P   4,879,000     (2) 11/15/2020 Common Stock 94,265 $ 104.75 224,423,000 I See Footnote (4) (10)
1.25% Convertible Senior Note due 2020 $ 51.758 11/08/2013   P   121,000     (2) 11/15/2020 Common Stock 2,338 $ 104.75 5,577,000 I See Footnote (5) (10)
1.25% Convertible Senior Note due 2020 $ 51.758 11/08/2013   P   2,439,000     (2) 11/15/2020 Common Stock 47,123 $ 103.75 226,862,000 I See Footnote (4) (10)
1.25% Convertible Senior Note due 2020 $ 51.758 11/08/2013   P   61,000     (2) 11/15/2020 Common Stock 1,179 $ 103.75 5,638,000 I See Footnote (5) (10)
1.25% Convertible Senior Note due 2020 $ 51.758 11/08/2013   P   9,758,000     (2) 11/15/2020 Common Stock 188,531 $ 104.25 236,620,000 I See Footnote (4) (10)
1.25% Convertible Senior Note due 2020 $ 51.758 11/08/2013   P   242,000     (2) 11/15/2020 Common Stock 4,676 $ 104.25 5,880,000 I See Footnote (5) (10)
1.25% Convertible Senior Note due 2020 $ 51.758 11/08/2013   P   6,830,000     (2) 11/15/2020 Common Stock 131,960 $ 104.5179 243,450,000 I See Footnote (4) (10)
1.25% Convertible Senior Note due 2020 $ 51.758 11/08/2013   P   170,000     (2) 11/15/2020 Common Stock 3,285 $ 104.5179 6,050,000 I See Footnote (5) (10)
4.75% Convertible Senior Note due 2015 (6) $ 8.775               (2) 10/01/2015 Common Stock 7,289   64,000 D  
4.75% Convertible Senior Note due 2015 (7) $ 8.775               (2) 10/01/2015 Common Stock 7,403   65,000 D  
4.75% Convertible Senior Note due 2015 $ 8.775 11/08/2013   D     20,922,000 (8)   (2) 10/01/2015 Common Stock 2,384,274 $ 425.8779 8,671,000 I See Footnote (3) (10)
4.75% Convertible Senior Note due 2015 $ 8.775 11/08/2013   D     88,153,000 (8)   (2) 10/01/2015 Common Stock 10,045,926 $ 425.8779 36,534,000 I See Footnote (4) (10)
4.75% Convertible Senior Note due 2015 $ 8.775 11/08/2013   D     2,459,000 (8)   (2) 10/01/2015 Common Stock 280,228 $ 425.8779 1,019,000 I See Footnote (5) (10)
4.75% Convertible Senior Note due 2015 $ 8.775 11/08/2013   D     1,084,000 (9)   (2) 10/01/2015 Common Stock 123,533 $ 432.6015 7,587,000 I See Footnote (3) (10)
4.75% Convertible Senior Note due 2015 $ 8.775 11/08/2013   D     4,567,000 (9)   (2) 10/01/2015 Common Stock 520,456 $ 432.6015 31,967,000 I See Footnote (4) (10)
4.75% Convertible Senior Note due 2015 $ 8.775 11/08/2013   D     127,000 (9)   (2) 10/01/2015 Common Stock 14,473 $ 432.6015 892,000 I See Footnote (5) (10)

Reporting Owners

Reporting Owner Name / Address Relationships
 Director  10% Owner  Officer  Other
BAKER JULIAN
667 MADISON AVENUE, 21ST FLOOR
NEW YORK, NY US 10065
  X   X    
BAKER FELIX
667 MADISON AVENUE, 21ST FLOOR
NEW YORK, NY US 10065
  X   X    
BAKER BROS. ADVISORS LP
667 MADISON AVENUE, 21ST FLOOR
NEW YORK, NY US 10065
  X   X    
667, L.P.
667 MADISON AVENUE 21ST FLOOR
NEW YORK, NY US 10065
  X   X    
Baker Brothers Life Sciences LP
667 MADISON AVENUE, 21ST FLOOR
NEW YORK, NY US 10065
  X   X    
14159, L.P.
667 MADISION AVENUE, 21ST FLOOR
NEW YORK, NY US 10065
  X   X    
Baker Bros. Advisors (GP) LLC
667 MADISION AVENUE 21ST FLOOR
NEW YORK, NY US 10065
  X   X    

Signatures

 /s/ Julian C. Baker   11/13/2013
**Signature of Reporting Person Date

 /s/ Felix J. Baker   11/13/2013
**Signature of Reporting Person Date

 By: Baker Bros. Advisors LP, Name: Scott L. Lessing, Title: President /s/ Scott L. Lessing   11/13/2013
**Signature of Reporting Person Date

 Baker Bros. Advisors LP, Mgmt. Co. and Inv. Adviser to 667, L.P., pursuant to authority granted by Baker Biotech Capital, L.P., GP to 667, L.P. Name: Scott L. Lessing, Title: President /s/ Scott L. Lessing   11/13/2013
**Signature of Reporting Person Date

 Baker Bros. Advisors LP, Mgmt. Co. and Inv. Adviser to BAKER BROTHERS LIFE SCIENCES, L.P., pursuant to authority granted by Baker Brothers Life Sciences Capital, L.P., GP to Baker Brothers Life Sciences, L.P Name:Scott L. Lessing, Title: President /s/   11/13/2013
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) On November 8, 2013 667, L.P. ("667"), Baker Brothers Life Sciences, L.P. ("Life Sciences") and 14159, L.P. ("14159, and together with 667 and Life Sciences, the "Funds") purchased 0.375% Convertible Senior Unsecured Notes due November 15, 2018 and 1.25% Convertible Senior Unsecured Notes due November 14, 2020 issued by Incyte Corporation (the "Issuer") at par value as part of a private placement.
(2) Immediately.
(3) As a result of their ownership interest in Baker Biotech Capital (GP), LLC, Felix J. Baker and Julian C. Baker may be deemed to have an indirect pecuniary interest in securities of the Issuer directly held by 667 a limited partnership of which the sole general partner is Baker Biotech Capital, L.P., a limited partnership of which the sole general partner is Baker Biotech Capital (GP), LLC, due to Baker Biotech Capital, L.P.'s right to receive an allocation of a portion of the profits from 667.
(4) As a result of their ownership interest in Baker Brothers Life Sciences Capital (GP), LLC, Felix J. Baker and Julian C. Baker may be deemed to have an indirect pecuniary interest in securities of the Issuer directly held by Life Sciences, a limited partnership of which the sole general partner is Baker Brothers Life Sciences Capital, L.P., a limited partnership of which the sole general partner is Baker Brothers Life Sciences Capital (GP), LLC, due to Baker Brothers Life Sciences Capital, L.P.'s right to receive an allocation of a portion of the profits from Life Sciences.
(5) As a result of their ownership interest in 14159 Capital (GP), LLC, Felix J. Baker and Julian C. Baker may be deemed to have an indirect pecuniary interest in securities of the Issuer directly held by 14159, a limited partnership of which the sole general partner is 14159 Capital L.P., a limited partnership of which the sole general partner is 14159 Capital (GP), LLC, due to 14159 Capital L.P.'s right to receive an allocation of a portion of the profits from 14159.
(6) Reflects 4.75% Convertible Senior Notes due 2015 of the Issuer held directly by Julian C. Baker.
(7) Reflects 4.75% Convertible Senior Notes due 2015 of the Issuer held directly by Felix J. Baker.
(8) On November 8, 2013 the Issuer pursuant to a repurchase agreement with 667, Life Sciences and 14159 repurchased $20,922,000, $88,153,000, and $2,459,000 principal, respectively, of the Issuer's 4.75% Convertible Senior Notes due 2015.
(9) On November 8, 2013 the Issuer pursuant to an additional repurchase agreement with 667, Life Sciences and 14159 repurchased $1,084,000, $4,567,000, and $127,000 principal, respectively, of the Issuer's 4.75% Convertible Senior Notes due 2015.
(10) Baker Bros. Advisors LP (the "Adviser") serves as the Investment Adviser to the Funds. In connection with the services provided by the Adviser, the Adviser receives an asset-based management fee that does not confer any pecuniary interest in the securities held by the Funds. Baker Bros. Advisors (GP) LLC (the "Adviser GP") is the Adviser's sole general partner. Julian C. Baker and Felix J. Baker are principals of the Adviser GP. The Adviser has complete and unlimited discretion and authority with respect to the investment and voting power of the securities held by the Funds. The general partners of the Funds and the Funds relinquished to the Adviser all discretion and authority with respect to the investment and voting power of the securities held by the Funds. Julian C. Baker, Felix J. Baker, the Adviser GP and the Adviser disclaim beneficial ownership of the securities held directly by the Funds except to the extent of their pecuniary interest therein, and this report shall not be deemed an admission that any of Julian C. Baker, Felix J. Baker, the Adviser GP or the Adviser is a beneficial owner of such securities for purposes of Section 16 or any other purpose.
 
Remarks:
Julian C. Baker is a director of Incyte Corporation (the "Issuer"). By virtue of his representation on the Board of Directors of the Issuer, for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, the reporting persons are deemed directors by deputization of the Issuer.

Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.

Potential persons who are to respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB number.