Benzinga's Top Pre-Market Losers

Rigel Pharmaceuticals (NASDAQ: RIGL ) shares fell 30.96% to $5.82 in the pre-market trading. Rigel Pharmaceuticals' trailing-twelve-month ROE is -45.82%. Endo Health Solutions (NASDAQ: ENDP ) shares dropped 6.38% to $25.84 in pre-market trading. Endo cut its earnings view for 2012 and 2013. Ciena (NASDAQ: CIEN )